Protein Alignment neb and Kif16b

DIOPT Version :9

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: XP_036014693.1
• Gene: Kif16b / 16558
• MGIID: 1098240
• Length: 1908
• Species: Mus musculus
• Alignment Length: 1116
• Identity: 328/1116 - (29%)
• Similarity: 525/1116 - (47%)
• Gaps: 211/1116 - (18%)

  Fly    86 PGRAKTPGTG-----------KSSC--SRTKERDSLMESCLSV--SEESNMIVAVRVRPLNALEC 135
            |....|.|:|           |:.|  ..|.|.:..:|...:|  |.|.::    ..:.:..:|.
Mouse     4 PANVSTSGSGLVGLGAACWVWKALCVFLCTTELEKWVEILAAVLFSGEKDL----EAKFIIQMEK 64

  Fly   136 TRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSCDPERKNFACQAKVFEGTARP 200
            ::..:||          |.:..|.:.|:....|..|:||..:||.|.:..::..|..||:.....
Mouse    65 SKTTITN----------LKIPEGGTGDSGRERTKTFTYDFSFYSADTKSPDYVSQEMVFKTLGTD 119

  Fly   201 LIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVK 265
            ::.:||||||||:||||||||||||:|||         :.|    ::|:|||.|..||.||....
Mouse   120 VVKSAFEGYNACVFAYGQTGSGKSYTMMG---------NSG----DSGLIPRICEALFSRINETT 171

  Fly   266 SQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVD 330
            ...:.....||||.|||||::.|||                :::..:...|:|||||..||||.|
Mouse   172 RWDEASFRTEVSYLEIYNERVRDLL----------------RRKSSKTFNLRVREHPKEGPYVED 220

  Fly   331 LSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTA 395
            ||.|.|.:||.:...:..||..|.||:|.|||.|||||:||.|  ..|....|..:..:|
Mouse   221 LSKHLVQNYSDVEELMDAGNINRTTAATGMNDVSSRSHAIFTI--KFTQAKFDAEMPCET----- 278

  Fly   396 SSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANGPLG 460
                   .|||.|||||||||...:|:.|.|::||.:|||||:|||.||:||||..:..|| ||.
Mouse   279 -------VSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAAN-PLV 335

  Fly   461 SGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVN 525
            . ....|||||:|||||||:::|||||||:|:||||||.::..|||:|||||.:|::|:|:..:|
Mouse   336 K-KKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTIN 399

  Fly   526 ESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSVDETEVEALRQQLAERE 590
            |..:.|:||:||||:.|||:|..:        ||       :|.:   :|.....::.::|.:.|
Mouse   400 EDANVKLIRELRAEIARLKTLLAQ--------GN-------QIAL---LDSPTALSMEEKLHQNE 446

  Fly   591 RELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAEQKQACLVNLTADPILSGTLFYLLPQ 655
            ..:....|.|..|..|.::..|.:...|::.|:.:.|.:|...  |:.:..|.:.:|.:.|.|.:
Mouse   447 ARVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSELPH--LIGIDDDLLSTGIILYHLKE 509

  Fly   656 GLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVIP--GSEDFETYVNGELLKD 718
            |...:||     ..:|::.||||.|..:..:||..|: .||.:.:||  ||   :..|||..:.|
Mouse   510 GQTYVGR-----EDASTEQDIVLHGLDLESEHCVFEN-AGGTVTLIPLRGS---QCSVNGVQIVD 565

  Fly   719 RRQLFHGDRLVIGGSHYFRISNP----FCSQRGKADHPVDFQLAHQEILQKQEQQ---------- 769
            ..||..|..:::|.::.||.::|    ...::.|:.....|.|:..::.:..|..
Mouse   566 ATQLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSCENLSAVMLYNPGL 630

  Fly   770 --------LRSELEAEKRAALTKIEQERAQHARDFEERLQC--LELEQFKYKCNSEMLETE---- 820
                    ||.|.|.::|..|.|:|.:| :...:.||:.:.  .|||:.:.:..:...|||
Mouse   631 FPIKGPICLRLEFERQQREELEKLESKR-KLIEEMEEKQKSDKAELERMQQEVETRRKETEIVQR 694

  Fly   821 --------------------RQALALAQQQEHTPLRHEDAVSTPAQKS-----TILEDIQRIMLN 860
                                :..||..::.|...||.:..:....::.     .|.|:::::...
Mouse   695 QIRKQEESLKRRSFHIENKLKDLLAEKERFEEERLREQQGLEQQRRQEEESLFRIREELRKLQEL 759

  Fly   861 PSEESLHKTQLMVK----EATQRCRQLDLPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPTA 921
            .|.|...|.|:..:    ...|..:...|.||.|:.:..::..:.|  :..|::|  |:....||
Mouse   760 NSHEQAEKVQIFQELDRLHQEQNAQSAKLRLEKRRLEEEEKEQVQR--VAHLEEQ--LRKRQDTA 820

  Fly   922 RLGVWLDLVRDNAE--QQEKLNATTIFQSVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKDVL 984
            .|     |....|:  |:||....:|.::: :..:.:.|..:.|..|         .|...:...
Mouse   821 PL-----LCPGEAQRAQEEKRELESIREAL-LQAKEMRAGGDHTCRD---------ELERAQQYF 870

  Fly   985 LNKPLKRLLNASSSKSNTPRQTSTPSPGSQ-----LVHF-------TKRLLTYD------PEEIP 1031
            |....::|:..:|.:.:..:|....|...|     |.|.       ...|.|.|      |.::.
Mouse   871 LEFKRRQLVKLASLEKDLVQQKDLLSKEVQEEKVALEHVKCDAGGDPSFLATDDGNILGGPPDLD 935

  Fly  1032 ESQSSFTTLVQQELQIMQRSAQRLRRHCEAALLERE---NHQDNGVLAVSLQEALARMDTVLNGM 1093
            :.:::.|.|..:|.|:.    ..|:.|..|.|.|::   :..|:|||  .|...|.:::..:...
Mouse   936 KIKTAETRLQSREHQLQ----DLLQNHLPALLEEKQRVLDALDSGVL--GLDTTLCQVEKEVGEK 994

  Fly  1094 HTSLARAEATA 1104
            ...:|:.:|.|
Mouse   995 EEQIAQYQANA 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	170/405 (42%)
		KISc	120..525	CDD:214526	170/404 (42%)
		Kinesin_assoc	524..657	CDD:292801	33/132 (25%)
		FHA	634..740	CDD:238017	33/107 (31%)
Kif16b	XP_036014693.1	KISc_KIF1A_KIF1B	51..399	CDD:276816	171/406 (42%)
		Kinesin_assoc	398..510	CDD:406567	33/131 (25%)
		FHA	512..577	CDD:395400	24/73 (33%)
		SbcC	<644..1081	CDD:223496	77/388 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820