Protein Alignment neb and Klp31E

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: XP_061516566.1
• Gene: Klp31E / 1278143
• VectorBaseID: AGAMI1_013230
• Length: 1675
• Species: Anopheles gambiae
• Alignment Length: 1096
• Identity: 277/1096 - (25%)
• Similarity: 437/1096 - (39%)
• Gaps: 293/1096 - (26%)

  Fly   117 EESNMIVAVRVRPLNALE-------CTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYD 174
            :||::.||||:||....|       ||  |||        ..|..|..||.        ..|::|
Mosquito     6 KESSVRVAVRIRPQIPRELIDMCRVCT--QVT--------PGEPQVLLGSD--------KAFTFD 52

  Fly   175 QVYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSM-MGIEALDDAAL 238
            .|:       .....|..|:......|:|.|.:||||.:.|||||||||:|:| .|.|    .||
Mosquito    53 YVF-------DMSTTQVSVYNNCIEKLVDGALQGYNATVLAYGQTGSGKTYTMGTGFE----RAL 106

  Fly   239 DGGPPHDEAGIIPRFCHELFRRIEAVKSQQQ------------LQVEVEVSYFEIYNEKIHDLLS 291
                |..:.|||||....||   |.:...||            :...|...:.|:|||::.|||.
Mosquito   107 ----PEAQEGIIPRAVRHLF---EGIAQLQQNPYDEDGTYLGTVTFSVAAQFMELYNEEVIDLLD 164

  Fly   292 VQHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATA 356
            ..:..|.                ..|:.|....|..|...:...:.......|.|..|...|.||
Mosquito   165 PYNKGAR----------------VFKIFEDATGGISVAGATIKPLAGPQEALNCLQQGALARTTA 213

  Fly   357 STAMNDKSSRSHSIFNIVLNLTDLSSDD---GLSSDTDSSTASSLRQTRRSKISLVDLAGSERIS 418
            ||.||::|||||::|.|::....:.:.:   ....||::.|         ||...||||||||:.
Mosquito   214 STQMNEQSSRSHALFTILIRRQRVMTAEQCGNAEGDTETLT---------SKFHFVDLAGSERLK 269

  Fly   419 VSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENL 483
            .:|:.|||.|||:|||..||.||.||:||.|..|.:::           ||||:|.||.||:::|
Mosquito   270 RTGATGERAREGISINCGLLALGNVISALGDKTKKVSH-----------VPYRDSKLTRLLQDSL 323

  Fly   484 GGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRN 548
            ||||:|:|:|.:||:.....|||.||:||.:||:|.|:|::|:....:.|..||.|:..|:....
Mosquito   324 GGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVQINQDQSSRTISLLRREIANLQLEIL 388

  Fly   549 EYERQRRLSGNSNNPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKL-----KEAE 608
            ||::.:           |.|..:.::..::|....:.|::..:.|.:..|:..|.:     |.|.
Mosquito   389 EYKQGK-----------RSIDADGNIAISDVSLENEMLSQDNKRLQQRVKAMQETINALTEKNAA 442

  Fly   609 DQRKSELRVLKRRGLALELTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQ 673
            .|.:..:..|.:...|.:..|:   |...|..:.|:  ||                 .||:.|:.
Mosquito   443 LQAQQTIASLHKASAAGDGGAD---ATSTNNGSSPV--GT-----------------AGGNDSAM 485

  Fly   674 PDIVLD--GPLVALQHCSIEHER---------------GGKLYVIPGSEDF-ETYVN---GELLK 717
            .::::.  ..:..|:...||.|:               |.|.|  |..||. ||.:|   .|:.|
Mosquito   486 QELIVGYISEIEKLKAKLIESEQMFQQFKKAKSSQSKLGIKTY--PFIEDNPETMINMLKHEMEK 548

  Fly   718 DRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPVDFQLAHQEILQKQEQQLRSELEAEKRAAL 782
            :|..|.  .|.:.|                         |.|:.....|.....|:.|::.:|.:
Mosquito   549 ERETLM--SRSLPG-------------------------LEHESSSMDQNSDSDSDTESDDKAEV 586

  Fly   783 TKIEQERAQHARDFEERLQCLELEQFKYKCNSEMLETERQALALAQQQ--EHTPLRHEDAVSTPA 845
            .:.|.....  .|.|.:::.:           |.||..:|.|.:.:||  :...|..|...:|..
Mosquito   587 LRAEMSDVN--SDIELKVRLI-----------EQLEESQQRLQIMRQQYEKQFNLMKEKISNTER 638

  Fly   846 QKSTILEDIQR----IMLNPSEESLHKTQL-MVKEATQR-CRQLDLPLEFRQTQTPDEFGLLRTV 904
            ::..:|..|..    .|.|..:.|.::|.: .|||..:| ..:|...|...|....:...|.|.:
Mosquito   639 ERDEVLATIGNGGTGAMNNKGQNSGNETAIKRVKEDYERKLNELRRQLNHFQATNKEHLRLQRNM 703

  Fly   905 ------ILILDKQRGLKAEWPTARLGVWLDLVRDNAEQQEKLNATTIFQSVEVDWEPLDADLNET 963
                  |..|   ||..||....:..:...:..::...:|..:..|             .::.:.
Mosquito   704 QAQDAKIKTL---RGELAELKQVKTRLMKKIQEESNRHKEMESRKT-------------REIAQL 752

  Fly   964 LSDTHNSSRIALNLSAM---KDVLLNKPLKRLLNASSSKSN------TPRQTSTPSPGSQLVHFT 1019
            ..:|.....:..:|.|.   ||.:|.:..:.:.|...|:..      ..|.....|.||.| ..|
Mosquito   753 RKETRKHKNMIKSLQAQGAAKDQVLKRKTEEVFNLRKSQRGIMSLKAAGRVQGNTSIGSML-QGT 816

  Fly  1020 KRLLTYDPEEIPESQSSFTTLVQQELQIMQRSAQRLRRHCEAAL-----LE-------------- 1065
            ||.                   :...:.:|||..|..|..:|.|     ||
Mosquito   817 KRF-------------------KSRWEELQRSIMRAARTRQAVLELEMELERVMQERDVLSRDLT 862

  Fly  1066 --RENHQDNGVLAVSLQEALARMDTV---LNGMHTSLARAEATACVTSPTKTQKAV 1116
              |:..:||.  ..:||:.::..||:   :|.:|.::            |:.||::
Mosquito   863 NLRQRRKDNA--ESTLQDLVSEEDTIIANMNYLHDTI------------TELQKSI 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	149/428 (35%)
		SMC_N	514..>615	CDD:481474	23/105 (22%)
		FHA_KIF14	627..741	CDD:438759	28/134 (21%)
Klp31E	XP_061516566.1	None