Protein Alignment neb and Kif1c

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_665884.2
• Gene: Kif1c / 113886
• RGDID: 70928
• Length: 1100
• Species: Rattus norvegicus
• Alignment Length: 1053
• Identity: 333/1053 - (31%)
• Similarity: 489/1053 - (46%)
• Gaps: 240/1053 - (22%)

  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSC----DPE 183
            |||||||.||.| |......||.:.||:..: :....|.||...    |::|..|:|.    ||:
  Rat     8 VAVRVRPFNARE-TSQDAKCVVSMQGNTTSI-INPKQSKDAPKS----FTFDYSYWSHTSVEDPQ 66

  Fly   184 RKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAG 248
               ||.|.:|:......::..||||||.|:|||||||:||||:|||.:       :.|    :.|
  Rat    67 ---FASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQ-------EPG----QQG 117

  Fly   249 IIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQR 313
            |:|:.|.:||.|:. |....||...|||||.|||.|::.|||:                  .:.|
  Rat   118 IVPQLCEDLFSRVN-VNQSAQLSYSVEVSYMEIYCERVRDLLN------------------PKSR 163

  Fly   314 PALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLT 378
            .:|:||||||.||||.|||..:|.||:.:.:.:..||..|..|:|.||:.|||||::|.||  .|
  Rat   164 GSLRVREHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIV--FT 226

  Fly   379 DLSSDD--GLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLG 441
            ..|.|.  ||.|:            :.|||||||||||||...||:.|.|::||.:|||||.|||
  Rat   227 QRSHDQLTGLDSE------------KVSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLG 279

  Fly   442 KVIAALAD--SRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADE 504
            |||:||||  |:|          ..|.|:|||:|||||||:|||||||:|.|:|.:|||.|:.:|
  Rat   280 KVISALADLQSKK----------RKSDFIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYEE 334

  Fly   505 TLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNS--------- 560
            ||:|||||.:.:.|.....:||.|:.::||:|:.||.||:.|.    ..:.||.::
  Rat   335 TLSTLRYADRTKQIRCNAVINEDPNARLIRELQEEVARLRELL----MAQGLSASALGGLKVEEG 395

  Fly   561 ------------------NNPVPRKIIIETSVD---ETEV--EALRQQLAERERELSRAQKSWME 602
                              ::|.|....:|.|..   |.::  |...::|.|.|:.::...::|.|
  Rat   396 SPGGVLPAASSPPAPASPSSPPPHNGELEPSFSPSAEPQIGPEEAMERLQETEKIIAELNETWEE 460

  Fly   603 KLKEAEDQRKSELRVLKRRGLALE-------LTAEQKQACLVNLTADPILSGTLFYLLPQGLVRI 660
            ||::.|..|.....:|...|:|:.       :.:.:|...||||..||::|..|.|.:..|:.|:
  Rat   461 KLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKDGVTRV 525

  Fly   661 GRGRLPGGSSSSQPDIVLDGPLVALQHC---SIEHERGGKLYVIPGSEDFETYVNGELLKDRRQL 722
            |:         ...||.|.|..:..|||   ||....|..:..:...|..||||||:|:.:...|
  Rat   526 GQ---------VDVDIKLTGQFIREQHCLFRSIPQPDGEVMVTLEPCEGAETYVNGKLVTEPLVL 581

  Fly   723 FHGDRLVIGGSHYFRISNPFCSQ----------RGKADHPVDFQLAHQEILQKQEQQLRSELEAE 777
            ..|:|:|:|.:|.||.::|..::          .|....|||:..|.:|:|::|...::  ||.|
  Rat   582 KSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIK--LEME 644

  Fly   778 KRAALTKIEQERAQHARDFEERLQCLELEQFKYKCNSEMLE------TERQALALAQQQEHTPLR 836
            ||  |..:|.   |:.::.||  ..|.|||.:...:|:..|      .|.....::..:|..|
  Rat   645 KR--LQDLEN---QYRKEKEE--ADLLLEQQRLYADSDSGEDSDKRSCEESWRLISSLREQLP-- 700

  Fly   837 HEDAVSTPAQKSTILEDI-----------QRIMLNPSEESLH--------KTQLMVKEATQRCRQ 882
                   |....||::..           :|:...|....|.        ...|.::...:.|.:
  Rat   701 -------PNTVQTIVKRCGLPSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYE 758

  Fly   883 LDLPLEFRQTQTPDEFGL----LRTVILILDKQRGLKAEWPTARLGVWLDLVRD----------- 932
            :.| .:||..:...| .|    :|.:.....|..|....|......|| |.|.:
  Rat   759 VAL-ADFRHGRAEIE-ALAALKMRELCRTYGKPEGPGDAWRAVARDVW-DTVGEEEGCGGGGGGG 820

  Fly   933 ----NAEQQEKLNA-----TTIFQSVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKDVLLNK- 987
                ...:.|.|.|     |.|.|.|::                .|||: ...|.|::|.:|..
  Rat   821 EEGARGAEVEDLRAHIDKLTGILQEVKL----------------QNSSK-DRELQALRDRMLRME 868

  Fly   988 ---PLKRLLNASSSKSNTPRQTSTPSPGSQLVHFTKRLLTYD------PEEIPESQSSFTTLVQQ 1043
               ||.:.|...:.:|..  .|..|..||:.|   :..::.|      |...|:|.....:.:.:
  Rat   869 RVIPLTQDLEDDNEESGL--VTWAPPEGSEAV---EEAVSNDHSPAVRPSSPPQSSWERVSRLME 928

  Fly  1044 ELQIMQRSAQRLR 1056
            |....:|.  |||
  Rat   929 EDPAFRRG--RLR 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	182/409 (44%)
		SMC_N	514..>615	CDD:481474	29/132 (22%)
		FHA_KIF14	627..741	CDD:438759	39/116 (34%)
Kif1c	NP_665884.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	182/409 (44%)
		Kinesin_assoc	352..522	CDD:465047	41/173 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..435		5/36 (14%)
		FHA_KIF1C	498..599	CDD:438780	38/109 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	900..924		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	949..1100