DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and kif13b

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	XP_031758942.1	Gene:	kif13b / 100492799	XenbaseID:	XB-GENE-956968	Length:	1943	Species:	Xenopus tropicalis

Alignment Length:	906	Identity:	302/906 - (33%)
Similarity:	446/906 - (49%)	Gaps:	197/906 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 ESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTH----FFSYDQVYY 178
            :|.:.||||:||:|..|... |...||.|..|.   .|...|:|..|.|...    .|:||..::
Frog     3 DSTVKVAVRIRPMNRREVDL-QTKCVVDVENNQ---IVLYPSNASLSKGDARSQPKVFAYDHCFW 63

  Fly   179 SCDPE-RKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGP 242
            |.|.. ::.||.|..||:.....::..||||||||:||||||||||||:|||..
Frog    64 SMDESVKEKFAGQDVVFQCLGENILQNAFEGYNACIFAYGQTGSGKSYTMMGTA----------- 117

  Fly   243 PHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQ 307
              |:.|:|||.|..||.|.:..:: ::|..:||||:.||||||:.|||
Frog   118 --DQPGLIPRLCSTLFERTQKAEN-EELSFKVEVSFMEIYNEKVRDLL----------------- 162

  Fly   308 QQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFN 372
            ..:..|.:||||||.:.||||..||..:|.||..:.:.::.||..|..|:|.||::|||||::||
Frog   163 DPKGSRQSLKVREHKVLGPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFN 227

  Fly   373 IVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSL 437
            |:|..|.:....|.|.:            :.||:||||||||||.:.:|:.|||::||.:|||||
Frog   228 IILTHTLVDVKSGTSGE------------KVSKLSLVDLAGSERATKTGAAGERLKEGSNINKSL 280

  Fly   438 LTLGKVIAALADSRKAIANGPLGSG-TPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIH 501
            .|||.||:||||.         |:| ..:.|||||:|||||||:::|||||||.|:||:|||:.:
Frog   281 TTLGLVISALADQ---------GAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADN 336

  Fly   502 ADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPR 566
            .||||:|||||.:|::|||...|||.|:.:|||:||.||::|:
Frog   337 YDETLSTLRYADRAKNIVNHAVVNEDPNARIIRELREEVEKLR---------------------- 379

  Fly   567 KIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE---LT 628
              :..|..:..:...|:::|.|.|:.:.....:|.|||:..||..:...:.|:..|::|:   :.
Frog   380 --VQLTQAESMKAPELKERLQESEKLIQEMTVTWEEKLRMTEDIAQERQKQLESLGISLQSSGIK 442

  Fly   629 AEQKQACLVNLTADPILSGTL-FYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEH 692
            ....::.||||.|||.|:..| :||....|:         ||..|| ||.|.|..:..:||.|:.
Frog   443 VGDNKSFLVNLNADPALNELLVYYLKDHTLI---------GSHDSQ-DIQLCGLGILPEHCIIDI 497

  Fly   693 ERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNP---------------- 741
            ...|::.:.| .::..|||||..:....||.||||::.|.:|:||||.|
Frog   498 SPEGQVILTP-MKNTRTYVNGSAVTKATQLQHGDRILWGNNHFFRISLPKKKKAKQEDEEQDSSL 561

  Fly   742 -------------FCSQRGKADHPVDFQLAHQEILQKQ----------EQQLRSELEAEKRAALT 783
                         ..|..|.::...:::.|..||:.|.          .|.|..:.|.|||:||
Frog   562 RNSSSFEQLDLDGDSSSEGSSEVNFNYEYAQMEIMMKALGNNDPMQSILQSLEQQHEEEKRSAL- 625

  Fly   784 KIEQERAQHARDFEERLQCLELEQFKYKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQKS 848
              |::|..:..         ||:|.:.:              |:.:::|.......:..:|..:.
Frog   626 --ERQRLMYEH---------ELDQLRRR--------------LSPEKQHYRSMDRFSFGSPNAQQ 665

  Fly   849 TILE--DIQRIMLNPS----EESLHKTQLMVKEATQRCRQLDLPLEFRQT-QTPDEFGLLRTVIL 906
            .|.:  :.:..|||.|    .|.:.|..|.|:||.....::|...|::.| |.|       ...|
Frog   666 RIRQWTEEREAMLNQSLRKLREQIAKANLHVQEANFIAEEMDKRTEYKVTLQIP-------ASSL 723

  Fly   907 ILDKQRGLKAEWPTARL-------GVWLDLVRDNAEQQEKL-NATTIFQSVEVDWEPLDAD 959
            ..:|:||.....|..::       .:|         ..||| |.....:.:..:|:..|.|
Frog   724 NANKKRGAVLSEPAIQVRRKGKGKQIW---------SLEKLENRLVDIRDLYQEWKECDED 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	182/411 (44%)
		KISc	120..525	CDD:214526	181/410 (44%)
		Kinesin_assoc	524..657	CDD:292801	37/136 (27%)
		FHA	634..740	CDD:238017	41/106 (39%)
kif13b	XP_031758942.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	182/411 (44%)
		Kinesin_assoc	357..469	CDD:406567	37/135 (27%)
		FHA	449..544	CDD:238017	41/105 (39%)
		KIF1B	755..801	CDD:403579	5/21 (24%)
		DUF3585	<1097..1141	CDD:419985
		DUF3694	<1185..1277	CDD:403614
		CAP_GLY	1810..1873	CDD:396049
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920