DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10730 and T07G12.3

DIOPT Version :9

Sequence 1:	NP_610021.3	Gene:	CG10730 / 35291	FlyBaseID:	FBgn0032843	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_501945.2	Gene:	T07G12.3 / 188242	WormBaseID:	WBGene00011594	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	549	Identity:	143/549 - (26%)
Similarity:	231/549 - (42%)	Gaps:	104/549 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 PNNTD--YMITSCYVRDVTKHRELLQQDAISFIEDRLPKEKVKDFVKDESEVHKPSVLIMGLDST 198
            |.:.|  ::.|.|:..::..:..:..|    .|..:....|.||         .|:|.|..:|:.
Worm   120 PGHVDCEFLETVCWEDNIEVYGHIHTQ----IIPRKASPTKFKD---------APNVFIFTIDAM 171

  Fly   199 SRINLRRAMPSVYKFVRQPGWFEMQGY---NKVGDNTFPNLLAALTGDSEKG----VGD------ 250
            :....:|:.|.:..:.:..  |:|..:   ||||:|:.||.|....|.|.:|    .||
Worm   172 NTGMAKRSFPKLLSYFKNE--FQMIEFPFVNKVGENSRPNGLPLWFGKSIEGGRRVTGDDVEVDW 234

  Fly   251 ----YCDVTKPGCLDSLNFIWKRFKKANYTTAFAEDCSSISTFNYLKP---GFVKQPTDYYLRPL 308
                ||:.    .||:.:.|:|.||...|.|...||.......::  |   ||.:.|||:..||.
Worm   235 DWNQYCET----YLDNSSHIFKDFKDHGYATMLFEDWEGNVVDSW--PTCVGFEEPPTDHTFRPF 293

  Fly   309 LFAIEKQ-FKVTNDFGFAYCVGRHLSFSY-------VWDFGQQFIDRFLGRSPMFGFLWSNSFTH 365
            ....|.. .::|.         ||||..:       :.:..:|.|:.:..| |:|.:||.....|
Worm   294 ASVSETHGMEITK---------RHLSGKFCRETHHAIMELLEQGIEAYKDR-PIFSWLWLAWVAH 348

  Fly   366 DYYEGATALDNLLWKYLKSFEESNLFQKSIVILMSDHGHRYNTLRRASTGYFEERMPMMFIYLPP 430
            |:.:||..:|..|..|.|  :.:|:|..|.|:.:||||.|.....|...|.||...|.:.|.:|.
Worm   349 DWIDGAARVDEYLVNYFK--KHNNMFDNSFVMFVSDHGLRTGKHMRTEIGAFERDNPFLSISIPK 411

  Fly   431 WFRRKYPHLASNLGKNQNRLSSNYDVYMTLQHLLQLDSKSVDEFPDNLRARQCKSC-----QSLF 490
            .||.....:...|..:..:|.:::||..||..:|:....|  :|.|    ||.|:.     .||.
Worm   412 RFRATKFGILETLNFDSKQLQTHFDVRATLLDILKFQPTS--KFMD----RQQKNIPDEKGHSLI 470

  Fly   491 FELP-FNRTCQMAGIEEKWCCCQ------PTETITNSPHVSTIAEAIVQRMNEHLISHNLSDLCH 548
            .:.| |.|||....|.::||.||      ..||:.|.     :.|.::..::..|...|:|::|.
Worm   471 RKQPDFPRTCATLPIPQQWCICQVDKFEIHNETLKNH-----LGEKLLNHVHRKLKKLNVSEICE 530

  Fly   549 NFTLDYVEKADRKTILSNGLRPADKNEQVYIIVFE-TVPKNPIFEATVRWNSRTQRLLHFDV--- 609
            .|.|..|     .:::..|.   .:..:.|.|..| |:.....||..|.::..|      |:
Worm   531 TFRLSKV-----TSLIEYGY---VRTMRTYKISVETTISSYAHFETFVTYDIET------DIAKF 581

  Fly   610 EELSRLTSYKNDANCINRKNAKKYCICKD 638
            |:::||.:|....:|.........|.||:
Worm   582 EKVTRLDNYAMTTDCTKPIRQSPLCYCKN 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10730	NP_610021.3	DUF229	55..556	CDD:281053	124/461 (27%)
CG10730	NP_610021.3	ALP_like	188..467	CDD:293745	87/306 (28%)
T07G12.3	NP_501945.2	DUF229	67..538	CDD:281053	125/466 (27%)
T07G12.3	NP_501945.2	ALP_like	161..448	CDD:293745	87/306 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010