DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10730 and R03G8.3

DIOPT Version :9

Sequence 1:	NP_610021.3	Gene:	CG10730 / 35291	FlyBaseID:	FBgn0032843	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_510174.3	Gene:	R03G8.3 / 181437	WormBaseID:	WBGene00010998	Length:	654	Species:	Caenorhabditis elegans

Alignment Length:	706	Identity:	152/706 - (21%)
Similarity:	265/706 - (37%)	Gaps:	136/706 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSRKDF---QALLIVICF-------GFWIENLVQGADDYY-VYSPV------------------- 37
            ||:.::   :|||:..||       ||.:.:.:.....|. :|.|:
Worm     5 LSKMEYVPWKALLVTGCFAMYLVLLGFTMFSPLLSPQQYLGLYQPISGNIPSKVVMNKSEVEPWD 69

  Fly    38 -CQMPAVNPFTWD----TMSNFHRKTLRHCHNDSDMVTSEFDFETHQYRLHVHEHLAKPIMNRKG 97
             |::|..:  .||    ...|.....:.:|:...:.:|                     .:|...
Worm    70 QCELPQYD--IWDDEILPYLNMEVNPISNCNKSREPLT---------------------FLNNGS 111

  Fly    98 NATLECEYQEISRDNSDQKPDNAYNQLRRRPIEQHQFVPNNTDYMITSCYVRDVTKHRELLQQDA 162
            ...:..:.:.|.|.....:....||     .|....:.|...:..:......|..|       |.
Worm   112 WGVVNKKTKLICRARCHTRKSERYN-----VIGNWTYTPGPINCEVVEAVCADGKK-------DV 164

  Fly   163 ISFIEDRLPKEKVKDFVKDESEVHKPSVLIMGLDSTSRINLRRAMPSVYKFVRQPGWFEMQGY-N 226
            ..|:..::.....|......||:....|.::.|||.|....:|::.....::.......:..| |
Worm   165 YGFLHTQVIATPPKQPTVKVSELKNYDVTVIMLDSLSFTQAKRSLLRTISYMTNHMDAVLFPYIN 229

  Fly   227 KVGDNTFPNLLAALTGDS----------EKGVG-DY-----CDVTKPGCLDSLNFIWKRFKKANY 275
            |||||:.||..|...|.|          |:.|. |:     |.|.|    |:...::|.::...|
Worm   230 KVGDNSRPNGAALWFGKSLEKLDRSLFEEENVPVDWSHAYMCHVYK----DNETSLFKEYQNYGY 290

  Fly   276 TTAFAEDCSSISTFNYLK-PGFVKQPTDYYLRPLLFAIEK--------QFKVTNDFGFAYCVGRH 331
            .|..|||.:. .|.|:.. .||.|.|.|:.:||...|:|:        :..:.|.   .||...|
Worm   291 KTLMAEDWAE-GTLNWPNCKGFDKPPIDHLMRPFQNALERANHGEPLTKSHLKNQ---KYCREDH 351

  Fly   332 LSFSYVWDFGQQFIDRFLGRSPMFGFLWSNSFTHDYYEGATALDNLLWKYLKSFEESNLFQKSIV 396
            .:   :.|:..|||:.:..:: .|.::|::...||...|....|....|:|....|.  ...|.|
Worm   352 HT---LLDYLSQFINAYPDQN-KFRWIWASILGHDSENGFPHSDKDFHKFLIKHREQ--LDNSFV 410

  Fly   397 ILMSDHGHRYNTLRRASTGYFEERMPMMFIYLPPWFRRKYPHLASNLGKNQNRLSSNYDVYMTLQ 461
            ..|.|||.|:..:|:...|..:...|.:.:.:|...|:. ..|.:.:.:|..::.:::|...|:.
Worm   411 FFMGDHGLRFGNVRKTFVGTLDVSNPFLAVSIPKNLRQT-TGLLNVMRENAQKIQTHFDTRATML 474

  Fly   462 HLLQLDSKSVDEFPDNLRARQCKSCQSLFFELPFNRTCQMAGIEEKWCCCQ--PTETITNSPHVS 524
            .:|:..|.|.....|.|.....|....:..:....|.|:...|..::|.||  .|:..|.|....
Worm   475 DILKYQSASNFTDLDPLIIPGEKGYSYIRTQPDILRNCRNMPIPMQYCICQFNKTQVSTKSETAK 539

  Fly   525 TIAEAIVQRMNEHLISHNLSDLCHNFTLDYVE---KADRKTILSNGLRPADKNEQVYIIVFE-TV 585
            .:.||:...:|..:.....:|.|....:|:|.   :.|:|.          |...:|..|.| |.
Worm   540 GVGEAVALAVNNEIEEGKFTDKCVKMKVDHVVSLLQFDQKF----------KGSMLYTAVVEMTK 594

  Fly   586 PKNPIFEATVRWNSRTQRLLHFDVEEL---SRLTSYKNDANCINRKNAKKYCICKD 638
            |...:::|.|:      .|.:.:|:.|   .|...|.:.|.||..::.:.||.||:
Worm   595 PSKAVYKANVK------ILENGEVKVLGMVERSNKYGSTAYCIGSEHHRPYCYCKN 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10730	NP_610021.3	DUF229	55..556	CDD:281053	112/528 (21%)
CG10730	NP_610021.3	ALP_like	188..467	CDD:293745	76/304 (25%)
R03G8.3	NP_510174.3	DUF229	92..570	CDD:281053	112/525 (21%)
R03G8.3	NP_510174.3	ALP_like	190..480	CDD:293745	76/304 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28588
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950