DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and CENPE

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	NP_001804.2	Gene:	CENPE / 1062	HGNCID:	1856	Length:	2701	Species:	Homo sapiens

Alignment Length:	1225	Identity:	293/1225 - (23%)
Similarity:	496/1225 - (40%)	Gaps:	394/1225 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 VSEESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYS 179
            ::||..:.|.|||||||:.|.:.|:...|.....|:....|....|          |::|:|::.
Human     1 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKS----------FNFDRVFHG 55

  Fly   180 CDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPH 244
             :...||      |:|..|.|:||:|.:|||..:||||||.|||:|:|||.|
Human    56 -NETTKN------VYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSE------------- 100

  Fly   245 DEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQ 309
            |..|:|||..|::|::|:....::.|   :.|||.|||||.|.|||.                ..
Human   101 DHLGVIPRAIHDIFQKIKKFPDREFL---LRVSYMEIYNETITDLLC----------------GT 146

  Fly   310 QQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIV 374
            |:.:| |.:||......||.||:...|.:......|:..|...|....|.||.:|||||:||.::
Human   147 QKMKP-LIIREDVNRNVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMI 210

  Fly   375 LNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLT 439
            |.    |.:.|..|:.:.|       .:.|.::|||||||||.:.:|:.|.|::||.:||:||..
Human   211 LE----SREKGEPSNCEGS-------VKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFI 264

  Fly   440 LGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADE 504
            ||:||..|:|       |.:|.     |:.||:|.||.:|:.:||||:||.::.||:|.|.  ||
Human   265 LGQVIKKLSD-------GQVGG-----FINYRDSKLTRILQNSLGGNAKTRIICTITPVSF--DE 315

  Fly   505 TLATLRYACKARSIVNRVKVNESPHD--------KIIRDLR------------------------ 537
            ||..|::|..|:.:.|...|||...|        |.|.||:
Human   316 TLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLL 380

  Fly   538 AEVDRLKSLRNE----------------------YERQRRLS---------GNSNNP----VPRK 567
            .|.|.|:.::||                      .:|:||::         .|||..    :|..
Human   381 EEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTN 445

  Fly   568 IIIET---------SVDE----------------TEVE------ALRQQLAERE----------- 590
            |..:|         .:||                :|:|      .|.|:..|.|
Human   446 ITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNL 510

  Fly   591 ---RELSRAQKSWME-KLKEAEDQRKSELRVLKRRGLALELTAEQKQACLVNLTADPILSGTLFY 651
               .|..|.:|..|| ||||..|  ..|...|:|:      |.:.::..|::
Human   511 VLDYEQLRTEKEEMELKLKEKND--LDEFEALERK------TKKDQEMQLIH------------- 554

  Fly   652 LLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSI-----EHERGGKLYVIPGSED----F 707
                             ..|:..::|        :|..:     |:|...|:.::...||    .
Human   555 -----------------EISNLKNLV--------KHAEVYNQDLENELSSKVELLREKEDQIKKL 594

  Fly   708 ETYVNGELLKD------------------RRQLFHGDRLVIGG---SHYFRISNPFCSQRGK--- 748
            :.|::.:.|::                  ::.||..:.:.:..   |.:.|..|....::.|
Human   595 QEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELA 659

  Fly   749 ---ADHPVDFQLAHQEILQKQEQQLRSELEAEKRAALTKIEQERAQHARDFEERLQC-LELE--- 806
               .....|.||...::..|::.|:  :||.|.::|..:|.:..:.......:.|.| ||||
Human   660 TTYKQMENDIQLYQSQLEAKKKMQV--DLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKI 722

  Fly   807 -QFKYKCNSEMLETE--RQALALAQQQEHTP-----LRHE------------------------- 838
             ..:.:.|.|:.|.|  |:.:.|..:.:..|     ||.|
Human   723 TDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHK 787

  Fly   839 ----------------DAVSTPAQ-KST--------------------ILEDIQRI---MLNPSE 863
                            |..:|.:. |||                    :||:.:|:   ::|.|:
Human   788 ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSK 852

  Fly   864 ESLH--------KTQLMVK-----EATQRCRQLDLPLEFRQTQTPDEFGLLRTVILILDKQRGLK 915
            |:..        ||:|..|     |.|:..::....:|..:.|..:....|:||    ::::.|.
Human   853 EAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTV----EREKTLI 913

  Fly   916 AEWPTARLGVWLDLVRDNAEQQEKLNATTIFQSVEVDWEPLDADLNETLS---DTHNSSRIALNL 977
            .|    :|...|:.|:  ...|||.:...:.:|::::.:.|.:|:::|::   ||....|.||..
Human   914 TE----KLQQTLEEVK--TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES 972

  Fly   978 SAMKDVLLNKPLKRLLNASSSKSNTPRQTSTPSPGSQLVHFTKRLLTYDPEEIPESQSSFT---- 1038
            .......:| .||..::...|: |...:.:|   |.....|.::::..|.::..|::::.|
Human   973 LKQHQETIN-TLKSKISEEVSR-NLHMEENT---GETKDEFQQKMVGIDKKQDLEAKNTQTLTAD 1032

  Fly  1039 ----TLVQQELQIMQ--RSAQRLRRHCEAALLERE----NHQDNGVLAVSLQEAL 1083
                .:::|:.:|..  :....|::..|:.:.|:|    :.::|..:.:..||.|
Human  1033 VKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEEL 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	144/405 (36%)
		KISc	120..525	CDD:214526	144/404 (36%)
		Kinesin_assoc	524..657	CDD:292801	45/245 (18%)
		FHA	634..740	CDD:238017	15/135 (11%)
CENPE	NP_001804.2	KISc	6..336	CDD:214526	144/404 (36%)
		KISc_CENP_E	6..329	CDD:276825	143/397 (36%)
		SbcC	345..915	CDD:223496	106/621 (17%)
		Mplasa_alph_rch	660..1366	CDD:275316	86/445 (19%)
		NUDE_C	828..>911	CDD:282704	17/86 (20%)
		Mplasa_alph_rch	1151..1951	CDD:275316
		Smc	1676..2482	CDD:224117
		Kinetochore-binding domain	2126..2476
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2355..2376
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2508..2533
		Globular autoinhibitory domain. /evidence=ECO:0000250	2510..2698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2588..2701
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910