Protein Alignment neb and unc-104

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_001022041.2
• Gene: unc-104 / 174144
• WormBaseID: WBGene00006831
• Length: 1628
• Species: Caenorhabditis elegans
• Alignment Length: 1187
• Identity: 348/1187 - (29%)
• Similarity: 527/1187 - (44%)
• Gaps: 293/1187 - (24%)

  Fly   119 SNMIVAVRVRPLNALECTRGQVTN----VVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYS 179
            |::.|||||||.|..|     ::|    |:||:||:..:...:.:..:.|      |::|..|:|
 Worm     2 SSVKVAVRVRPFNQRE-----ISNTSKCVLQVNGNTTTINGHSINKENFS------FNFDHSYWS 55

  Fly   180 CDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPH 244
            ......:|..|.:|:|.....:::.||||||.|:||||||||||||:||| :|.|.
 Worm    56 FARNDPHFITQKQVYEELGVEMLEHAFEGYNVCIFAYGQTGSGKSYTMMG-KANDP--------- 110

  Fly   245 DEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQ 309
            ||.|||||.|::||.||:. .:.:.:|..|||||.|||.|::.|||:.....
 Worm   111 DEMGIIPRLCNDLFARIDN-NNDKDVQYSVEVSYMEIYCERVKDLLNPNSGG------------- 161

  Fly   310 QQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIV 374
                 .|:|||||:.||||.||:..:|.||..:.|.:..||..|..|:|.||..|||||::|.||
 Worm   162 -----NLRVREHPLLGPYVDDLTKMAVCSYHDICNLMDEGNKARTVAATNMNSTSSRSHAVFTIV 221

  Fly   375 LNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLT 439
            |......:|..|  ||:          :.|||||||||||||.:.:|:.|:|::||.:|||||.|
 Worm   222 LTQKRHCADSNL--DTE----------KHSKISLVDLAGSERANSTGAEGQRLKEGANINKSLTT 274

  Fly   440 LGKVIAALAD--SRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHA 502
            ||.||:.||:  ::|..:|        ...:|||:|||||||||||||||||.|||.:|||.|:.
 Worm   275 LGLVISKLAEESTKKKKSN--------KGVIPYRDSVLTWLLRENLGGNSKTAMLAALSPADINF 331

  Fly   503 DETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRK 567
            ||||:|||||.:|:.||.:..|||.|:.|:||:|..||.:|:.:..:                 |
 Worm   332 DETLSTLRYADRAKQIVCQAVVNEDPNAKLIRELNEEVIKLRHILKD-----------------K 379

  Fly   568 IIIETSVDET------------EVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKR 620
            .|..|.|.||            .|....::|.|.|:.::...|:|.:||...|:.||.....|:.
 Worm   380 GIDVTDVQETPGKHKKGPKLPAHVHEQLEKLQESEKLMAEIGKTWEQKLIHTEEIRKQREEELRD 444

  Fly   621 RGLA-------LELTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVL 678
            .|||       |.:.:.:|...||||..||::|..|.|.|.:|:..:||     ..:..:|||:|
 Worm   445 MGLACAEDGTTLGVFSPKKLPHLVNLNEDPLMSECLIYYLKEGVTSVGR-----PEAEHRPDILL 504

  Fly   679 DGPLVALQHCSIEHERGG-KLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPF 742
            .|..:...||...:|.|. .|.:.|.:   ..|:||:.:.....|..|.|:::|..|.||.::|.
 Worm   505 SGEAILELHCEFINEDGNVTLTMKPNA---SCYINGKQVTTPTVLHTGSRVILGEHHVFRYNDPQ 566

  Fly   743 CSQRGK------ADHPVDFQLAHQEILQKQEQQLRS-------ELEAEKRAALTKIEQERAQHAR 794
            .:::.:      |:.|:|::.|.||:|.||...|::       |:|::.|....::||:.....|
 Worm   567 EARQSRHNLAAIAEQPIDWKYAQQELLDKQGIDLKADMEKKMLEMESQYRREKVELEQKMYHQTR 631

  Fly   795 DFEERLQCL----ELEQFKYKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDI- 854
            ::|..::.|    :|.|........:.|.||.   |.......|   |:...|..||..:|:..
 Worm   632 EYESMIENLQKQVDLAQSYISGGGSIWEGERM---LTSSLLEFP---EELKWTSDQKRVVLKAAI 690

  Fly   855 --QRIMLNPSEESLHKTQLMVKEATQRCRQLDLPLEFR---QTQT-----------PDEFGLLR- 902
              :........:.|....:.||||.....:|...::|:   .|.|           |.|...||
 Worm   691 KWRYHQFTSVRDDLWGNAIFVKEANAISVELKKKVQFQFALLTDTMYSPLPPDLLPPGEDLTLRP 755

  Fly   903 ---TVILI--LDKQRGLKAEWPTARL------------------GV------------WLDLVRD 932
               ||:.|  .|.:.|....|...:|                  |.            ||..:..
 Worm   756 YPKTVVAIQVQDLKNGATHYWSIEKLKQRLEDMRIFYNSELSVAGTPVDVPYPPVAEGWLAALNR 820

  Fly   933 NAEQ----QEKLNATTIFQSVEVDWEPLDAD-LNETLSDTH------------NSSRIALNLSAM 980
            |:.:    :::|.|.......:.:..|.|.| :.:.|..|.            ..:.:.||
 Worm   821 NSARLIPDRQRLEAMRDMYETDAEMSPADGDPMMDALMGTDPFYDRFPWFRMVGRAFVYLN---- 881

  Fly   981 KDVLLNKPLKRLLNASSSKSNTP----------------------RQTSTPSPGSQLVHFTKR-- 1021
             ::|.|.||...:...:.|....                      |||:.       :||.|.
 Worm   882 -NLLHNVPLIHKVAVVNEKGEVKGYLKVAIEPVQKDEVINQKKGVRQTAK-------LHFRKEDF 938

  Fly  1022 LLTYDPEEIPESQS-SFTTLVQQELQIMQR------------------SAQRLRRHCEAALLERE 1067
            |.::...|..:|.: :|...:|:|::...|                  ....|.||.||...|..
 Worm   939 LKSHKNGETSDSDALAFPEHMQEEVEFCFRVVVLQAIDVADTYSDVFCQFNFLHRHDEAFSTEPM 1003

  Fly  1068 NHQDNGVLAVSLQEALARMD-TVLNGMH---------------------------------TSLA 1098
            .:..:.:.....|....:|. |.|:.:|                                 |.|.
 Worm  1004 KNSKSPLTFEHTQNLHIKMSKTFLHYLHHFPIIFEVFGHFQPKSEQFNFERQNSALGRRLSTKLT 1068

  Fly  1099 RAEATACVTSPTKTQKA 1115
            ..:.:..:::|.|::||
 Worm  1069 FQQPSLVISTPVKSKKA 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	181/411 (44%)
		SMC_N	514..>615	CDD:481474	31/112 (28%)
		FHA_KIF14	627..741	CDD:438759	35/114 (31%)
unc-104	NP_001022041.2	KISc_KIF1A_KIF1B	2..354	CDD:276816	181/411 (44%)
		Kinesin_assoc	351..488	CDD:465047	44/153 (29%)
		FHA_KIF1	464..564	CDD:438757	34/107 (32%)
		Rcc_KIF21	595..652	CDD:425381	13/56 (23%)
		KIF1B	829..875	CDD:463574	7/45 (16%)
		DUF3694	1116..1260	CDD:463599
		PH_KIFIA_KIFIB	1500..1602	CDD:269939