Protein Alignment neb and kif1b

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: XP_012822406.1
• Gene: kif1b / 100379810
• XenbaseID: XB-GENE-1013591
• Length: 1810
• Species: Xenopus tropicalis
• Alignment Length: 1160
• Identity: 338/1160 - (29%)
• Similarity: 520/1160 - (44%)
• Gaps: 301/1160 - (25%)

  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYS----CDPE 183
            |||||||.|:.|.:: :...::|:.|||..: :...:..:|:..    ||:|..|:|    .||
 Frog     8 VAVRVRPFNSRELSK-ESKCIIQMQGNSTSI-INPKNPKEAAKS----FSFDYSYWSHTSQDDP- 65

  Fly   184 RKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAG 248
              .||.|::|:....:.:::.||||||.|:|||||||:||||:|||.:           ...:||
 Frog    66 --CFASQSRVYNDIGKEMLEHAFEGYNVCIFAYGQTGAGKSYTMMGKQ-----------EETQAG 117

  Fly   249 IIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQR 313
            |||:.|.:||.:|.. .:..::...|||||.|||.|::.|||:                  .:.:
 Frog   118 IIPQLCEDLFEKIND-NNNDEVSFSVEVSYMEIYCERVRDLLN------------------PKNK 163

  Fly   314 PALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLT 378
            ..|:|||||:.||||.|||..:|.||:.:.:.:..||..|..|:|.||:.|||||::|.||....
 Frog   164 GNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQK 228

  Fly   379 DLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKV 443
            .|.....||::            :.|||||||||||||...:|:.|.|::||.:|||||.|||||
 Frog   229 RLDIGTNLSTE------------KVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKV 281

  Fly   444 IAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLAT 508
            |:|||:.....:.......|  .|:|||:|||||||||||||||:|.|:|.:|||.|:.||||:|
 Frog   282 ISALAEVDNCTSKSKKKKKT--DFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLST 344

  Fly   509 LRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLK----------------------------- 544
            ||||.:|:.|.....:||.|:.|::|:|:.||.|||
 Frog   345 LRYADRAKQIKCNAVINEDPNAKLVRELKDEVTRLKDLLRAQGLGDILDTLPSVGCFPISDMNDN 409

  Fly   545 -SLRNEY----ERQRRLSGN-------SNNPVPRKIIIETSVDETEVEALR-------------Q 584
             :|:|:|    |.||  .||       |....|....:.:.|..|.|.:::             :
 Frog   410 ENLKNKYLLANENQR--PGNFSTASISSLASSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIE 472

  Fly   585 QLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLA-------LELTAEQKQACLVNLTAD 642
            :|.|.|:.::...::|.|||::.|..|.....:|...|:|       |.:.:.:|...||||..|
 Frog   473 RLKESEKIIAELNETWEEKLRKTEAIRMDREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNED 537

  Fly   643 PILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVI----PG 703
            |::|..|.|.:..||.|:|:     ..:.|:.||||.|..:..:||....||.....||    ||
 Frog   538 PLMSECLLYYIKDGLTRVGQ-----ADADSRQDIVLSGAHIKEEHCIFRSERNSNGEVIVTLEPG 597

  Fly   704 SEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKAD-----------HPVDFQL 757
            ... ||||||:.:....:|..|:|:::|.:|.||.::|   ::.:|:           .|||:..
 Frog   598 DRS-ETYVNGKRVVHPVELRSGNRIIMGKNHVFRFNHP---EQARAEREKTPSAETPSEPVDWTF 658

  Fly   758 AHQEILQKQEQQLRSELE--AEKRAALTKIEQERA-----QHARDFEERLQCLELEQFKYKCNSE 815
            |.:|:|:||...::.|:|  .::...|.|.|:|.|     |...|:|.:||.|   |.:.:.:|.
 Frog   659 AQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQAL---QKQVETHSL 720

  Fly   816 MLETERQALALAQQQEHTP-LRHEDAVSTPAQKS------TILEDIQRIMLNPSEESLHKTQLMV 873
            ..||....   .:::|..| .:||..|:..|.|.      |.|.|:           |....:.:
 Frog   721 AAETTDDG---EEEEEEVPWTQHEYDVALWAFKKWRNHQFTSLRDL-----------LWGNAMYL 771

  Fly   874 KEATQRCRQLDLPLEFR--------------------QTQTPDEFGLLRTVIL--ILDKQRGLKA 916
            |||.....:|...::|:                    ..:|.::....|||:.  :.|.:.|...
 Frog   772 KEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPSDADKTTEDRTFPRTVVAVEVQDLKNGATH 836

  Fly   917 EWPTARLGVWLDLVRDNAE---------QQEK-------------------LNATTIF------- 946
            .|...:|.:.|:.:|:..:         |.|.                   :.::.||
 Frog   837 YWSLEKLRLRLEQMREMYDRAGEMASHVQDENDTVITGNDPFYDRFHWFKLVGSSPIFHGCVNER 901

  Fly   947 --------------------------QSVEVDWEPLDADL---------NETLSDTHNS------ 970
                                      |..:.|.||...|.         ::..||.|:.
 Frog   902 LADRTPSPTFSTADSDITELADEQQDQMEDFDDEPFVDDTGSDVGAEEGSDLFSDGHDPFYDRSP 966

  Fly   971 -----SRIALNLSAMKDVLLNKPLKRLLNASSSKSNT-----------PRQTSTPSPGSQLVHFT 1019
                 .|..:.||   ::|...||.......|.|...           ......|..||.:....
 Frog   967 WFILVGRAFVYLS---NLLFPVPLVHRAAIVSEKGEVRGFLRVAVQAISGDEEAPDYGSGIRQSG 1028

  Fly  1020 KRLLTYDPEEIPESQSSFTTLVQ-----QELQIMQRSAQRLRRHCEAALLERENH 1069
            ...:::|.|.|.:::.|...|.:     :||:|::...|    :.:...||..||
 Frog  1029 TAKISFDNEYINKNEISSMVLTRSGLSLEELRIVEGQGQ----NSDITSLEEVNH 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	171/405 (42%)
		SMC_N	514..>615	CDD:481474	35/154 (23%)
		FHA_KIF14	627..741	CDD:438759	41/117 (35%)
kif1b	XP_012822406.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	171/405 (42%)
		Kinesin_assoc	358..552	CDD:465047	47/195 (24%)
		FHA_KIF1B	527..636	CDD:438779	42/117 (36%)
		GimC	659..>716	CDD:440992	19/59 (32%)
		KIF1B	843..890	CDD:463574	5/46 (11%)
		KIF1B	<954..973	CDD:463574	3/18 (17%)
		DUF3694	1262..1407	CDD:463599
		PH_KIFIA_KIFIB	1691..1793	CDD:269939