DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vls and Wdr33

DIOPT Version :9

Sequence 1:	NP_610019.2	Gene:	vls / 35289	FlyBaseID:	FBgn0003978	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_730982.1	Gene:	Wdr33 / 40698	FlyBaseID:	FBgn0046222	Length:	807	Species:	Drosophila melanogaster

Alignment Length:	338	Identity:	72/338 - (21%)
Similarity:	115/338 - (34%)	Gaps:	128/338 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ATNRR-----------EGRQ------------WWGMLFGYGRDQMHHMSVDSANFK--LQAEHTV 106
            |||:.           |||:            |.|:.|               ||:  ||| |.:
  Fly   141 ATNKMRCPIFTLAWTPEGRRLVTGASSGEFTLWNGLTF---------------NFETILQA-HDI 189

  Fly   107 NI--VRYAEDDFLLVALGD--TRLQAW-STYSKVRDSQSPYCLFLVGESSAHPTPISQLSVFKAD 166
            ::  :.::.:|..:|. ||  ..::.| |..:.|:..|            ||...|..:|....|
  Fly   190 SVRTMVWSHNDSWMVT-GDHGGYVKYWQSNMNNVKMYQ------------AHKEAIRGISFSPTD 241

  Fly   167 PRTAVSGSADSTLNVWDL-----------SGADMVSTYRSRSSHTDKLTGLATPAASVDKFVTCD 220
            .: .||||.|.||.:||.           .|||:      :..|.....|:....:.       |
  Fly   242 SK-FVSGSDDGTLRIWDFMRCQEERVLRGHGADV------KCVHWHPQKGMIVSGSK-------D 292

  Fly   221 RGGCARLWDVRAAAPSSTCLYADASHVLSFTSAAWAAASELQGDNHIYL--GDYDGKVHTLDIRV 283
            .....::||.::....:| |:|..|.|:..   .|       .||..:|  ...|..:...||
  Fly   293 NQQPIKIWDPKSGIALAT-LHAHKSTVMDL---KW-------NDNGNWLVTASRDHLLKLFDI-- 344

  Fly   284 PRKLAETREYFDKGHVAQ------------LLINGPHLAAMS--NLPASVKVANVQAGHEFIYTH 334
             |.|.|..:.| :||..:            |..:|....::.  |:....::..|:..|:.|
  Fly   345 -RNLREEVQVF-RGHKKEASSVSWHPIHEGLFCSGGSDGSILFWNVGTDKEIGCVETAHDSI--- 404

  Fly   335 QDTHSRLTDAVWT 347
                      |||
  Fly   405 ----------VWT 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vls	NP_610019.2	WD40	106..>282	CDD:295369	41/193 (21%)
		WD40	<134..>358	CDD:225201	51/241 (21%)
		WD40 repeat	157..198	CDD:293791	15/51 (29%)
		WD40 repeat	204..245	CDD:293791	7/40 (18%)
		WD40 repeat	250..281	CDD:293791	5/32 (16%)
		WD40 repeat	289..335	CDD:293791	10/59 (17%)
Wdr33	NP_730982.1	WD40	146..429	CDD:238121	69/333 (21%)
		WD40	148..>432	CDD:225201	69/331 (21%)
		WD40 repeat	149..186	CDD:293791	9/51 (18%)
		WD40 repeat	192..227	CDD:293791	8/47 (17%)
		WD40 repeat	232..268	CDD:293791	12/36 (33%)
		WD40 repeat	275..312	CDD:293791	6/44 (14%)
		WD40 repeat	318..355	CDD:293791	12/50 (24%)
		WD40 repeat	362..398	CDD:293791	3/35 (9%)
		WD40 repeat	405..429	CDD:293791	3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0284
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810