Protein Alignment neb and Kif17

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_034753.1
• Gene: Kif17 / 16559
• MGIID: 1098229
• Length: 1038
• Species: Mus musculus
• Alignment Length: 1094
• Identity: 292/1094 - (26%)
• Similarity: 443/1094 - (40%)
• Gaps: 282/1094 - (25%)

  Fly   123 VAVRVRPLN----ALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSCDPE 183
            |.||.||:|    .|.|     .:||.|.....:..:|...:||..   ...|::|..||.
Mouse     8 VVVRCRPMNKRERELSC-----QSVVTVDSARGQCFIQNPGAADEP---PKQFTFDGAYYI---- 60

  Fly   184 RKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAG 248
             ::|..|  ::...|.||::...||||..:|||||||||||::|.|:.          .|..:.|
Mouse    61 -EHFTEQ--IYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLP----------DPPCQRG 112

  Fly   249 IIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQR 313
            ||||....:|   |:|:..:..:..|..||.|||||.:||||         |..|       :||
Mouse   113 IIPRAFEHVF---ESVQCAENTKFLVRASYLEIYNEDVHDLL---------GADT-------KQR 158

  Fly   314 PALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIF--NIVLN 376
              |:::|||..|.||..||.|:|.:.:.....:..|...||...|.||..||||||||  ||.:.
Mouse   159 --LELKEHPEKGVYVKGLSMHTVHNVAQCERVMETGWKNRAVGYTLMNKDSSRSHSIFTINIEIY 221

  Fly   377 LTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLG 441
            ..|....|.|               |..|::|||||||||.|.:|:.|||::|...||.||..||
Mouse   222 AVDERGKDHL---------------RAGKLNLVDLAGSERQSKTGATGERLKEATKINLSLSALG 271

  Fly   442 KVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETL 506
            .||:||.|.|             ...:|||:|.||.||:::||||:||:|:|.:|||..:.||||
Mouse   272 NVISALVDGR-------------CKHIPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETL 323

  Fly   507 ATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVP------ 565
            :|||||.:|::|.|:.::||.|.|.::|:.:.|:.|||::..:......||...:...|
Mouse   324 STLRYANRAKNIKNKPRINEDPKDALLREYQEEIKRLKAILAQQMGPGNLSALLSTQTPPGPVQS 388

  Fly   566 -RKIIIETSVDETEVEALRQQLAER-ERELSRAQKSWMEKLKEAEDQRKSELR---VLKRRGLAL 625
             .|::..|:|.: :.||.:|.:.|. |..|:|.:..:     |||.:.:..|:   ...|....:
Mouse   389 EEKLLSPTTVQQ-DTEAEKQLIREEYEERLARLKADY-----EAEQESRVRLQEDITAMRNSYDV 447

  Fly   626 ELTAEQKQACLVNLTADPILSGTLFYLLPQGLVR---IGRGRLPGGSSSSQPDIVLDGPLVALQH 687
            :|:..|:     ||..:   ..|...|..:.|.:   :.|..|..|...|.|          ||
Mouse   448 KLSTLQE-----NLRKE---KETEAILKAEVLCKTEVMSRAELASGPEYSPP----------LQ- 493

  Fly   688 CSIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRG---KA 749
                               :||.|...:|                      |.|.....|   |:
Mouse   494 -------------------YETAVKPTIL----------------------SMPDMPPSGKVTKS 517

  Fly   750 DHPVDFQLAHQEILQKQ-----------EQQLRSE----------LEAEKRAALTKIEQERAQHA 793
            ..|:.|:..|.|..:.:           |....||          :|....||||:......::.
Mouse   518 QAPLAFEEPHGETSRSEFSFESNECSTLEDSATSEAFPGPEEFSNMEFSMAAALTESRYLPEEYL 582

  Fly   794 RDFEERLQCLELEQFKYKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQRIM 858
            ...|.....||.|::..: |...||..|   .||..|:  |....:|.......:..:.|
Mouse   583 GGQEAAASPLEAERYVQE-NEPSLEPLR---ILASLQD--PFAEVEAKLARLSSTVAMSD----- 636

  Fly   859 LNPSEESLHKTQLMVKEATQRCRQLDLPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPT--- 920
                     .:|.:|.:..::....|| ||...|::..:..:...|:|..:....|:.....
Mouse   637 ---------SSQTVVPQIPKQPSSADL-LEPSDTKSEADVAVADNVVLGTEPDVNLRVAEEVVSE 691

  Fly   921 ARLGVWLD---LVRDNAEQQEKLNATTIFQSVEVDWEPLDAD---LNETLSDTHNSSRIALNLSA 979
            |..|||::   .|...|:..|:.....:...|.|..|.:..:   |.|......:..::...|..
Mouse   692 AETGVWMESEAQVAHVAQVSEEAQPQPLLAMVSVRRESVGVEVAVLTEEELQPVDQQQVLARLQL 756

  Fly   980 MKDVLL------NKPL-------KRLLNASSSKSNTPRQTSTPSPG------------------S 1013
            ::..::      ||.|       ||..:....:.....|.|....|                  |
Mouse   757 LEQQVVGGEQAKNKDLREKHKRRKRYADERKKQLVAALQNSDEDGGDWVLLNVYDSIQEEVRAKS 821

  Fly  1014 QLVHFTKRLLTYDPEEIPESQSSF--------TTLVQQE------LQIMQRSAQRLRRHCEAALL 1064
            :|:...:|.|.....||.:.||.|        .|:.:||      .|::::....:||.|..:.|
Mouse   822 KLLEKMQRKLRAAEVEIKDLQSEFQLEKIDYLATIRRQERDSMLFQQLLEQVQPLIRRDCNYSNL 886

  Fly  1065 E---REN--HQDNGVLAVSLQEALARMDTVLNGMHTSLARAEATACVTSPTKTQ 1113
            |   ||:  .:|||...:.        |.::  :.|||.        ..||.||
Mouse   887 EKIRRESSWDEDNGFWKIP--------DPII--LKTSLP--------VVPTGTQ 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	155/407 (38%)
		SMC_N	514..>615	CDD:481474	28/108 (26%)
		FHA_KIF14	627..741	CDD:438759	19/116 (16%)
Kif17	NP_034753.1	Motor_domain	4..335	CDD:473979	153/400 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..401		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..559		12/77 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..657		6/35 (17%)
		COG4913	655..>874	CDD:443941	40/218 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	916..940		4/7 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	976..1038