DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and kif28p

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	XP_031758561.1	Gene:	kif28p / 101732886	XenbaseID:	XB-GENE-22065598	Length:	913	Species:	Xenopus tropicalis

Alignment Length:	992	Identity:	270/992 - (27%)
Similarity:	417/992 - (42%)	Gaps:	252/992 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 LMESCLSVSEESNMI----------VAVRVRPLNALE------CTRGQVTNVVQVHGNSNELTVQ 156
            |.:.||...|...::          |||||||.:..|      |.....||...:....|
Frog    21 LSKPCLESQESPKVVRNMPSYDSVKVAVRVRPFSKREKDASSKCVISMKTNCTTICDPKN----- 80

  Fly   157 AGSSADASAGVTHFFSYDQVYYSCDPERKN-------------FACQAKVFEGTARPLIDTAFEG 208
                    .|....|.:|..|:|.....||             :|.|..||:...:.::|.|::|
Frog    81 --------VGNEKTFKFDLAYWSHSEYLKNTESTLVPDGSYSRYADQKTVFQDLGQGILDNAWQG 137

  Fly   209 YNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVE 273
            |||.|.|||||||||||||:|...             ..||||..|.||||.||. ..::..|.:
Frog   138 YNATLLAYGQTGSGKSYSMIGYGT-------------NRGIIPLVCEELFRAIEN-NQEKNKQYQ 188

  Fly   274 VEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDS 338
            |..|..|||||::.||||                 :.::...|||||....|.||..|.....:|
Frog   189 VTFSMLEIYNEQVTDLLS-----------------KTKKSGGLKVREDQHQGFYVDGLKLVPCES 236

  Fly   339 YSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRR 403
            |:.:...:..|...|.||||:||..|||||.:..|......|..|                .|::
Frog   237 YAQIERLIEQGKKIRTTASTSMNASSSRSHMVITIQFKQILLKED----------------ITKQ 285

  Fly   404 SKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFV 468
            |.|:|||||||||...|.|.|:|:|||..:|.||.|||.||:|||::         ..|.....:
Frog   286 SSINLVDLAGSERQKSSASEGDRLREGTCVNLSLTTLGNVISALAEA---------AMGKKVLHI 341

  Fly   469 PYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNESPHDKII 533
            |||:||||.||:..|||||:|||:|.||||.|..:|||:|||||.:|:.|.|:..:|..|.:::|
Frog   342 PYRDSVLTKLLQSALGGNSRTVMIAAISPADICYEETLSTLRYAERAKKIKNKAIINAGPTERLI 406

  Fly   534 RDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSVDETEVEALRQQLA---ERERELSR 595
            ::|:||.::|.|         ||:|..|:.                   ::||:   |.|..:..
Frog   407 KELKAENNKLLS---------RLAGLGNSG-------------------KRQLSGCYENELRIQT 443

  Fly   596 AQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAEQKQACLVNLTADPILSGTLFYLLPQGLVRI 660
            .|.:|..:|:||..:.:.:...:.:....::|     ...|:|:..||.|||.|.:.:.:|...:
Frog   444 MQITWEHQLQEARKEWEQQYAAITQERRMMQL-----YPYLLNINEDPQLSGVLKHFIQEGASDV 503

  Fly   661 GRGRLPGGSSSSQPD--IVLDGPLVALQHCSIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLF 723
            |:          .|.  |.|.|..:..||.:..:.. .|::|.|..:. :..|||..:....:|.
Frog   504 GQ----------DPSNVITLRGLGILPQHATFINSE-SKVFVKPHGKG-KVIVNGVPIVLNTKLQ 556

  Fly   724 HGDRLVIG-GSHYFRISNPFCSQRGKAD---HPVDFQLAHQEILQKQEQQLRSELEAEKRAALTK 784
            |.||:::| .|.|..|..|  ::||..|   ...||              .:|||.|.:..::..
Frog   557 HLDRIILGSNSAYLYIGFP--AERGPDDLCRFDYDF--------------FQSELAAAEGFSVDT 605

  Fly   785 IEQERAQHAR----------DFEERLQCL-ELEQFKYKCNSEM-LETERQALALAQQQEHTPLRH 837
            :.....:..:          ||.:.:..: |..|...:.:.:: .|.:.:.|||...:.: .|:.
Frog   606 LGPVHNKEGKPDPSVLAVFHDFIKLMPLVAEANQMSEELSKDLKFELKVKNLALTDSRGY-DLQK 669

  Fly   838 EDAVSTPAQ---------------KSTILEDIQRIMLNPSEESLHK---------------TQLM 872
            |.:|....|               :..::|::.:..|:..:.||.:               :..:
Frog   670 EISVKVINQITNQVWIWSKSKFINRKFLMEELYQRYLDGGDISLDRESDPFWDPVEVIHLGSAHI 734

  Fly   873 VKEATQRCRQLDLPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPTARLGVWLDLVRDNAE-Q 936
            ..::...|.:|:...|...::..:|..|:..:....|.:|....|          |:|.|..| .
Frog   735 WLQSLAYCMKLEEQTELLNSEGVEEAILVINITPCSDTERPFGEE----------DIVIDPLELL 789

  Fly   937 QEKLN-ATTIFQSVEVDW------------------------EPLDADLNETLSDTHNSSRIALN 976
            ..|:. ...|.|.:.|.|                        :|:..::|..:.  |....:|||
Frog   790 GRKIEFQIHILQCLGVRWLKEATNRGIQIGYHFYDVCQCVYTKPVWKNVNPIID--HKLQFVALN 852

  Fly   977 LSAMKDVLLNKPLKRLL 993
            :|   :|||:...|..|
Frog   853 VS---NVLLSYLQKHAL 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	159/434 (37%)
		KISc	120..525	CDD:214526	159/433 (37%)
		Kinesin_assoc	524..657	CDD:292801	30/135 (22%)
		FHA	634..740	CDD:238017	30/108 (28%)
kif28p	XP_031758561.1	Motor_domain	42..398	CDD:419868	159/424 (38%)
		FHA	477..573	CDD:238017	29/107 (27%)
		KIF1B	691..725	CDD:403579	4/33 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010