Protein Alignment neb and unc-104

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: XP_061509099.1
• Gene: unc-104 / 1275256
• VectorBaseID: AGAMI1_003598
• Length: 1863
• Species: Anopheles gambiae
• Alignment Length: 1130
• Identity: 342/1130 - (30%)
• Similarity: 504/1130 - (44%)
• Gaps: 319/1130 - (28%)

  Fly   119 SNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELT---VQAGSSADASAGVTHFFSYDQVYYSC 180
            |::.|||||||.|:.|..| :...::::.||:..:|   |..|||.....     |:||..|:|.
Mosquito     2 SSVKVAVRVRPFNSREIAR-ESKCIIEMAGNTTCITNPKVPPGSSESVKR-----FNYDYSYWSH 60

  Fly   181 DPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHD 245
            ||....|:.||.|:......::..:|:|||.|:|||||||:||||:|||.:.      ||
Mosquito    61 DPRDLEFSTQAMVYSDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGKQE------DG----- 114

  Fly   246 EAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQ 310
            :.|:||..|.:|||||:..:| ..|:..|||||.|||.|::.|||:                  .
Mosquito   115 QEGVIPMICKDLFRRIQETES-DDLKYSVEVSYMEIYCERVRDLLN------------------P 160

  Fly   311 QQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVL 375
            :.:..|||||||:.||||.|||..:|.||..:.:.:..||..|..|:|.||:.|||||::|.|.
Mosquito   161 KNKGNLKVREHPLLGPYVEDLSKLAVTSYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIF- 224

  Fly   376 NLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTL 440
             .|....|          ..:||...:.|||||||||||||...:|:.|.|::||.:|||||.||
Mosquito   225 -FTQKRQD----------RMTSLETEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTL 278

  Fly   441 GKVIAALAD-------SRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPA 498
            ||||:|||:       |:||            .|:|||:|||||||||||||||||.|:|.||||
Mosquito   279 GKVISALAEIASKNKKSKKA------------DFIPYRDSVLTWLLRENLGGNSKTAMIAAISPA 331

  Fly   499 SIHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSL----------------- 546
            .|:.||||:|||||.:|:.||.:..|||..:.|:||:|:.|:.:|:.|
Mosquito   332 DINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRELLKAEGIEVQEGPDGKVV 396

  Fly   547 -----RNEYE-------------------------------RQRRLSGNSNNPVPRKIIIETSVD 575
                 .|:.|                               |.|:.:|:|.         |.:||
Mosquito   397 CEKRYANKDECLIKSDKIESVGGVVITEEGEDGEKKIHSPNRNRKRTGSST---------EMAVD 452

  Fly   576 ETEVEALRQQLAERERELSRAQKSWMEKLKEAED---QRK---SELRV-LKRRGLALELTAEQKQ 633
                     ||...|:.::...::|.||||..|.   ||:   :|:.| :|..|:.:.:.:.:|.
Mosquito   453 ---------QLQASEKLIAELNETWEEKLKRTEQIRVQREAVFAEMGVAVKEDGITVGVFSPKKS 508

  Fly   634 ACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQP-DIVLDGPLVALQHCSIEHERGGK 697
            ..||||..||.||..|.|.:..||.|:|.      |.::.| ||.|.|..:..:||..|: :.|.
Mosquito   509 PHLVNLNEDPTLSECLLYYIKDGLTRLGT------SEANVPQDIQLSGSHILKEHCVFEN-KDGV 566

  Fly   698 LYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNP--------------FCSQRGK 748
            :.::| .:|...||||..:.:...|..|.|:::|.:|.||.::|              .|...|.
Mosquito   567 VTLVP-HKDALVYVNGRKVIEPEVLQTGSRVILGRNHVFRFTHPEQAREKREKNKEVDVCETPGN 630

  Fly   749 ADHPVDFQLAHQEILQKQEQQLRSELE-----------AEKRAALTKIEQERAQHARDFEERLQC 802
            :....|:..|..|:|:||...|::|:|           .|||||..:.|::|    :.:|.|:..
Mosquito   631 SGEIADWNFAQCELLEKQGIDLKAEMEKRLLALEEQYKREKRAADQEFEEQR----KTYEARIDA 691

  Fly   803 LELEQFKYKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQR---IMLNPSEE 864
            |:            .:.|.|::.::....::|                 ||..:   |.:||..|
Mosquito   692 LQ------------KQVEEQSMTMSMYSSYSP-----------------EDFHQEEDIFVNPLFE 727

  Fly   865 S----------------------------LHKTQLMVKEATQRCRQLDLPLEFRQT--------- 892
            |                            |....:.:|||.....:|...::|:.|
Mosquito   728 SCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSP 792

  Fly   893 ----QTP-------------DEFG---LLRTVIL--ILDKQRGLKAEWPTARLGVWLDLVRD--N 933
                .||             ||||   :.||.:.  :.|.:.|....|...:|...|:|:|.  |
Mosquito   793 LPPELTPAPAVGALTNGGQEDEFGQNPIPRTTVAVEVTDTKNGATHYWSLEKLRYRLELMRQIYN 857

  Fly   934 AEQQEKLNATTIFQSVEVDWEP----------LDADLNETLSDTHNSSRIALNLSAMKDV--LLN 986
            .........:.:.:....:..|          ..|:...|......::::...|::..||  .|.
Mosquito   858 TSDTSPELMSFVLELSSGEHSPEYPGIQYQAYARAEHQTTEQPNREAAQLLTGLASNCDVSNCLT 922

  Fly   987 KPLKRLLNASSSKSNTPRQTSTPSPGSQLVHFTKRLLTYDPEEIPESQSSFT--------TLV-- 1041
            .|...:.:.:||.|.:....|.|||.|         :.|| ..|..|.:|.|        ||.
Mosquito   923 SPTTSVSSTASSPSGSCGTASPPSPPS---------VIYD-GSIAGSLNSGTLGKAGTRLTLANL 977

  Fly  1042 ---QQELQIMQRSAQRLRRHCEAAL 1063
               :|.|::|     |...|.||.|
Mosquito   978 MPSRQRLELM-----REMYHNEAEL 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	183/415 (44%)
		SMC_N	514..>615	CDD:481474	33/159 (21%)
		FHA_KIF14	627..741	CDD:438759	38/114 (33%)
unc-104	XP_061509099.1	None