DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and Kif1b

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	NP_001277924.1	Gene:	Kif1b / 16561	MGIID:	108426	Length:	1816	Species:	Mus musculus

Alignment Length:	927	Identity:	300/927 - (32%)
Similarity:	449/927 - (48%)	Gaps:	197/927 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYS-CDPERKN 186
            |||||||.|:.| |..:...::|:.|||..: :...:..:|...    ||:|..|:| ..||...
Mouse     8 VAVRVRPFNSRE-TSKESKCIIQMQGNSTSI-INPKNPKEAPKS----FSFDYSYWSHTSPEDPC 66

  Fly   187 FACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIP 251
            ||.|.:|:....:.::..||||||.|:|||||||:||||:|||.:           ...:|||||
Mouse    67 FASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQ-----------EESQAGIIP 120

  Fly   252 RFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPAL 316
            :.|.|||.:|.. ...:::...|||||.|||.|::.|||:                  .:.:..|
Mouse   121 QLCEELFEKIND-NCNEEMSYSVEVSYMEIYCERVRDLLN------------------PKNKGNL 166

  Fly   317 KVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLS 381
            :|||||:.||||.|||..:|.||:.:.:.:..||..|..|:|.||:.|||||::|.||.......
Mouse   167 RVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQD 231

  Fly   382 SDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAA 446
            .:..||::            :.|||||||||||||...:|:.|.|::||.:|||||.||||||:|
Mouse   232 PETNLSTE------------KVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISA 284

  Fly   447 LADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRY 511
            ||:.....:.......|  .|:|||:|||||||||||||||:|.|:|.:|||.|:.||||:||||
Mouse   285 LAEVDNCTSKSKKKKKT--DFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRY 347

  Fly   512 ACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSL------------------------------ 546
            |.:|:.|.....:||.|:.|::|:|:.||.|||.|
Mouse   348 ADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGGKYLKDF 412

  Fly   547 ---RNEY----ERQRRLSGN-------SNNPVPRKIIIETSVDETEVEALR-------------Q 584
               ::.|    |.||  .||       |....|....:.:.|..|.|.:::             :
Mouse   413 QNNKHRYLLASENQR--PGNFSTASMGSLTSSPSSCSLNSQVGLTSVTSIQERIMSTPGGEEAIE 475

  Fly   585 QLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLA-------LELTAEQKQACLVNLTAD 642
            :|.|.|:.::...::|.|||::.|..|.....:|...|:|       |.:.:.:|...||||..|
Mouse   476 RLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNED 540

  Fly   643 PILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHER---GGKLYVIPGS 704
            |::|..|.|.:..|:.|:|:     ..:..:.||||.|..:..:||....||   |..:..:...
Mouse   541 PLMSECLLYYIKDGITRVGQ-----ADAERRQDIVLSGAHIKEEHCLFRSERSNTGEVIVTLEPC 600

  Fly   705 EDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKAD-----------HPVDFQLA 758
            |..||||||:.:....||..|:|:::|.:|.||.::|   ::.:|:           .|||:..|
Mouse   601 ERSETYVNGKRVAHPVQLRSGNRIIMGKNHVFRFNHP---EQARAEREKTPSAETPSEPVDWTFA 662

  Fly   759 HQEILQKQEQQLRSELE--AEKRAALTKIEQERA-----QHARDFEERLQCLELEQFKYKCNSEM 816
            .:|:|:||...::.|:|  .::...|.|.|:|.|     |...|:|.:||.|:.:.......:|.
Mouse   663 QRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQRQVETRSLAAET 727

  Fly   817 LETERQALALAQQQEHTP-LRHEDAVST------PAQKSTILEDIQRIMLNPSEESLHKTQLMVK 874
            .|.|       :::|..| .:||..::.      .:.:.|.|.|:           |....:.:|
Mouse   728 TEEE-------EEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDL-----------LWGNAVYLK 774

  Fly   875 EATQRCRQLD----------------------LPLEFRQTQTPDEFGLLRTVIL--ILDKQRGLK 915
            ||.....:|.                      ||.|..:|.....|.  |||:.  :.|.:.|..
Mouse   775 EANAISVELKKKVQFQFVLLTDTLYSPVPPELLPSEMEKTHEDRPFP--RTVVAVEVQDLKNGAT 837

  Fly   916 AEWPTARLGVWLDLVRD 932
            ..|...:|...|||:|:
Mouse   838 HYWSLDKLKQRLDLMRE 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	172/402 (43%)
		KISc	120..525	CDD:214526	172/402 (43%)
		Kinesin_assoc	524..657	CDD:292801	46/196 (23%)
		FHA	634..740	CDD:238017	37/108 (34%)
Kif1b	NP_001277924.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	172/402 (43%)
		KISc	5..361	CDD:214526	172/402 (43%)
		Interaction with KBP. /evidence=ECO:0000250	270..350		50/81 (62%)
		Kinesin_assoc	358..555	CDD:292801	46/198 (23%)
		FHA	532..636	CDD:238017	37/108 (34%)
		Prefoldin	662..717	CDD:298833	18/54 (33%)
		KIF1B	845..892	CDD:289208	5/10 (50%)
		DUF3694	1313..1413	CDD:289256
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1522..1571
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1620..1659
		PH_KIFIA_KIFIB	1701..1799	CDD:269939
		PH	1702..1795	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820