DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and kif16ba

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	XP_009292601.2	Gene:	kif16ba / 100334507	ZFINID:	ZDB-GENE-090313-233	Length:	1356	Species:	Danio rerio

Alignment Length:	1045	Identity:	321/1045 - (30%)
Similarity:	502/1045 - (48%)	Gaps:	196/1045 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 VAVRVRPLNALE------CTRGQVTNVVQVHGNS---NELTVQAGSSADASAGVTHFFSYDQVYY 178
            |||||||:|..|      |       ::::.||.   :.|.:..|.:.|:....|..|:||..|.
Zfish     6 VAVRVRPMNRREKDLSGKC-------IIEMEGNKTTISNLKIPDGVTGDSVREKTKTFTYDFSYD 63

  Fly   179 SCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPP 243
            |.|.:...|..|.|||:.....::.:||||||||:|||||||||||::||||            |
Zfish    64 SSDCKNACFVSQEKVFKDLGTDVLKSAFEGYNACIFAYGQTGSGKSHTMMGI------------P 116

  Fly   244 HDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQ 308
            .| .|:|||.|..||.||..:..:.:.....||||.|||||::.|||                ::
Zfish   117 GD-LGLIPRICEGLFSRISGMTRRDEASFRTEVSYLEIYNERVRDLL----------------RR 164

  Fly   309 QQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNI 373
            :..:...|:|||||..||||.|||.|.|.:||.:...:..||..|.||||.|||.|||||:||.|
Zfish   165 KMAKTYNLRVREHPKEGPYVEDLSKHLVQNYSDVEELMEAGNINRTTASTGMNDASSRSHAIFTI 229

  Fly   374 VLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLL 438
              |.|....|..:.|:|            .|||.|||||||||...:|:.|.|::||.:|||||:
Zfish   230 --NFTQAKFDAEMPSET------------VSKIHLVDLAGSERADATGATGVRLKEGGNINKSLV 280

  Fly   439 TLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHAD 503
            |||.||:||||..:...|..|..  ...|||||:|||||||:::|||||||:|:||||||.::..
Zfish   281 TLGNVISALADLSQEGGNSQLKK--KQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADVNYG 343

  Fly   504 ETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKI 568
            |||:|||||.:|::|:|:..:||..:.::||:||||:.|||:|..:        ||       :|
Zfish   344 ETLSTLRYANRAKNIINKPTINEDSNVRLIRELRAEIARLKALLAQ--------GN-------QI 393

  Fly   569 IIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAEQKQ 633
            .:   :|.....::.::|...|..:....|.|..|..|.::..|.|...|::.|:.:.|.:|...
Zfish   394 AL---LDSPTALSMEEELHHNEARVLELTKEWTNKWNETQNILKEETLALRKEGIGVILDSELPH 455

  Fly   634 ACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKL 698
              |:.:..|.:.:|.:.|.|.:|...:||     ..::::.||:|.|..:..:||.|| .:.|.:
Zfish   456 --LIGIDDDLLSTGIILYHLKEGRTYVGR-----DDATTEQDIILHGLGLESEHCLIE-SQNGTV 512

  Fly   699 YVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNP----FCSQRGKADHPVDFQLAH 759
            .:|| ..|.:..|||..:.:..||..|..:::|.::.||.::|    ...::.|:.......|:.
Zfish   513 TLIP-LNDAQCSVNGVQITEPCQLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLTSLSLSM 576

  Fly   760 QEILQKQEQQ------------------LRSELEAEKRAALTKIEQERAQHARDFEERLQC--LE 804
            .::.:..|..                  ||.|.|.::|..|.|:|.:| :..::.||:.:|  :|
Zfish   577 SDLSKSCENLSTVMLYNPGLFTEKGPIFLRLEFERQQREELEKLENKR-RLIKEMEEKQKCEKVE 640

  Fly   805 LEQFKYKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQRIMLNPSEESLHKT 869
            ||:.:.:..|:..|:|:....:.:|:|....|.:|..|   :...::.:.||.     :|..|:.
Zfish   641 LERMQQEVESQRKESEQVQQRIRRQEESLRRRSQDIES---RLRDLIAEKQRF-----QEERHRD 697

  Fly   870 QLMVKEATQRCRQLDLPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPTARLGVWLDLVRDNA 934
            |   ||..:: :||...||.::....:|..        |::....:|:             |:.|
Zfish   698 Q---KEQEEQ-KQLKQELEEKEKDEEEEED--------LEEDEKTQAQ-------------RERA 737

  Fly   935 EQQEKLNATTIFQSVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKDVLLNKPLKRLLNASSSK 999
            ||      |.:|:.:            |.|........:.|.|...:   |.:..|..|......
Zfish   738 EQ------TELFREL------------ERLKREREEQAVKLQLERRR---LEEREKEQLCLVGRL 781

  Fly  1000 SNTPRQTSTPSPGSQLVHFTKRLLTYDPEEIPESQSSFTTLVQQELQIMQRSAQRL--------- 1055
            ....|:.|..:         ..|||  |:|....|....||.:.:.::::....|:
Zfish   782 EEQLRERSEEA---------SALLT--PDEARRLQEERRTLAELKEELLRAKEARIDGEEEESGD 835

  Fly  1056 --RR--HCEAALLERENHQDNGVLAVSLQEALARMDTVLNGMHTSLARAEATACVTSPTKTQKAV 1116
              ||  |......::...::..:|..||.:...|::..|:...|:|     |..:.|....|:.|
Zfish   836 AARRSAHTRYHQFKQTQLEELELLEDSLMQQRDRLERELDHERTAL-----TLMMHSHKDKQRQV 895

  Fly  1117 RFLID 1121
            |.|::
Zfish   896 RDLME 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	183/410 (45%)
		KISc	120..525	CDD:214526	183/410 (45%)
		Kinesin_assoc	524..657	CDD:292801	33/132 (25%)
		FHA	634..740	CDD:238017	29/105 (28%)
kif16ba	XP_009292601.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920