DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and LOC100491511

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	XP_031749449.1	Gene:	LOC100491511 / 100491511	-ID:	-	Length:	2330	Species:	Xenopus tropicalis

Alignment Length:	1024	Identity:	308/1024 - (30%)
Similarity:	476/1024 - (46%)	Gaps:	194/1024 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 VSEESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTH----FFSYDQ 175
            :||.||:.|||||||:|..|..:..| .|:.:.|....|.    |:|..|.|...    .|:||.
Frog     1 MSERSNVRVAVRVRPMNQREKEKHPV-GVISMSGTKTILQ----SNATVSPGKVQKGPKEFTYDH 60

  Fly   176 VYYSC-DPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALD 239
            .::|. |.:...:|.|.:||:......|:..::|||.|:||||||||||:|:|||.:
Frog    61 CFWSADDSDPDTYAGQEEVFKTLEEGTIENIYQGYNVCIFAYGQTGSGKTYTMMGRD-------- 117

  Fly   240 GGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTP 304
                 ||.|:|||||..|..|    ||:.  .|.||:||.||||||:.|||.:
Frog   118 -----DEPGLIPRFCRALLNR----KSKG--TVRVELSYMEIYNEKVRDLLEL------------ 159

  Fly   305 IQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHS 369
                 ::.:..|.||||.|.||||..||.|:|.::..::..|..||..|.||:|.||::|||||:
Frog   160 -----KKSKKELSVREHNILGPYVEGLSQHAVSTWEDIKLLLLAGNKCRTTAATKMNEESSRSHA 219

  Fly   370 IFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSIN 434
            ||.:.:            :....:.||...:...||.:|||||||||.|.||:.|:::.|..:||
Frog   220 IFTLAI------------TQMFPNQASGTSKELHSKFNLVDLAGSERASKSGAQGKQLVESGNIN 272

  Fly   435 KSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPAS 499
            |||.:||::|::||:.:         ....|::|.||||||||||:.:||||||||||||||||.
Frog   273 KSLTSLGRIISSLAECK---------GRRSSSYVSYRESVLTWLLKNSLGGNSKTVMLATISPAE 328

  Fly   500 IHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPV 564
            .:..||.:||.||.:||.|||:..|||....|.:..|:.||..||       .|.:.:.:..:|
Frog   329 DNYGETHSTLVYAERARKIVNQATVNEDTKCKAVATLQKEVQNLK-------EQLKRAKSQQSP- 385

  Fly   565 PRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE--- 626
                            .|:.:|.|.|..|.:...||.||||:.|:..|...:.|:..|::::
Frog   386 ----------------ELQSKLKESENLLKQLNLSWEEKLKKTEENAKLMQKYLESMGISVDASG 434

  Fly   627 LTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIE 691
            :...::|.|||||..||..:..|.|.|..      ..::..|||.   |..|.||.:..:||.|.
Frog   435 IKCAKEQCCLVNLNPDPESNDYLLYYLTD------HNKIGAGSSQ---DFQLTGPGIEEEHCVIT 490

  Fly   692 HERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPVDFQ 756
            ....|.::::|.::. ||.|||.|:::..||:|.|::.:|.::.|.::.|      |...|
Frog   491 MTPDGDVFLVPSTKT-ETKVNGALVQESIQLYHEDKINLGLNYSFILNQP------KKRQP---- 544

  Fly   757 LAHQEILQKQEQQLRSELEAEKRAALTKIEQERAQHARDFEERLQCLELEQFKYKCNSEMLETER 821
               ..:.:.:.:..::|:..:..:    |.:...:|    |..:|    ||..|...|...:.:.
Frog   545 ---NSLSENKHKVEKNEMSTDHES----INESNPKH----ESGIQ----EQHPYYQLSGSQDDDN 594

  Fly   822 QALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQRI--MLNPSEESLHKTQLMVKEATQRCRQLD 884
            :   |.:.....|.:.|.:..:.:..|.....|:::  :|..|:|||.:.|       |....|.
Frog   595 E---LTKTFHINPKKEEISTESRSHDSHSTSSIEKVLALLQKSQESLTELQ-------QNFTNLV 649

  Fly   885 LPLEFRQTQTPDEFGLLRT---VILILDKQRGLKAEWPTARLGVWLDLV--------RDNAEQQE 938
            ..||.:|..|..:...|..   |:|..:....:.||........:|||:        :||.:.::
Frog   650 EKLESKQLITQQDCAGLENKEDVVLKYEILLNIIAEKGENACTEFLDLLGKDKVDMNKDNDDDRK 714

  Fly   939 KLNATTIFQSVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKDVLLNKPLKRLLNASSSKSNTP 1003
            :.|..|  ::.:...:| :.|.||.......:.  |||..:......|...:...|...||:::.
Frog   715 EQNTET--ETAKDQSQP-NNDKNEVAEKEETTE--ALNEKSDVAKTENGAEREEENTGPSKNHSD 774

  Fly  1004 RQTSTPSPGSQLVHFTKRLLTYDPEEIPESQSSF--TTLVQQELQIMQRSAQRLRRHCEAALLER 1066
            ..|...|                .:|..|..:|.  .||.:..|:.|....           .|.
Frog   775 NDTKKNS----------------EDECTEENTSIDKKTLYRDLLKKMNMDP-----------YEM 812

  Fly  1067 ENHQDNGVLAVSLQEALARMD------TVLNGMHTSLA-RAEATACVTS 1108
            :|.....:|.:. ||.|.:||      ..:|.:|..:| ...|.:.:||
Frog   813 KNLTLQDILQID-QECLEKMDNWQRKSAAMNFIHKIIALNGTARSIITS 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	170/410 (41%)
		KISc	120..525	CDD:214526	169/409 (41%)
		Kinesin_assoc	524..657	CDD:292801	37/135 (27%)
		FHA	634..740	CDD:238017	34/105 (32%)
LOC100491511	XP_031749449.1	Motor_domain	5..354	CDD:419868	170/410 (41%)
		Kinesin_assoc	<384..463	CDD:406567	27/95 (28%)
		FHA	466..528	CDD:395400	22/65 (34%)
		PRK08581	544..>796	CDD:236304	55/301 (18%)
		CARD	641..701	CDD:260018	15/66 (23%)
		P-loop_NTPase	1387..>1516	CDD:422963
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010