Protein Alignment neb and Kif3a

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Alignment Length: 864
• Identity: 249/864 - (28%)
• Similarity: 370/864 - (42%)
• Gaps: 227/864 - (26%)

  Fly   110 ESCLSVSEESNMIVAVRVRPLNALE---CTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFF 171
            |||      .|:.|.||.||||..|   |.| |..:|.::.|.   :||.   ..|:|......|
Mouse    10 ESC------DNVKVVVRCRPLNEREKSMCYR-QAVSVDEMRGT---ITVH---KTDSSNEPPKTF 61

  Fly   172 SYDQVYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDA 236
            ::|.|:   .||.|    |..|:..||||:||:..||||..:|||||||:||:::|.|:.|:...
Mouse    62 TFDTVF---GPESK----QLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGL 119

  Fly   237 ALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGE 301
                      .|:||.....:|..|  .|::...:..|.|||.|||||::.|||.
Mouse   120 ----------RGVIPNSFAHIFGHI--AKAEGDTRFLVRVSYLEIYNEEVRDLLG---------- 162

  Fly   302 STPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSR 366
                  :.|.||  |:|:|.|..|.|:.||||:.|::...:...:.:|:..|:..:|.||:.|||
Mouse   163 ------KDQTQR--LEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSR 219

  Fly   367 SHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGV 431
            ||:||.|.:..::...|..:             ..|..|:.|||||||||.:.:|:.|:|::|..
Mouse   220 SHAIFTITIECSEKGVDGNM-------------HVRMGKLHLVDLAGSERQAKTGATGQRLKEAT 271

  Fly   432 SINKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATIS 496
            .||.||.|||.||:||.|.:             ||.||||.|.||.||:::|||||||:|.|.|.
Mouse   272 KINLSLSTLGNVISALVDGK-------------STHVPYRNSKLTRLLQDSLGGNSKTMMCANIG 323

  Fly   497 PASIHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSN 561
            ||..:.|||::|||||.:|::|.|:.::||.|.|.::|..:.|::.||   .:.|....:||:.
Mouse   324 PADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELK---KKLEEGEEVSGSD- 384

  Fly   562 NPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE 626
                    |..|.::.|           |.||             .||..|.:    ||||.:..
Mouse   385 --------ISGSEEDDE-----------EGEL-------------GEDGEKKK----KRRGSSSS 413

  Fly   627 LTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIE 691
            .:::  ..|       .::...|...||.          ..|.....||     .:|.:| ..|:
Mouse   414 SSSD--STC-------SVIEKPLDEFLPH----------QAGKKKVSPD-----KMVEMQ-AKID 453

  Fly   692 HERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGD---------------RLVIGGSHYFRISNP 741
            .||......:...|:.......||.:..:.|....               ::::||
Mouse   454 EERKALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGG--------- 509

  Fly   742 FCSQRGKADHPVDFQLAHQEILQKQEQQLRSELEAEKRAA--LTKIEQERAQHARDFEERLQCLE 804
                       ||. ||..|..:|..::...|||..:|.|  |.|..:|:.|...|.||:...|:
Mouse   510 -----------VDL-LAKAEEQEKLLEESNMELEERRRRAEQLRKELEEKEQERLDIEEKYTSLQ 562

  Fly   805 LE-QFKYK-----------CNSEMLETERQALALAQQQEH-----------TPLRHEDAVSTPAQ 846
            .| |.|.|           ..|||.:.         ||||           ..|..|..:.....
Mouse   563 EEAQGKTKKLKKVWTMLMAAKSEMADL---------QQEHQREIEGLLENIRQLSRELRLQMLII 618

  Fly   847 KSTILEDIQRIMLN--PSEESLHKTQLMVKEATQRCRQLDLPLEFRQTQTPDEFGL--------- 900
            .:.|.:|.|.::.|  ...|.:.:.||.....|....:...|:..::.:.|.|..|
Mouse   619 DNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKERDPFEVDLSHVYLAYTE 683

  Fly   901 --LRTVILILDKQRGLKAE 917
              ||..::.|::.|..|.:
Mouse   684 ESLRQSLMKLERPRTSKGK 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	155/408 (38%)
		SMC_N	514..>615	CDD:481474	23/100 (23%)
		FHA_KIF14	627..741	CDD:438759	18/128 (14%)
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	153/401 (38%)
		Smc	<450..>614	CDD:440809	41/193 (21%)