Protein Alignment neb and kif16b

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: XP_012819297.1
• Gene: kif16b / 100489716
• XenbaseID: XB-GENE-948787
• Length: 1837
• Species: Xenopus tropicalis
• Alignment Length: 1025
• Identity: 322/1025 - (31%)
• Similarity: 503/1025 - (49%)
• Gaps: 182/1025 - (17%)

  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELT---VQAGSSADASAGVTHFFSYDQVYYSCDPER 184
            |||||||:|..|... :...::::.|....:|   :..|.|.|.....|..|:||..|:|.|.:.
 Frog     6 VAVRVRPMNRREKDL-EAKFIIEMEGKKTTITNIKMPDGISGDLGRERTKTFTYDFSYFSVDSKN 69

  Fly   185 KNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGI 249
            .::|.|.:||:.....::.:||||||||:||||||||||||:||            |.|.| :|:
 Frog    70 IDYASQERVFKDLGTDVLQSAFEGYNACIFAYGQTGSGKSYTMM------------GNPGD-SGL 121

  Fly   250 IPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRP 314
            |||.|..||.||.............||||.|||||::.|||                :::..:..
 Frog   122 IPRICEGLFSRIAETTRWGDASFRTEVSYLEIYNERVRDLL----------------RRKSSKTF 170

  Fly   315 ALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTD 379
            .|:|||||..||||.|||.|.|.:|..:...:..||..|.||:|.|||.|||||:||.|  |.|.
 Frog   171 NLRVREHPKEGPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTI--NFTQ 233

  Fly   380 LSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVI 444
            ...|..:..:|            .|||.|||||||||...:|:.|.|::||.:|||||:|||.||
 Frog   234 AKFDAEMPCET------------VSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVI 286

  Fly   445 AALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATL 509
            :||||..:..||..  :.....|||||:|||||||:::|||||||:|:||||||.|:..|||:||
 Frog   287 SALADLSQDAANHL--AKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADINYGETLSTL 349

  Fly   510 RYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSV 574
            |||.:|::|:|:..:||..:.|:||:||||:.|||:|..:        ||       :|.:   :
 Frog   350 RYANRAKNIINKPTINEDANVKLIRELRAEIARLKALLAQ--------GN-------QIAL---L 396

  Fly   575 DETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAEQKQACLVNL 639
            |.....::.::|.:.|..:....|.|..|..|.::..|.:...|::.|:.:.|.:|...  |:.:
 Frog   397 DSPTALSMEEKLQQNEARVEELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSELPH--LIGI 459

  Fly   640 TADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVIP-- 702
            ..|.:.:|.:.|.|.:|...:||     ..:::..||||.|..:..:||..|: ..|.:.:||
 Frog   460 DDDLLSTGIILYHLKEGRTYVGR-----EDAAADQDIVLHGLDLESEHCIFEN-LSGTVTLIPLN 518

  Fly   703 GSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNP----FCSQRGKADHPVDFQLAHQEIL 763
            ||   :..|||..:::..||..|..:::|.::.||.::|    ...::.|:.....|.|:..: |
 Frog   519 GS---QCSVNGVQIQESTQLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTD-L 579

  Fly   764 QKQEQQLRS--------ELEAEKRAALTKIEQERAQHARDFEE--RLQCLELEQFKYKCNSEMLE 818
            .|..:.|.:        |.|.::|..|.|:|.:| :..::.||  :.:..|||:.:.:..|:..|
 Frog   580 SKSCENLSAVMLYNPGLEFERQQREELEKLENKR-KLIKEMEEKQKYEKAELEKMQQEVESQRKE 643

  Fly   819 TERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQRIMLNPSEESLHKTQ------------- 870
            ||...|.:.:|:|....|..|..|.       |:|:....:...||.|.:.|
 Frog   644 TEIVQLHIRKQEESLKRRSLDIESR-------LQDLLAEKIKFEEERLREQQEIELQKKKQQEES 701

  Fly   871 -LMVKEATQRCRQLDLPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPTARLGVWLDLVRDNA 934
             :.|:|..||.::|      ..|:..::..:.|.    |:|   ||.|.....|.  |:..:...
 Frog   702 FIKVQEELQRLQEL------HNTEKGEKMEIFRE----LEK---LKKEKDDQYLK--LEAEKKRL 751

  Fly   935 EQQEKLNATTIFQSVEVDWEPLDADLNE-----TLSDTHNSSRIALNLSAMKDVLLNKPLKRLLN 994
            |:||:.....:|:        |:..|.|     .|.:..:.||:...:..::||     .:.||.
 Frog   752 EEQEREQLKLVFR--------LEEQLREKQEMILLFERGDVSRLEEEIGVLEDV-----REDLLR 803

  Fly   995 ASSSKSNTPRQTSTPSPGSQLVHFTKRLLTYDPEEIPESQSSFTTLVQQELQIMQRSAQRLRRHC 1059
            |..::|.        ..|             ||||:.::.:.:|..  :.:|:.:.|......|.
 Frog   804 AKEARSE--------GEG-------------DPEEVEKATNKYTEF--KRMQVDKLSVLEGDLHR 845

  Fly  1060 EAALLERENHQDNGVLAVSLQEALARMDTVLNGMHTSLARAEATACVTSP 1109
            :...||:|...|:        :.|:|: .:.|..:|.|.:.|..:.:.:|
 Frog   846 QTDCLEKEIKADH--------DTLSRL-CLSNVENTELHKTEDESSLVTP 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	179/404 (44%)
		SMC_N	514..>615	CDD:481474	27/100 (27%)
		FHA_KIF14	627..741	CDD:438759	32/115 (28%)
kif16b	XP_012819297.1	KISc_KIF1A_KIF1B	2..365	CDD:276816	179/404 (44%)
		Kinesin_assoc	364..476	CDD:465047	33/131 (25%)
		FHA_KIF16B	446..562	CDD:438784	33/126 (26%)
		Smc	<600..>1077	CDD:440809	76/355 (21%)