Protein Alignment neb and kif14

DIOPT Version :9

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: XP_004913798.2
• Gene: kif14 / 100493263
• XenbaseID: XB-GENE-981231
• Length: 1609
• Species: Xenopus tropicalis
• Alignment Length: 1189
• Identity: 395/1189 - (33%)
• Similarity: 581/1189 - (48%)
• Gaps: 222/1189 - (18%)

  Fly    18 RGVHKSTPASEMRKKVLMTRAEDREHRDRPEQLLNTAFSGS-------TPQPKPKPTALNACYTP 75
            :|.....|..|  ||..:|:....:.:..| ||..|:.|.|       :||..||.....   .|
 Frog   233 KGSSLGKPGQE--KKTPVTKKNGLDQQRMP-QLGATSLSRSSSTRNIRSPQVTPKRVVAT---LP 291

  Fly    76 SSLYRNANSTPGRAKTPGTGKSS--CSRTKERDSLMESCLS---------VSEESNMIVAVRVRP 129
            :|..:| :||||...:..:.||:  |..:.|.....::..|         .:|...:.|||||||
 Frog   292 ASQKKN-SSTPGSVYSGRSEKSADVCLSSDEIQPKGDTAFSNFNLEEEHFKAENCAVTVAVRVRP 355

  Fly   130 LNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSCDPERKNFACQAKVF 194
            .:..|.....|..|..   |..|.|||...|..     .:.|.||..::|.:..:.:|..||.|:
 Frog   356 FSKREVNEKAVQVVFM---NGQETTVQHPDSKQ-----NYIFCYDFSFWSFEKSQPSFVGQASVY 412

  Fly   195 EGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIPRFCHELFR 259
            |..|.||::.:..|||.||||||||||||||:|||        .||.|     |||||||.:||.
 Frog   413 EKLAVPLLEWSLLGYNTCLFAYGQTGSGKSYTMMG--------FDGEP-----GIIPRFCSDLFS 464

  Fly   260 RIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPALKVREHPIF 324
            ||:|. .:|:|...:|:||||:|||||||||.             .:.:..|::..|||||||:.
 Frog   465 RIQAT-MKQKLSFHLEISYFEVYNEKIHDLLI-------------FKAENGQKKQPLKVREHPLT 515

  Fly   325 GPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSD 389
            ||||.|||.:.|.|:..:::||.:||.|||||:|.||||||||||:|.:|:..|.....||...|
 Frog   516 GPYVEDLSMNVVSSFQDIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEYVDGQEHD 580

  Fly   390 TDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAI 454
            .        |.|  |:|:|||||||||.|.:.::|||::||||||||||||||||:||:::.:.
 Frog   581 H--------RIT--SRINLVDLAGSERCSTAQTSGERLKEGVSINKSLLTLGKVISALSENSQT- 634

  Fly   455 ANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIV 519
                    ...||:|||||||||||:|:|||||||.|:||||||:.:.:|||:|||||.:||.|:
 Frog   635 --------RKKTFIPYRESVLTWLLKESLGGNSKTSMIATISPAATNMEETLSTLRYAKQARLII 691

  Fly   520 NRVKVNESPHDKIIRDLRAEVDRLK----SLRN-EYERQRRLSGNSNNPVPRKIIIETSVDETEV 579
            |..||||..:.||||:|:||::::|    |.:| :.|:.|:.                   ..||
 Frog   692 NVAKVNEDLNAKIIRELKAEIEKMKASQLSAKNKDSEKYRQC-------------------HQEV 737

  Fly   580 EALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAEQKQACLVNLTADPI 644
            .:|:.:|.::|||:|..:::|.:||::||.::|.|::.|::.|:..::  :.:...||||..||.
 Frog   738 TSLKLKLCQQEREMSELRRAWKDKLEQAEQRKKVEMQELQKAGITFKM--DNRLPNLVNLNEDPQ 800

  Fly   645 LSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVIPGSEDFET 709
            ||..|.|::.:|...:|:.:  .|||.   ||.|.|.|:|..||.|.:..  .:..|....|.:|
 Frog   801 LSEMLLYMIKEGQTTVGKYK--AGSSH---DIQLSGALIAEDHCIITNNE--NIVCIKPFGDAKT 858

  Fly   710 YVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKA-----DHPVDFQLAHQEILQKQEQQ 769
            ||||..:.....|.|||||::||.||||:::|....|..|     |.|.|::.|..|:|..|..|
 Frog   859 YVNGNQISGSTILHHGDRLILGGDHYFRVNHPMEVNRLNATTQVSDGPKDYEFAKNELLSAQRSQ 923

  Fly   770 LRSELEAEKRAAL------TKIEQERAQH------------ARDFEERL---------------- 800
            |..|:|..:..|.      .:|.:|.||.            .||.|.:|
 Frog   924 LAEEIEEARLRAKEEMMEGIQIAKEMAQQELTSQKFAYEEKIRDLEAQLKKESQHKELQEMNSQR 988

  Fly   801 ---QCLELEQFKYKCNSEM----LETERQALALAQQQEHTPLRHEDAV-STPAQKSTILEDIQRI 857
               :..|||:.|.....|:    ...|.:.||..|..|...:||...: :..|:|..|.:::|.:
 Frog   989 ATTRIQELEEMKIHLQQEVQFNKKRLEMETLATKQALEDHNVRHAKILQALEAEKQKIAKEVQML 1053

  Fly   858 M-----------LNPSEESLHKTQLMVKEATQRCRQLDLPLEFRQTQTPDEFGLLRTVILILDK- 910
            .           :.|:..:: |..:|::||.....:|.....|.:....|:..|....:.|..|
 Frog  1054 QRERNSQDRAMAVQPTWNNM-KLSVMIQEANSISSKLKKHTVFSRHDVTDKENLPTNPVQIQVKN 1117

  Fly   911 -QRGLKAEWPTARLGVWLDLVRDNAEQQEKLNATTIFQSVEVDWEPLDADLNETLSDTHNSSRIA 974
             :.|:...|...:....|..::|..|.........:|.....:|||   ||:.|     :.||.:
 Frog  1118 LKLGIVTYWSLEKFEYKLAAMKDLYENHGSTKDDDVFYDPGDEWEP---DLSNT-----SVSRFS 1174

  Fly   975 LNLSAMKD------------------------VLLNKPLKRLLNASSSKSNTPRQTSTPSPGSQL 1015
            ...|.||:                        .|:||. ...|:.|||.|:.|..:..|.
 Frog  1175 RRKSLMKNRRISGCLYEIRVHPIQSLQSGHASGLMNKS-SSFLSCSSSVSSNPSDSHLPG----- 1233

  Fly  1016 VHFTKRLLTYDPEEIPESQSSFTTLVQQELQIMQRSAQRLRRHCEAALLERENHQDNGVLA---- 1076
              ..|.|:....:.:..|....:.:....:..::|:...:|...:|...::|:..|...||
 Frog  1234 --ICKDLIASSLDYLGRSHVDESNMADSMIDSVKRACIGVRTVSQAYEQQKEDSTDMLFLANREA 1296

  Fly  1077 ----VSLQEALARMDTVLN 1091
                |.|..|..:: .|||
 Frog  1297 QSHSVQLTSAFQQL-VVLN 1314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	198/405 (49%)
		KISc	120..525	CDD:214526	198/404 (49%)
		Kinesin_assoc	524..657	CDD:292801	42/137 (31%)
		FHA	634..740	CDD:238017	43/105 (41%)
kif14	XP_004913798.2	KISc_KIF1A_KIF1B	347..697	CDD:276816	198/403 (49%)
		Kinesin_assoc	694..812	CDD:406567	43/138 (31%)
		FHA	792..889	CDD:238017	43/103 (42%)
		DUF5401	<910..>1065	CDD:375164	33/154 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1222
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	488	1.000	Inparanoid score	I1397
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	1	1.000	-	-		FOG0006888
OrthoInspector	1	1.000	-	-		otm47457
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4992
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.970