DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10730 and F07C3.3

DIOPT Version :9

Sequence 1:	NP_610021.3	Gene:	CG10730 / 35291	FlyBaseID:	FBgn0032843	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_505391.4	Gene:	F07C3.3 / 184124	WormBaseID:	WBGene00017194	Length:	746	Species:	Caenorhabditis elegans

Alignment Length:	701	Identity:	177/701 - (25%)
Similarity:	273/701 - (38%)	Gaps:	171/701 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WIENLVQGADD-------------YYVYSPVCQMPAVNPFTWDTMSNFH---RKTLRHCH-NDSD 67
            |..| |.|.||             ::.:...|:.|..|.:..|.:. ||   |.....|. ...|
Worm    67 WNIN-VFGDDDNIKTEIERDPLLTHHPFDNTCKFPLPNSYAEDIIP-FHLSERMRQLKCEVKQKD 129

  Fly    68 MVTSEFDFETHQYRLHVHEHLAK-PIMNRKGNATLECEYQEISRDNSDQKPDNAYNQLRRR---- 127
            ..|  .|.|.:   ::||.|... |.:.|    .::|:...|  :...:||:.  |..:..
Worm   130 YAT--MDSEGY---IYVHPHFVDWPRLER----DVQCKVDII--EGGLRKPER--NMTKNSMFIK 181

  Fly   128 -----PIEQHQFVPNNTDYMITSCYVRDVTKHRELLQQDAISFIEDRLPKEKVKDFVKDE----- 182
                 |..:..||  |.|..:.:||     .|.:...:..:...:...|..|.|:..:||
Worm   182 KTLEIPSNERLFV--NADAFVINCY-----NHSKKAVKPEVPIWKKPFPGMKDKNLPEDEILRVK 239

  Fly   183 -----------------SEVHKPSVLIMGLDSTSRINLRRAMPSVYKFVRQPGWFEMQGYNKVGD 230
                             ..|.:.|:.|:|.|||:|....|.||...:.:.:..:..:.||.||.|
Worm   240 DLYSYGDYGNKIREQVSKAVDRYSIDILGFDSTARTMFMRHMPRTVEVMAKLDYHYLYGYTKVAD 304

  Fly   231 NTFPNLLAALTGDSEKGV--------GDY-----------CDVTKPGCLDSLNFIWKRFK-KANY 275
            |:..||...|.||.|:.:        ||:           .|.||      |||:||..| |...
Worm   305 NSMVNLAPILVGDMEEALKKPKYDKSGDFNINWLLPTEDKMDPTK------LNFLWKIMKEKYGC 363

  Fly   276 TTAFAEDCSS--ISTFNY----LKPGFVKQPTDYYLRPLLFAIEKQFKVTNDFGFAYC-VGRHL- 332
            .:.|.||.|:  :..|||    .:|||.:.|.|:|.|....|:.:.:|      :..| .|..|
Worm   364 ESLFNEDISTKGLGLFNYPPTEFQPGFTENPADHYYRAYYLAVYENWK------YEACRDGEQLQ 422

  Fly   333 -SFSYVWDFGQQFIDRFLGRSPMFGFLWSNSFTHDYYEGATALDNLLWKYLKSFEESNLFQKSIV 396
             .|..:|   ::|..|:.... .|||.:..:.||:.......||..|..:|.....:.....::.
Worm   423 NEFVNIW---RRFAHRYRNIC-HFGFTFVTTLTHEAGLVLEILDEKLAAHLSQMHLNGDLDNTLS 483

  Fly   397 ILMSDHGHRYNTLRRASTGYFEERMPMMFIYLPPWFRRKYPHLASNLGKNQNRLSSNYDVYMTLQ 461
            |:|.|||:|...::...||..|||||:|.:..|..|...||....|...|:::|:||:||:.||.
Worm   484 IIMGDHGNRIGAIKSRYTGRIEERMPLMAMRFPTGFAETYPVEYKNFLDNKHKLTSNFDVHKTLH 548

  Fly   462 HLLQLDSKSVDEFPDNLRARQCKSCQ----SLFFELPFNRTCQMAGIEEKWCCCQPTETITNSPH 522
            .::.:      ...||    :.||.:    |||..:|..|||....:.|.:|.|.        ..
Worm   549 DIVHM------RLGDN----KAKSDEGRGISLFDAIPNTRTCADVIVPENFCMCM--------ID 595

  Fly   523 VSTIAEAIV---------QRMNEH------LISHNLSDLCHNFTLDYVEKADRKTI--LSN-GLR 569
            ||:||..:.         |:|::.      |.:.||.|.....:|:..:......|  ||. |||
Worm   596 VSSIANPLPNFNKKKPTDQKMDQFNTLKSWLKTENLDDCVDVSSLETGQTFQEMAINPLSRFGLR 660

  Fly   570 PADKNEQVYIIVFETVPKNPIFEATVRWNSRTQRLLHFDVEELSRLTSYKN 620
             ...|..:..::.|...|||              .|::...|.|...:|||
Worm   661 -TKNNASMLELMKERNKKNP--------------ELNYINFEFSVSGTYKN 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10730	NP_610021.3	DUF229	55..556	CDD:281053	149/584 (26%)
CG10730	NP_610021.3	ALP_like	188..467	CDD:293745	93/307 (30%)
F07C3.3	NP_505391.4	DUF229	75..623	CDD:308570	151/602 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165302
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840