DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and Kif4

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	NP_032472.2	Gene:	Kif4 / 16571	MGIID:	108389	Length:	1231	Species:	Mus musculus

Alignment Length:	1073	Identity:	280/1073 - (26%)
Similarity:	446/1073 - (41%)	Gaps:	267/1073 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSCDPERKNF 187
            ||:|.|||.:.|...|..|.:..|.|   |..|..|:  |.|      |:||.|:   ||..:
Mouse    12 VALRCRPLVSKEIKEGCQTCLSFVPG---EPQVVVGN--DKS------FTYDFVF---DPSTE-- 60

  Fly   188 ACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEA-GIIP 251
              |.:||.....|||...|:||||.:.|||||||||:|||.|       |......||.| |:||
Mouse    61 --QEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGG-------AYTAEQEHDSAIGVIP 116

  Fly   252 RFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPAL 316
            |....||:.|   ..:...:..::|||.|||||:|.|||.                ..:::...:
Mouse   117 RVIQLLFKEI---NKKSDFEFTLKVSYLEIYNEEILDLLC----------------SSREKATQI 162

  Fly   317 KVREHPIFGPYVVDLSAHSV----DSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNL 377
            .:||.|..|..:|.|:..:|    |:.|.|..    ||:.|..||||||.:|||||:||.|
Mouse   163 NIREDPKEGIKIVGLTEKTVLVASDTVSCLEQ----GNNSRTVASTAMNSQSSRSHAIFTI---- 219

  Fly   378 TDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGK 442
               |.:....:|.:||.        |||:.|||||||||...:.:.|:|:|||::||:.||.||.
Mouse   220 ---SIEQRKKNDKNSSF--------RSKLHLVDLAGSERQKKTKAEGDRLREGININRGLLCLGN 273

  Fly   443 VIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLA 507
            ||:||.|.:|            ..|||||:|.||.||:::|||||.|:|:|.:|||..:.:|||.
Mouse   274 VISALGDDKK------------GNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLN 326

  Fly   508 TLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIET 572
            |||||.:||.|.|:..:|..|....:..|:.:|.:|:.|         |.......:|..|.:|.
Mouse   327 TLRYADRARKIKNKPIINIDPQAAELNHLKQQVQQLQIL---------LLQAHGGTLPGDINVEP 382

  Fly   573 SVDETEVEALRQQLAERERELSRA-------QKSWMEKL---KEAEDQRKSELRVLKRRGLALEL 627
            |.:...:....|.|.|...:|||.       ....:|::   ::|.::..::|..|:|..
Mouse   383 SENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRRHA----- 442

  Fly   628 TAEQKQAC------LVNLTADPILSGTLFYL--LPQGLVRIGRGRL--------PGGSSSSQ--- 673
                  ||      ||....|..|...:..:  |.|.:.::.....        ..|.:.:|
Mouse   443 ------ACKVDLQKLVETLEDQELKENIEIICNLQQVIAQLSDEAAACMTATIDTAGEADTQVQS 501

  Fly   674 -PDIVLDGPLVALQHCSIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFR 737
             ||......:.:.||...:.:...:|..:..:...:..:..::.::..||
Mouse   502 SPDTSRSSDVFSTQHALRQAQMSKELIELNKALALKEALAKKMTQNDNQL--------------- 551

  Fly   738 ISNPFCSQRGKADHPVDFQL------AHQEI--LQKQEQQLRSELE-AEKRAALTKIEQERAQHA 793
                         .|:.||.      ...|:  ||:::::|..||: |:|.|...|:.:.|.:..
Mouse   552 -------------QPIQFQYQDNIKNLESEVLSLQREKEELVLELQTAKKDANQAKLSERRRKRL 603

  Fly   794 RDFEERLQCLELEQFKYKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQRIM 858
            ::.|.::..|:          :.|:.:.:.|.|.:..|||             .|.:.::| |:|
Mouse   604 QELEGQIADLK----------KKLQEQSKLLKLKESTEHT-------------VSKLNQEI-RMM 644

  Fly   859 LNPSEESLHKTQLM--VKEATQRCRQLDLP-----LEFRQTQTPDEFGLLRTVILILDKQRGL-- 914
            .|      .:.|||  :||..::.||....     ::.::.....::.||: :.....||..:
Mouse   645 KN------QRVQLMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQYELLK-LERNFQKQSNVLR 702

  Fly   915 -KAEWPTARLGVWLDLVRDNAEQQEKLNATTIFQS-------------------VEVDWEPLDAD 959
             |.|...|......|.::...|..||...|   ||                   |.|..|.....
Mouse   703 RKTEEAAAANKRLKDALQKQKEVAEKRKET---QSRGMESTAARMKNWLGNEIEVMVSTEEAKRH 764

  Fly   960 LNETLSDTHNSSRIALNLSAMKDVLLNKPLKRLLNA---------------SSSKSNTPRQTSTP 1009
            ||..|.:....::....|...::...|.|||.....               |.:|.....:|...
Mouse   765 LNGLLEERKILAQDVAQLKEKRESGENPPLKLRRRTFSYDEIHGQDSGAEDSIAKQIESLETELE 829

  Fly  1010 SPGSQLVHFTKRLLTYDPEEIPESQ-SSFTTLVQQELQI----------------MQRSAQRLRR 1057
            ...:|:....::||..:.|:.|:.: .|..|:::.:..|                ::.|..:.:.
Mouse   830 LRSAQIADLQQKLLDAESEDRPKQRWESIATILEAKCAIKYLVGELVSSKILVSKLESSLNQSKA 894

  Fly  1058 HC---EAALLERENHQDNGVLAVSLQEALARMD 1087
            .|   :..|.|.:||  ...:...|:|.|.:::
Mouse   895 SCIDVQKMLFEEQNH--FAKIETELKEELVKVE 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	162/406 (40%)
		KISc	120..525	CDD:214526	162/406 (40%)
		Kinesin_assoc	524..657	CDD:292801	30/150 (20%)
		FHA	634..740	CDD:238017	17/125 (14%)
Kif4	NP_032472.2	KISc_KIF4	8..338	CDD:276823	160/400 (40%)
		KISc	9..344	CDD:214526	162/406 (40%)
		SbcC	407..995	CDD:223496	101/594 (17%)
		Globular	1001..1231
		Pre-SET	<1070..1120	CDD:282838
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1189..1212
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910