DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vls and wdr33

DIOPT Version :9

Sequence 1:	NP_610019.2	Gene:	vls / 35289	FlyBaseID:	FBgn0003978	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001181857.1	Gene:	wdr33 / 449009	ZFINID:	ZDB-GENE-040924-3	Length:	1102	Species:	Danio rerio

Alignment Length:	255	Identity:	57/255 - (22%)
Similarity:	87/255 - (34%)	Gaps:	82/255 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 EGRQ------------WWGMLFGYGRDQMHHMSVDSANFK--LQA-EHTVNIVRYAEDD-FLLVA 120
            |||:            |.|:.|               ||:  ||| :..|..:.::.:| ::|.|
Zfish   130 EGRRLVTGASSGEFTLWNGLTF---------------NFETILQAHDSPVRAMTWSHNDMWMLTA 179

  Fly   121 LGDTRLQAW-STYSKVRDSQSPYCLFLVGESSAHPTPISQLSVFKADPRTAVSGSADSTLNVWDL 184
            .....::.| |..:.|:..|            ||...|.:.|....|.:.|.. |.|.|:.:||.
Zfish   180 DHGGYVKYWQSNMNNVKMFQ------------AHKEAIREASFSPTDNKFATC-SDDGTVRIWDF 231

  Fly   185 -----------SGADMVSTYRSRSSHTDKLTGLATPAASVDKFVTCDRGGCARLWDVRAAAPSST 238
                       .|||:    :....|..|  ||....:.       |.....:.||.:.....:|
Zfish   232 LRCHEERILRGHGADV----KCVDWHPTK--GLVVSGSK-------DSQQPIKFWDPKTGQSLAT 283

  Fly   239 CLYADASHVLSFTSAAWAAASELQGDNHIYLGDYDGKVHTLDIRVPRKLAETREYFDKGH 298
             |:|..:.|:   ...|    .|.| |.:.....|......||   |.|.|..:.| :||
Zfish   284 -LHAHKNTVM---EVKW----NLNG-NWLLTASRDHLCKLFDI---RNLKEELQVF-RGH 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vls	NP_610019.2	WD40	106..>282	CDD:295369	39/188 (21%)
		WD40	<134..>358	CDD:225201	40/176 (23%)
		WD40 repeat	157..198	CDD:293791	12/51 (24%)
		WD40 repeat	204..245	CDD:293791	8/40 (20%)
		WD40 repeat	250..281	CDD:293791	5/30 (17%)
		WD40 repeat	289..335	CDD:293791	4/10 (40%)
wdr33	NP_001181857.1	WD40	121..>405	CDD:225201	57/255 (22%)
		WD40	121..402	CDD:238121	57/255 (22%)
		WD40 repeat	122..159	CDD:293791	9/43 (21%)
		WD40 repeat	165..200	CDD:293791	7/46 (15%)
		WD40 repeat	205..241	CDD:293791	9/36 (25%)
		WD40 repeat	248..285	CDD:293791	8/46 (17%)
		WD40 repeat	291..328	CDD:293791	12/48 (25%)
		WD40 repeat	336..371	CDD:293791
		WD40 repeat	378..402	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0284
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900