Protein Alignment neb and KIF18B

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: XP_011522687.1
• Gene: KIF18B / 146909
• HGNCID: 27102
• Length: 873
• Species: Homo sapiens
• Alignment Length: 1061
• Identity: 274/1061 - (25%)
• Similarity: 406/1061 - (38%)
• Gaps: 299/1061 - (28%)

  Fly   117 EESNMIVAVRVRP--LNALECTRGQVTNVVQ---VHGNSNELTVQAGSSADASAGVTH------- 169
            |:|.:.|.|||||  ...|:..|..|..||.   :..|..|   ..|.......|.||
Human    13 EDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEE---PDGGFPGLKWGGTHDGPKKKG 74

  Fly   170 ---FFSYDQVYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIE 231
               .|.:|:|:...       |.|..||:.|...::|:..:|||..:||||.||:||:::|:|.|
Human    75 KDLTFVFDRVFGEA-------ATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGRE 132

  Fly   232 ALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAA 296
                     |.|    ||:.....||:||:||  .||:...||.:||.|:|||:|||||
Human   133 ---------GDP----GIMYLTTVELYRRLEA--RQQEKHFEVLISYQEVYNEQIHDLL------ 176

  Fly   297 AATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMN 361
                          :.:..|.:||.|..|..|..||.|...|...|...|..||..|....|..|
Human   177 --------------EPKGPLAIREDPDKGVVVQGLSFHQPASAEQLLEILTRGNRNRTQHPTDAN 227

  Fly   362 DKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGER 426
            ..|||||:||.|.:...|  ...||:           :..:.:|:||:|||||||.|.:.:.|||
Human   228 ATSSRSHAIFQIFVKQQD--RVPGLT-----------QAVQVAKMSLIDLAGSERASSTHAKGER 279

  Fly   427 IREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVM 491
            :|||.:||:|||.|..|:.||||::..           .|.||||:|.||.||:::||||.:|||
Human   280 LREGANINRSLLALINVLNALADAKGR-----------KTHVPYRDSKLTRLLKDSLGGNCRTVM 333

  Fly   492 LATISPASIHADETLATLRYACKARSIVNRVKVNE-------SPHDKIIRDLRAEVDRLKSLRNE 549
            :|.|||:|:..::|..||:||.:|:.|...:|.|.       |.:..|.:.|:|||..|:.....
Human   334 IAAISPSSLTYEDTYNTLKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQV 398

  Fly   550 YE-----RQRRLSGN----------SNNPVPRKIIIETSVDETEV--EALRQQLAERERELSRAQ 597
            ||     ..:.|.|:          .::|:|.....:....|...  .||:::....|.::.||.
Human   399 YEGGGQPPPQDLPGSPKSGPPPEHLPSSPLPPHPPSQPCTPELPAGPRALQEESLGMEAQVERAM 463

  Fly   598 K---SWMEKLKEAEDQRKSE---------------------------------LRVL---KRRGL 623
            :   |..|:..|.||:..:|                                 .|.|   :.:.|
Human   464 EGNSSDQEQSPEDEDEGPAEEVPTQMPEQNPTHALPESPRLTLQPKPVVGHFSARELDGDRSKQL 528

  Fly   624 ALE-LTAEQKQACLVN----LTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLV 683
            ||: |...|:|..|:.    ||.|.|   |.|..|.| ||:  ..::..|:.:.:...:..|..:
Human   529 ALKVLCVAQRQYSLLQAANLLTPDMI---TEFETLQQ-LVQ--EEKIEPGAEALRTSGLARGAPL 587

  Fly   684 ALQHCS--------IEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRI-S 739
            |.:.||        :..|..|  |..|.:......::|.|                  |...| .
Human   588 AQELCSESIPVPSPLCPEPPG--YTGPVTRTMARRLSGPL------------------HTLGIPP 632

  Fly   740 NPFCSQRGKADHPVDFQLAHQEILQKQEQQLRSELEAEKRAALTKIEQERAQHARDFEERLQCLE 804
            .|.|:....:..|::           ::::..|.|||:...|      .:....|..:..|.||
Human   633 GPNCTPAQGSRWPME-----------KKRRRPSALEADSPMA------PKRGTKRQRQSFLPCL- 679

  Fly   805 LEQFKYKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQK-----STILEDIQRIMLNPSEE 864
                           .|.:|...|..:.......:..|:|...     :|:::  .|:.|.||
Human   680 ---------------RRGSLPDTQPSQGPSTPKGERASSPCHSPRVCPATVIK--SRVPLGPS-- 725

  Fly   865 SLHKTQLMVKEATQRCRQLDLPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPTARLGVWLDL 929
                       |.|.|            .||          |.|          ||..|....||
Human   726 -----------AMQNC------------STP----------LAL----------PTRDLNATFDL 747

  Fly   930 VRDNAEQQEKLNATTIFQSVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKDVLLNKPLKRLLN 994
                   .|:..:...|... :.|:.:..:|:..  |.....|..:.|..||.   .||...|..
Human   748 -------SEEPPSKPSFHEC-IGWDKIPQELSRL--DQPFIPRAPVPLFTMKG---PKPTSSLPG 799

  Fly   995 ASSSKSNTPRQTSTPSPGSQLVHFTKRLLTYDPEEIPES--QSSFTTLVQQELQIMQRSAQRLRR 1057
            .|:.|......:|.....|::.            .:|.|  :.....||..||.:........|.
Human   800 TSACKKKRVASSSVSHGRSRIA------------RLPSSTLKRPAGPLVLPELPLSPLCPSNRRN 852

  Fly  1058 HCEAALLERENHQDNGVLAVS 1078
            ..:...:.|.....|||..||
Human   853 GKDLIRVGRALSAGNGVTKVS 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	152/420 (36%)
		SMC_N	514..>615	CDD:481474	29/160 (18%)
		FHA_KIF14	627..741	CDD:438759	27/126 (21%)
KIF18B	XP_011522687.1	KISc_KIP3_like	16..360	CDD:276821	149/412 (36%)
		PHA03247	<606..851	CDD:223021	63/369 (17%)