DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment neb and KIF3A

DIOPT Version :9

Sequence 1:NP_476817.1 Gene:neb / 35293 FlyBaseID:FBgn0004374 Length:1121 Species:Drosophila melanogaster
Sequence 2:NP_001287720.1 Gene:KIF3A / 11127 HGNCID:6319 Length:726 Species:Homo sapiens


Alignment Length:835 Identity:231/835 - (27%)
Similarity:366/835 - (43%) Gaps:219/835 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 ESCLSVSEESNMIVAVRVRPLNALE---CTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFF 171
            |||      .|:.|.||.||||..|   |.: |..:|.::.|.   :||.   ..|:|......|
Human    10 ESC------DNVKVVVRCRPLNEREKSMCYK-QAVSVDEMRGT---ITVH---KTDSSNEPPKTF 61

  Fly   172 SYDQVYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDA 236
            ::|.|:   .||.|    |..|:..||||:||:..||||..:|||||||:||:::|.|:.|:.:.
Human    62 TFDTVF---GPESK----QLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPEL 119

  Fly   237 ALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGE 301
                      .||||.....:|..|  .|::...:..|.|||.|||||::.|||.          
Human   120 ----------RGIIPNSFAHIFGHI--AKAEGDTRFLVRVSYLEIYNEEVRDLLG---------- 162

  Fly   302 STPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSR 366
                  :.|.||  |:|:|.|..|.|:.||||:.|::...:...:.:|:..|:..:|.||:.|||
Human   163 ------KDQTQR--LEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSR 219

  Fly   367 SHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGV 431
            ||:||.|.:..::...|..:             ..|..|:.|||||||||.:.:|:.|:|::|..
Human   220 SHAIFTITIECSEKGIDGNM-------------HVRMGKLHLVDLAGSERQAKTGATGQRLKEAT 271

  Fly   432 SINKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATIS 496
            .||.||.|||.||:||.|.:             ||.||||.|.||.||:::|||||||:|.|.|.
Human   272 KINLSLSTLGNVISALVDGK-------------STHVPYRNSKLTRLLQDSLGGNSKTMMCANIG 323

  Fly   497 PASIHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSN 561
            ||..:.|||::|||||.:|::|.|:.::||.|.|.::|..:.|::.||   .:.|....:||:  
Human   324 PADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELK---KKLEEGEEISGS-- 383

  Fly   562 NPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE 626
                                          ::|.:::...|:.:..||..|.:    ||||.:..
Human   384 ------------------------------DISGSEEDDDEEGEVGEDGEKRK----KRRGSSSS 414

  Fly   627 LTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIE 691
            .:::  ..|       .::...|...||.          ..|.....||.:::      ....|:
Human   415 SSSD--STC-------SVIEKPLDKFLPN----------QAGKKKVSPDKMIE------MQAKID 454

  Fly   692 HERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGD---------------RLVIGGSHYFRISNP 741
            .||......:...|:.......||.|..:.|....               ::::||......:  
Human   455 EERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKA-- 517

  Fly   742 FCSQRGKADHPVDFQLAHQEILQKQEQQLRSELEAEKRAAL------TKIEQE------------ 788
              .::.|.....:.:|   |..:|:.:|||.|||.:::..|      |.:::|            
Human   518 --EEQEKLLEESNMEL---EERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVW 577

  Fly   789 -------------RAQHARDFEE------------RLQCLELEQFKYKCNSEMLET--------- 819
                         :.:|.|:.|.            |||.|.::.|..:...||:|.         
Human   578 TMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPRDYQEMIENYVHWNEDIG 642

  Fly   820 ERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQRIMLNPSEESLHKTQLMVK 874
            |.|...:|....:  :|.:..|....:|.....|:..:.|..:||||.::.:.::
Human   643 EWQLKCVAYTGNN--MRKQTPVPDKKEKDPFEVDLSHVYLAYTEESLRQSLMKLE 695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nebNP_476817.1 KISc_KIF1A_KIF1B 119..525 CDD:276816 155/408 (38%)
KISc 120..525 CDD:214526 155/407 (38%)
Kinesin_assoc 524..657 CDD:292801 24/132 (18%)
FHA 634..740 CDD:238017 17/120 (14%)
KIF3ANP_001287720.1 KISc_KIF3 13..345 CDD:276822 153/401 (38%)
SMC_prok_B <450..>616 CDD:274008 28/172 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.