Protein Alignment neb and KIF1C

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_006603.2
• Gene: KIF1C / 10749
• HGNCID: 6317
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 1072
• Identity: 331/1072 - (30%)
• Similarity: 488/1072 - (45%)
• Gaps: 252/1072 - (23%)

  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYS-CDPERKN 186
            |||||||.||.| |......||.:.||:..: :....|.||...    |::|..|:| ...|...
Human     8 VAVRVRPFNARE-TSQDAKCVVSMQGNTTSI-INPKQSKDAPKS----FTFDYSYWSHTSTEDPQ 66

  Fly   187 FACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIP 251
            ||.|.:|:......::..||||||.|:|||||||:||||:|||.:       :.|    :.||:|
Human    67 FASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQ-------EPG----QQGIVP 120

  Fly   252 RFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPAL 316
            :.|.:||.|:...:| .||...|||||.|||.|::.|||:                  .:.|.:|
Human   121 QLCEDLFSRVSENQS-AQLSYSVEVSYMEIYCERVRDLLN------------------PKSRGSL 166

  Fly   317 KVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVL------ 375
            :||||||.||||.|||..:|.||:.:.:.:..||..|..|:|.||:.|||||::|.||.
Human   167 RVREHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHD 231

  Fly   376 NLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTL 440
            .||.|.|:                  :.|||||||||||||...||:.|.|::||.:|||||.||
Human   232 QLTGLDSE------------------KVSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTL 278

  Fly   441 GKVIAALAD--SRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHAD 503
            ||||:||||  |:|          ..|.|:|||:|||||||:|||||||:|.|:|.:|||.|:.:
Human   279 GKVISALADMQSKK----------RKSDFIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYE 333

  Fly   504 ETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSL---------------RNEYERQ 553
            |||:|||||.:.:.|.....:||.|:.::||:|:.||.||:.|               ..|...:
Human   334 ETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLMAQGLSASALEGLKTEEGSVR 398

  Fly   554 RRLSGNSNNPVPRKIIIETSVD-----------ETEV--EALRQQLAERERELSRAQKSWMEKLK 605
            ..|...|:.|.|......|:.:           |:::  |...::|.|.|:.::...::|.|||:
Human   399 GALPAVSSPPAPVSPSSPTTHNGELEPSFSPNTESQIGPEEAMERLQETEKIIAELNETWEEKLR 463

  Fly   606 EAEDQRKSELRVLKRRGLALE-------LTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRG 663
            :.|..|.....:|...|:|:.       :.:.:|...||||..||::|..|.|.:..|:.|:|:.
Human   464 KTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKDGVTRVGQV 528

  Fly   664 RLPGGSSSSQPDIVLDGPLVALQHC---SIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHG 725
            .:         ||.|.|..:..|||   ||....|..:..:...|..||||||:|:.:...|..|
Human   529 DM---------DIKLTGQFIREQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGKLVTEPLVLKSG 584

  Fly   726 DRLVIGGSHYFRISNPFCSQ----------RGKADHPVDFQLAHQEILQKQEQQLRSELEAEKRA 780
            :|:|:|.:|.||.::|..::          .|....|||:..|.:|:|::|...::  ||.|||
Human   585 NRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIK--LEMEKR- 646

  Fly   781 ALTKIEQERAQHARDFEERLQCLELEQFKYKC----NSEMLETERQALALAQQQEHTPLRHEDAV 841
             |..:|.   |:.::.||....||.::.....    :|:....|.....::..:|..|
Human   647 -LQDLEN---QYRKEKEEADLLLEQQRLYADSDSGDDSDKRSCEESWRLISSLREQLP------- 700

  Fly   842 STPAQKSTILEDI-----------QRIMLNPSEESLH--------KTQLMVKEATQRCRQLDLPL 887
              |....||::..           :|:...|....|.        ...|.::...:.|.::.| .
Human   701 --PTTVQTIVKRCGLPSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVAL-A 762

  Fly   888 EFRQTQTPDEFGL----LRTVILILDKQRGLKAEWPTARLGVWLDLVRD---------------- 932
            :||..:...| .|    :|.:.....|..|....|......|| |.|.:
Human   763 DFRHGRAEIE-ALAALKMRELCRTYGKPDGPGDAWRAVARDVW-DTVGEEEGGGAGSGGGSEEGA 825

  Fly   933 NAEQQEKLNA-----TTIFQSVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKDVLLNKPLKRL 992
            ...:.|.|.|     |.|.|.|::                .|||: ...|.|::|.:|.  ::|:
Human   826 RGAEVEDLRAHIDKLTGILQEVKL----------------QNSSK-DRELQALRDRMLR--MERV 871

  Fly   993 L------------------------NASSSKSNTPRQTST--PSPGSQLVHFTKRLLTYDPEEIP 1031
            :                        .|:...:.:.|..|.  |||.........||:    ||.|
Human   872 IPLAQDHEDENEEGGEVPWAPPEGSEAAEEAAPSDRMPSARPPSPPLSSWERVSRLM----EEDP 932

  Fly  1032 ESQSSFTTLVQQE---LQIMQRSAQR---LRR 1057
            ..:......::||   ||.:|.|..|   |||
Human   933 AFRRGRLRWLKQEQLRLQGLQGSGGRGGGLRR 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	179/410 (44%)
		SMC_N	514..>615	CDD:481474	29/128 (23%)
		FHA_KIF14	627..741	CDD:438759	39/116 (34%)
KIF1C	NP_006603.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	179/410 (44%)
		Kinesin_assoc	352..522	CDD:465047	41/169 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..438		6/37 (16%)
		FHA_KIF1C	498..599	CDD:438780	38/109 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	808..828		0/19 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	874..924		6/49 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	950..1103		7/15 (47%)