Protein Alignment neb and klp-6

DIOPT Version :9

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_498069.1
• Gene: klp-6 / 175683
• WormBaseID: WBGene00002218
• Length: 928
• Species: Caenorhabditis elegans
• Alignment Length: 1131
• Identity: 313/1131 - (27%)
• Similarity: 481/1131 - (42%)
• Gaps: 344/1131 - (30%)

  Fly   120 NMIVAVRVRPLNALECTRG---------QVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQ 175
            ::||||||||.|..|.||.         :.|.|::                |........|:||.
 Worm     6 SIIVAVRVRPFNDREKTRNCKLVIEMPDEETTVIR----------------DPKTNDEKRFTYDH 54

  Fly   176 VYYSCD--PERKN---------FACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMG 229
            .|:|.|  .|:||         :|.|.:|||...|.::..|:.|||..||||||||||||||::|
 Worm    55 SYWSHDGFSEKKNGYLEPTDPHYADQRRVFEDLGRGVLANAWAGYNCSLFAYGQTGSGKSYSIVG 119

  Fly   230 IEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQH 294
            .:             :..||:|..|.|||::| |...::.:|.||.||..|||.||:.||||
 Worm   120 FK-------------NNKGIVPIVCEELFKQI-ADNKKKNMQFEVFVSMMEIYCEKVRDLLS--- 167

  Fly   295 AAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTA 359
                   |||      ..:..|||||||..|.||.:|:...|:|:..:...:..|...|..|:|.
 Worm   168 -------STP------PPKGGLKVREHPKNGFYVENLTTVPVNSFKEIEAKIEEGTKSRTIAATQ 219

  Fly   360 MNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNG 424
            ||..|||:|:|..|..|........|.|             .::|:|:|||||||||.|.:|:.|
 Worm   220 MNATSSRAHTIVKITFNQKSSKQAGGTS-------------MKKSEINLVDLAGSERQSAAGTEG 271

  Fly   425 ERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKT 489
            :|::||:.||:||.|||:||.||.||:||      .|| ..|.:|||:||||.||:..|||||||
 Worm   272 DRLKEGIVINQSLTTLGRVIKALHDSQKA------KSG-KKTQIPYRDSVLTCLLKNALGGNSKT 329

  Fly   490 VMLATISPASIHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQR 554
            :|:|.||||.|:.:|||:|||:|.:|:||.....|||:..::.:|:||.|     :||.:.:.|.
 Worm   330 IMIAAISPADINFEETLSTLRFADRAKSIKTNAVVNENQTERALRELREE-----NLRLQSQIQG 389

  Fly   555 RLSGNSNNPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLK 619
            ..:|:::|              .|:|.||:||||.::|:...:|||.:|:  ||:..|......:
 Worm   390 GTAGDASN--------------EEIEKLRRQLAENQKEMEEMEKSWQQKI--AEEAAKHASGASE 438

  Fly   620 RRGLALELTAEQKQAC-LVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLV 683
            :    :|:.|::|:.| |.||..||.|:..:.:.:|     :|...:....:||...|.:.|..:
 Worm   439 K----VEMEAKKKKMCHLWNLNEDPALTNVIVHFIP-----VGESVVGNKPTSSGNFIQMSGLSI 494

  Fly   684 ALQHCSIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGK 748
            ..||.:::::...::::.|.|||.:.::||:.:....||...||:..||:|.:..:||
 Worm   495 LPQHVTLKNDGNNQIHLSPCSEDLDIFINGKPVHGETQLQQNDRVFFGGNHLYVFNNP------- 552

  Fly   749 ADHPVDFQLAHQEILQKQEQQLRSELEAEKRAALTKIEQERAQHARDFEERLQCLELEQFKYKCN 813
                                        .|:...|.|..|.||           .|:.|
 Worm   553 ----------------------------TKKGIRTDITYENAQ-----------AEIAQ------ 572

  Fly   814 SEMLETERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQRIMLNPSEESLHKTQLMVKEATQ 878
                   ..|.||..:          .:...:::..||           ||.|..|..:|:.|..
 Worm   573 -------NHAAALGNR----------GLGGGSKRDLIL-----------EEELMSTLPLVQRANA 609

  Fly   879 RCRQLDLPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPTARL-GVWLDLVRDNAE------- 935
            ...:|...::|.             ::|:..:.|||     |:.| .:|:. |.:.:|
 Worm   610 MATELGRNVKFE-------------IVLVSPEMRGL-----TSGLTEIWVK-VHNISEDTYFLWE 655

  Fly   936 ----------QQEKLNATTIFQSVEVDW----------EPLDA------------------DLNE 962
                      .||...|.   |....||          ||.|:                  |:.|
 Worm   656 KSRFMNRYYGMQEMYEAK---QDGSEDWNMPKERDPFYEPPDSPVFIASSVVFLQSLAYLIDVEE 717

  Fly   963 TLSDTHNSSR----IALNLSAMK--------------DVLLNKPL-------------KRLLNAS 996
            .......|.:    :.:.||...              |.|:.|.:             :|:|.::
 Worm   718 QFPIVDLSGQEIGLLTVGLSPCSTTGKELRGEYVEDPDQLIGKNIAFKVKVISAVGLPRRILKSN 782

  Fly   997 ------SSKSNTPRQT---STPSPGS----QLVHFTKRLLTY--------------DPEEIPESQ 1034
                  .||..|...|   :||:.|.    |....||.:..|              .|......:
 Worm   783 CKYRFFGSKKMTTTATVSGNTPAYGHEETFQFKPVTKEVADYLANSNLYITFWGTQRPRGASSRK 847

  Fly  1035 SSFTTLVQQELQIMQRSAQRLRRHCEAALLERENHQDNGVLAVSLQEALARMDTVLNGM------ 1093
            :|.:|:...|.:.....|:|:.|     |:.:....:|..::|.      .::|||.|:
 Worm   848 NSISTIGSNEAREGPNKAKRVER-----LVHQAKTSENRNISVK------ALETVLKGVDDNENR 901

  Fly  1094 ---HTSLARAEATACVT-SPTKTQKA 1115
               ..|:.:|.:|...: |.:|..||
 Worm   902 KTRKQSMKKAGSTTIKSRSGSKKPKA 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	171/424 (40%)
		KISc	120..525	CDD:214526	171/424 (40%)
		Kinesin_assoc	524..657	CDD:292801	39/133 (29%)
		FHA	634..740	CDD:238017	28/106 (26%)
klp-6	NP_498069.1	KISc_KIF1A_KIF1B	5..365	CDD:276816	171/424 (40%)
		KISc	6..365	CDD:214526	171/424 (40%)
		FliJ	365..448	CDD:280262	29/107 (27%)
		FHA	449..549	CDD:238017	28/104 (27%)
		KIF1B	659..699	CDD:289208	9/42 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3453
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.730