DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vls and Wdr77

DIOPT Version :9

Sequence 1:	NP_610019.2	Gene:	vls / 35289	FlyBaseID:	FBgn0003978	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_081708.1	Gene:	Wdr77 / 70465	MGIID:	1917715	Length:	342	Species:	Mus musculus

Alignment Length:	364	Identity:	84/364 - (23%)
Similarity:	142/364 - (39%)	Gaps:	57/364 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PPPALELAGNLEYPNLNIADLNARLENLSPRLHDCW----DSIAINDHNHLALATNRREGRQWWG 78
            |||.:..|              ||..||.|....|.    ::........|.|..:...||.|.|
Mouse     6 PPPLVPPA--------------AREWNLPPNAPACMERQLEAARYRSDGSLLLGVSSLSGRCWVG 56

  Fly    79 MLFGYGRDQMHHMSVDSANFKLQAEHTVNIVRYAEDDFLLVALGDTRLQAWSTYSKVRDSQSPYC 143
            .|: :.:|.....:....:..:|.|..|..:.:..|..:|||.....::.|..........|.:|
Mouse    57 SLW-FFKDPSAAPNEGFCSAGVQTEAGVADLTWVGDKGILVASDSGAVELWELDENETLIVSKFC 120

  Fly   144 LFLVGESSAHPTPISQLSVFKADPRTAVSGSADSTLNVWDLSGADMVSTYRSRSSHTDKLTGLAT 208
            .:      .|...:|.::|..:..: |||||.|..:.:|||:....:::||   :|..::|.:|.
Mouse   121 KY------EHDDIVSTVTVLSSGTQ-AVSGSKDCCIKIWDLAQQVSLNSYR---AHAGQVTCVAA 175

  Fly   209 PAASVDKFVTCDRGGCARLWDVRAAAPSSTCLYADASHVLSFTSAAWAAASELQGDNHIYLGDYD 273
            .......|::|.......|||.|...|:|. :..:||..|. |:.||    ..|.......||.:
Mouse   176 SPHKDSVFLSCSEDSRILLWDTRCPKPASQ-MACNASGYLP-TALAW----HPQQSEVFVFGDEN 234

  Fly   274 GKVHTLDIR--------VPRKLAETREYFDKGHVAQLLINGPHLAAMSNLPASV-KVANVQAGHE 329
            |.|..:|.:        .......||..|.. |...||.:.....:::.|.:|: :|...:|..:
Mouse   235 GSVSLVDTKNASCTLSSAVHSQGVTRLVFSP-HSVPLLTSLSEDCSLAVLDSSLSEVFRSRAHRD 298

  Fly   330 FIYTHQDTHSRLTDAVWT--DDSTLITIGHGRKMVTHAI 366
            |:          .||.|:  :.|.|.|:|...:::.|.:
Mouse   299 FV----------RDATWSPLNHSLLTTVGWDHQVIHHVV 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vls	NP_610019.2	WD40	106..>282	CDD:295369	45/175 (26%)
		WD40	<134..>358	CDD:225201	57/234 (24%)
		WD40 repeat	157..198	CDD:293791	13/40 (33%)
		WD40 repeat	204..245	CDD:293791	10/40 (25%)
		WD40 repeat	250..281	CDD:293791	8/30 (27%)
		WD40 repeat	289..335	CDD:293791	11/46 (24%)
Wdr77	NP_081708.1	WD 1	22..75		9/53 (17%)
		WD 2	78..116		8/37 (22%)
		WD40	80..319	CDD:295369	64/265 (24%)
		WD40 repeat	83..120	CDD:293791	7/36 (19%)
		WD40	<98..>322	CDD:225201	58/250 (23%)
		WD 3	123..162		12/39 (31%)
		WD40 repeat	129..164	CDD:293791	11/35 (31%)
		WD 4	165..205		10/39 (26%)
		WD40 repeat	170..207	CDD:293791	10/37 (27%)
		WD 5	209..250		12/45 (27%)
		WD40 repeat	215..256	CDD:293791	9/45 (20%)
		WD 6	253..293		9/40 (23%)
		WD40 repeat	258..282	CDD:293791	6/24 (25%)
		WD 7	295..330		10/43 (23%)
		WD40 repeat	300..333	CDD:293791	8/38 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0284
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50221
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007197
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108117
Panther	1	1.100	-	-	LDO	PTHR46853
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780