DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vls and wdr77

DIOPT Version :9

Sequence 1:	NP_610019.2	Gene:	vls / 35289	FlyBaseID:	FBgn0003978	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001120009.1	Gene:	wdr77 / 100144971	XenbaseID:	XB-GENE-972898	Length:	333	Species:	Xenopus tropicalis

Alignment Length:	315	Identity:	77/315 - (24%)
Similarity:	134/315 - (42%)	Gaps:	45/315 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 LALATNRREGRQWWGMLFGY-GRDQMHHMSVDSANFKLQAEHTVNIVRYAEDDFLLVALGDTRLQ 127
            |.||.:....|.|.|.::.: ..|...:.|:.:|.  :|.|..|..|.:..:..:|||.....::
Frog    32 LLLAASSLSSRTWGGSIWVFKDPDSAPNESLCTAG--VQTEAGVTDVAWVSEKGILVASDSGAVE 94

  Fly   128 AWSTYSKVRDSQSPYCLFLVGESS--AHPTPISQLSVFKADPRTAVSGSADSTLNVWDLSGADMV 190
            .|    ::.:.:|    .||.:.:  .|...:..|||| :|...||||..|.::.||||:...::
Frog    95 LW----EILEKES----LLVNKFTKYEHDDIVKSLSVF-SDGTQAVSGGKDFSVKVWDLTQKTLL 150

  Fly   191 STYRSRSSHTDKLTGLATPAASVDKFVTCDRGGCARLWDVRAAAPSSTCLYADASHVLSFTSAAW 255
            ::|.:.||..:.:.  |.|.... .|::|...|...|||.|...|::...:.....:.  ||..|
Frog   151 NSYIAHSSEVNCVA--ACPGKEA-IFLSCGEDGKILLWDTRKPKPATRIDFFTPDTIP--TSVTW 210

  Fly   256 AAASELQGDNHIYLGDYDGKVHTLDIRVPRKLAETREYFDKGHVAQLLING--------PHLAAM 312
                ..:.|:....||..|.|:.::::       ..:...|..|....|.|        |:||::
Frog   211 ----HPEKDDTFACGDEIGNVYLVNLK-------NLDSVQKSSVHSQSITGLAYSYHSSPYLASI 264

  Fly   313 SNLPASVKVANVQAGHEF-IYTHQDTHSRLTDAVWT--DDSTLITIGHGRKMVTH 364
            |. ..:|.|.:......| ..:|:|.   :|...|:  |.|...|:|...|::.|
Frog   265 SE-DCTVAVYDSDFSEAFRDLSHRDF---VTGVAWSPLDHSKFTTVGWDHKVLHH 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vls	NP_610019.2	WD40	106..>282	CDD:295369	45/177 (25%)
		WD40	<134..>358	CDD:225201	58/236 (25%)
		WD40 repeat	157..198	CDD:293791	15/40 (38%)
		WD40 repeat	204..245	CDD:293791	10/40 (25%)
		WD40 repeat	250..281	CDD:293791	8/30 (27%)
		WD40 repeat	289..335	CDD:293791	11/54 (20%)
wdr77	NP_001120009.1	WD40	<43..312	CDD:225201	71/299 (24%)
		WD40	70..>297	CDD:295369	61/255 (24%)
		WD40 repeat	73..110	CDD:293791	9/44 (20%)
		WD40 repeat	119..154	CDD:293791	14/35 (40%)
		WD40 repeat	160..197	CDD:293791	10/39 (26%)
		WD40 repeat	205..242	CDD:293791	9/49 (18%)
		WD40 repeat	248..273	CDD:293791	7/25 (28%)
		WD40 repeat	290..312	CDD:293791	6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50221
OrthoDB	1	1.010	-	-		D337178at33208
OrthoFinder	1	1.000	-	-		FOG0007197
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46853
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030