DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vls and PFS2

DIOPT Version :9

Sequence 1:	NP_610019.2	Gene:	vls / 35289	FlyBaseID:	FBgn0003978	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_014082.1	Gene:	PFS2 / 855399	SGDID:	S000005261	Length:	465	Species:	Saccharomyces cerevisiae

Alignment Length:	232	Identity:	46/232 - (19%)
Similarity:	90/232 - (38%)	Gaps:	44/232 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 GRDQM-------HHMSVDSANFKLQAEHTVNIVRYA-EDDFLLVALGDTRLQAWSTYSKVRDSQS 140
            |||::       .|:|.:      :.:|.:..:::. |...|:||........|:..|...::.
Yeast    73 GRDRVINLPSKFTHLSSN------KVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETL- 130

  Fly   141 PYCLFLVGESSAHPTPISQLSVFKADPRTAVSGSADSTLNVWDLSGADMVSTYRSRSSHTDKLTG 205
                     ..||.:.::.:. :..|....:||.||..:.:|. ....||.  ...::||:.:..
Yeast   131 ---------MQAHDSAVTTMK-YSHDSDWMISGDADGMIKIWQ-PNFSMVK--EIDAAHTESIRD 182

  Fly   206 LATPAASVDKFVTCDRGGCARLWDVRAAAPSSTCLYADASHVLSFTSAAW-------AAASELQG 263
            :|. :::..|||||......::|:..........    :.|.....|..|       |:||:
Yeast   183 MAF-SSNDSKFVTCSDDNILKIWNFSNGKQERVL----SGHHWDVKSCDWHPEMGLIASASK--- 239

  Fly   264 DNHIYLGD-YDGKVHTLDIRVPRKLAETREYFDKGHV 299
            ||.:.|.| ..|...:..::....:.:||....||::
Yeast   240 DNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNL 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vls	NP_610019.2	WD40	106..>282	CDD:295369	36/184 (20%)
		WD40	<134..>358	CDD:225201	34/174 (20%)
		WD40 repeat	157..198	CDD:293791	8/40 (20%)
		WD40 repeat	204..245	CDD:293791	7/40 (18%)
		WD40 repeat	250..281	CDD:293791	10/38 (26%)
		WD40 repeat	289..335	CDD:293791	4/11 (36%)
PFS2	NP_014082.1	WD40	93..377	CDD:238121	41/206 (20%)
		WD40 repeat	98..133	CDD:293791	6/44 (14%)
		WD40 repeat	139..175	CDD:293791	8/39 (21%)
		WD40 repeat	180..216	CDD:293791	7/40 (18%)
		WD40 repeat	223..257	CDD:293791	10/36 (28%)
		WD40 repeat	264..299	CDD:293791	4/13 (31%)
		WD40 repeat	307..346	CDD:293791
		WD40 repeat	353..377	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0284
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810