DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10730 and CG31933

DIOPT Version :9

Sequence 1:	NP_610021.3	Gene:	CG10730 / 35291	FlyBaseID:	FBgn0032843	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_722734.1	Gene:	CG31933 / 326176	FlyBaseID:	FBgn0051933	Length:	673	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	163/546 - (29%)
Similarity:	246/546 - (45%)	Gaps:	66/546 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 VPNNTDYMITSCYVRDVTKHRELLQQDAISFIE---DRLPKE-----KVKDFVKDESEVHKP-SV 190
            ||....:|...|.   .|...:.|..||..||:   ::|.|:     |..|..|..|....| ||
  Fly   148 VPKGLRHMRVKCL---NTFTNKTLHDDAHFFIQPPPEKLLKKPPATLKYWDGEKHSSGATSPISV 209

  Fly   191 LIMGLDSTSRINLRRAMPSVYKFVRQ-PGWFEMQGYNKVGDNTFPNLLAALTGDSEKGVGDYCDV 254
            :|:||||.|.:||.|.||...:::|| ....|..|:||:|.||:|||:|.|||.|......|.
  Fly   210 MILGLDSVSHLNLLRQMPRTVRYMRQNMSQVEFWGFNKIGTNTYPNLIALLTGLSAAESEAYW-- 272

  Fly   255 TKPGCLDSLNFIWKRFKKANYTTAFAEDCSSISTFNYLKPGFVKQPTDYYLRPLL--FAIEKQFK 317
            .:..|:|:|..|||.||:|.|.|:||||.:..|.|.:.||||.:..||..|...:  ..|.:|..
  Fly   273 VRQKCMDNLPLIWKEFKRAGYNTSFAEDMAIYSMFYFGKPGFKRPTTDNNLHDFMVDLYINRQAS 337

  Fly   318 VTNDFGFAYCVGRHLSFSYVWDFGQQFIDRFL---GRSPMFGFL-WSNSFTHDYYEGATALDNLL 378
            ..:|   .:|:|.......:.:..    ||.|   .|.|.|.|. |:|.| |:::......|...
  Fly   338 SVSD---THCMGERAFMDILLEMN----DRLLPHTQRYPFFSFYWWANGF-HEFFNSPRLADGRF 394

  Fly   379 WKYLKSFEESNLFQKSIVILMSDHGHRYNTLRRASTGYFEERMPMMFIYLPPWFRRKYPHLASNL 443
            .:.|:|.:::.:...:|:..|||||.|:...|.:..|..|:..|.:.:..|.|.|.|||....:|
  Fly   395 ERLLRSLDDAGITNNTIIFFMSDHGLRWGLFRSSFQGMIEDSQPFLSVLYPKWMRLKYPMAIKSL 459

  Fly   444 GKNQNRLSSNYDVYMTLQHLLQ---LDSKSVDEFPD---NLRARQCKSCQSLFFELPFNRTCQMA 502
            ..|.:.|.:.||::.||:|:|:   |:..|:.:..:   .|:..|.....|||..:|..|.|..:
  Fly   460 VGNAHSLVTTYDLHETLKHILEPSSLEDTSITQKTEELWKLKGSQTPRAVSLFLPIPPWRNCNTS 524

  Fly   503 GIEEKWCCCQPTETITNSPHVST-IAEAIVQRMNEHLISHNLSDLCHNFTLD------------- 553
            .|..|:|.|.....|..|..|.| .|..|:..:|:.::.:   .:|....||
  Fly   525 HIPSKFCLCHKQIPIPESNRVVTKSASIIIDYVNQLMVEY---PVCIPLQLDSIESAYFAAPQRD 586

  Fly   554 ---YVEKADRKTILSNGLRPADKNEQV----YIIVFETVPKNPIFEATVRWNSRTQRLLHFDVEE 611
               |:||..:......|  |..|.::.    .::..:|.|.|..||...|.......|    |.|
  Fly   587 DDFYIEKGHKNVYPEKG--PFWKKQKYEDRDIVVRLKTKPGNAYFEGMTRRQGSKLSL----VGE 645

  Fly   612 LSRLTSYKNDAN-CINRKNAKKYCIC 636
            :.|:....|..| ||:....:.:|.|
  Fly   646 VVRVGGEGNRNNDCIDNPLLEPFCHC 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10730	NP_610021.3	DUF229	55..556	CDD:281053	142/459 (31%)
CG10730	NP_610021.3	ALP_like	188..467	CDD:293745	101/289 (35%)
CG31933	NP_722734.1	DUF229	114..576	CDD:281053	141/443 (32%)
CG31933	NP_722734.1	ALP_like	208..483	CDD:293745	100/284 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466475
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31599at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950