Protein Alignment neb and Kif1c

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: XP_036012244.1
• Gene: Kif1c / 16562
• MGIID: 1098260
• Length: 1112
• Species: Mus musculus
• Alignment Length: 1043
• Identity: 324/1043 - (31%)
• Similarity: 472/1043 - (45%)
• Gaps: 273/1043 - (26%)

  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSC----DPE 183
            |||||||.||.| |......||.:.||:..: :....|.||...    |::|..|:|.    ||:
Mouse     8 VAVRVRPFNARE-TSQDAKCVVSMQGNTTSI-INPKQSKDAPKS----FTFDYSYWSHTSVEDPQ 66

  Fly   184 RKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAG 248
               ||.|.:|:......::..||||||.|:|||||||:||||:|||.:       :.|    :.|
Mouse    67 ---FASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQ-------EPG----QQG 117

  Fly   249 IIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQR 313
            |:|:.|.:||.|:. |....||...|||||.|||.|::.|||:                  .:.|
Mouse   118 IVPQLCEDLFSRVN-VNQSAQLSYSVEVSYMEIYCERVRDLLN------------------PKSR 163

  Fly   314 PALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLT 378
            .:|:||||||.||||.|||..:|.||:.:.:.:..||..|..|:|.||:.|||||::|.||  .|
Mouse   164 GSLRVREHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIV--FT 226

  Fly   379 DLSSDD--GLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLG 441
            ..|.|.  ||.|:            :.|||||||||||||...||:.|.|::||.:|||||.|||
Mouse   227 QRSHDQLTGLDSE------------KVSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLG 279

  Fly   442 KVIAALAD--SRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADE 504
            |||:||||  |:|          ..|.|:|||:|||||||:|||||||:|.|:|.:|||.|:.:|
Mouse   280 KVISALADLQSKK----------RKSDFIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYEE 334

  Fly   505 TLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNS--------- 560
            ||:|||||.:.:.|.....:||.|:.::||:|:.||.||:.|.    ..:.||.::
Mouse   335 TLSTLRYADRTKQIRCNAVINEDPNARLIRELQEEVARLRDLL----MAQGLSASALGGLKVEEG 395

  Fly   561 ------------------NNPVPRKIIIETSVD---ETEV--EALRQQLAERERELSRAQKSWME 602
                              ::|.|....:|.|..   |.::  |...::|.|.|:.::...::|.|
Mouse   396 SPGGVLPPASSPPAPASPSSPPPHNGELEPSFSPSAEPQIGPEEAMERLQETEKIIAELNETWEE 460

  Fly   603 KLKEAEDQRKSELRVLKRRGLALE-------LTAEQKQACLVNLTADPILSGTLFYLLPQGLVRI 660
            ||::.|..|.....:|...|:|:.       :.:.:|...||||..||::|..|.|.:..|:.|:
Mouse   461 KLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKDGVTRV 525

  Fly   661 GRGRLPGGSSSSQPDIVLDGPLVALQHC---SIEHERGGKLYVIPGSEDFETYVNGELLKDRRQL 722
            |:         ...||.|.|..:..|||   ||....|..:..:...|..||||||:|:.:...|
Mouse   526 GQ---------VDVDIKLTGQFIREQHCLFRSIPQPDGEVMVTLEPCEGAETYVNGKLVTEPLVL 581

  Fly   723 FHGDRLVIGGSHYFRISNPFCSQ----------RGKADHPVDFQLAHQEILQKQEQQLRSELEAE 777
            ..|:|:|:|.:|.||.::|..::          .|....|||:..|.:|:|::|...::.|:
Mouse   582 KSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEM--- 643

  Fly   778 KRAALTKIEQERAQHARDFEERLQCLELEQFKYKCNSEMLETERQALALAQQQEHTPLRHEDAVS 842
                               |:|||.||.:..|.|..:::| .|:|.|.........|.::.|:.|
Mouse   644 -------------------EKRLQDLENQYRKEKEEADLL-LEQQRLVRDTWGPTEPGQYADSDS 688

  Fly   843 TPAQKSTILEDIQRIMLNPSEESLHKTQLMVKEATQRC------------RQLDLPLEFRQTQTP 895
            .........|:..| :::...|.|..|  .|:...:||            |...:| :.|:.|..
Mouse   689 GEDSDKRSCEESWR-LISSLREQLPPT--TVQNIVKRCGLPSSGKRRAPRRVYQIP-QRRRLQGK 749

  Fly   896 D-------------------EFGL-----------------LRTVILILDKQRGLKAEWPTARLG 924
            |                   |..|                 :|.:.....|..|....|......
Mouse   750 DPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRELCRTYGKPEGPGDAWRAVARD 814

  Fly   925 VWLDLVRD---------------NAEQQEKLNA-----TTIFQSVEVDWEPLDADLNETLSDTHN 969
            || |.|.:               ...:.|.|.|     |.|.|.|::                .|
Mouse   815 VW-DTVGEEEGCGGGGGGSEEGARGAEVEDLRAHIDKLTGILQEVKL----------------QN 862

  Fly   970 SSRIALNLSAMKDVLLNK----PLKRLLNASSSKSNTPRQTSTPSPGSQLVHFTKRLLTYDPEEI 1030
            ||: ...|.|::|.:|..    ||.:.|...:.:|.                    |:|:.|.|.
Mouse   863 SSK-DRELQALRDRMLRMERVIPLTQDLEDDNDESG--------------------LVTWAPPEG 906

  Fly  1031 PES 1033
            ||:
Mouse   907 PEA 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	182/409 (44%)
		SMC_N	514..>615	CDD:481474	29/132 (22%)
		FHA_KIF14	627..741	CDD:438759	39/116 (34%)
Kif1c	XP_036012244.1	KISc_KIF1A_KIF1B	4..355	CDD:276816	182/409 (44%)
		Kinesin_assoc	352..522	CDD:465047	41/173 (24%)
		FHA_KIF1C	498..599	CDD:438780	38/109 (35%)