Protein Alignment neb and Kif3c

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_032471.2
• Gene: Kif3c / 16570
• MGIID: 107979
• Length: 796
• Species: Mus musculus
• Alignment Length: 848
• Identity: 228/848 - (26%)
• Similarity: 350/848 - (41%)
• Gaps: 274/848 - (32%)

  Fly   100 SRTKERDSLMESCLSVSEESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADAS 164
            |:||..::|.             |..|.|||:..|...|. ..::.:.....::|::...:|...
Mouse     3 SKTKASEALK-------------VVARCRPLSRKEEAAGH-EQILTMDVKLGQVTLRNPRAAPGE 53

  Fly   165 AGVTHFFSYDQVYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMG 229
            ...|  |::|.||   |...|    ||.:::.|.|||||:..:|:|..:|||||||:||:|:|.|
Mouse    54 LPKT--FTFDAVY---DASSK----QADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQG 109

  Fly   230 --IEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSV 292
              :|.            :..|:||.....:|..|...::||.|   |..||.|||.|:|.||||
Mouse   110 TWVEP------------ELRGVIPNAFEHIFTHISRSQNQQYL---VRASYLEIYQEEIRDLLS- 158

  Fly   293 QHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATAS 357
                             ::....|:::|:|..|.|:.|||:....:...:.:.:.:||..||..|
Mouse   159 -----------------KEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQARAVGS 206

  Fly   358 TAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSER------ 416
            |.||:.|||||:||.|.:..::..||   ..|          ..|..|::|||||||||
Mouse   207 THMNEVSSRSHAIFVITVECSERGSD---GQD----------HIRVGKLNLVDLAGSERQNKAGP 258

  Fly   417 --------------------ISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGS 461
                                .|.|.|:|||.:|...||.||..||.||||||.:|
Mouse   259 NAAGGPATQPTAGGGSGSGSASGSASSGERPKEASKINLSLSALGNVIAALAGNR---------- 313

  Fly   462 GTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNE 526
               ||.:|||:|.||.||:::||||:||:|:||:.|||...||:|:|||:|.:|::|.|:.:|||
Mouse   314 ---STHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNE 375

  Fly   527 SPHDKIIRDLRAEVDRLKS------------LRNEYERQRRLSG--------------------N 559
            .|.|.::|:.:.|:.|||:            .|....|::.:|.                    |
Mouse   376 DPKDTLLREFQEEIARLKAQLEKKGMLGKRPRRKSSRRKKAVSAPAGYPEGSVIEAWVAEEEDDN 440

  Fly   560 SNNPVPRKIIIETSVDETEVEALRQQLAERERELSRAQ--KSWM--EKLKEAEDQRKSELRVLKR 620
            :||..|.:.|:|.::::.....|:.|....|.|.:..|  :|.:  ||.|..|::.|. |..|:|
Mouse   441 NNNHHPPQPILEAALEKNMENYLQDQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKM-LEDLRR 504

  Fly   621 RGLALELTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVAL 685
            ...|.||.|.:.:|.
Mouse   505 EQQATELLAAKYKAM-------------------------------------------------- 519

  Fly   686 QHCSIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKAD 750
                                                   ..:|:|||             |...|
Mouse   520 ---------------------------------------ESKLLIGG-------------RNIMD 532

  Fly   751 HPVD----FQLAHQEILQ--------KQEQQLRSELEAEKRAALTKIEQE---RAQHARDFEERL 800
            |..:    .:|..|||.:        :||..||.|...|.|...:.::||   :.:..:....:|
Mouse   533 HTNEQQKMLELKRQEIAEQKRREREMQQEMLLRDEETMELRGTYSSLQQEVEVKTKKLKKLYAKL 597

  Fly   801 QCLELEQFKYKCNSEMLETERQALALAQQQEHTPLRHE----DAVSTPAQKSTILEDIQRIMLNP 861
            |.::.|   .:...|.....||.|..||.::...|:.:    :....|.:|:.|:   .|:.|:.
Mouse   598 QAVKAE---IQDQHEEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIM---NRLFLDC 656

  Fly   862 SEE 864
            .||
Mouse   657 EEE 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	149/433 (34%)
		SMC_N	514..>615	CDD:481474	33/136 (24%)
		FHA_KIF14	627..741	CDD:438759	7/113 (6%)
Kif3c	NP_032471.2	KISc_KIF3	9..367	CDD:276822	148/439 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	252..292		7/39 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..422		3/24 (13%)
		Smc	<452..>637	CDD:440809	50/290 (17%)
		Globular. /evidence=ECO:0000255	633..793		7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	758..796