DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and NEK9

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001316166.1	Gene:	NEK9 / 91754	HGNCID:	18591	Length:	991	Species:	Homo sapiens

Alignment Length:	336	Identity:	104/336 - (30%)
Similarity:	164/336 - (48%)	Gaps:	49/336 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 DLSPNESI--------GLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGA 213
            |.||..|.        |..|:....|...|.||.||:|...|.   |..:..::.:.|:..|
Human    27 DSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGEATLY---RRTEDDSLVVWKEVDL--- 85

  Fly   214 RPSTNFSDPDR--VLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRII--SNKL 274
               |..|:.:|  .|||..|:..|.|..::..::......::.:.||:..||:|.::|:  .:||
Human    86 ---TRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKL 147

  Fly   275 LSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKD-SVMR 338
            ..|::...|.:|:..||..:|..||.|||:|..|:.|   .:..|:|:.|:||:|.:..: |:..
Human   148 FEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFL---TKANLIKLGDYGLAKKLNSEYSMAE 209

  Fly   339 TLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYG 403
            ||.|||.|::|| |..|.:  |..|.|||::|.|:|..|  ||..:.:...|....:|   ...|
Human   210 TLVGTPYYMSPE-LCQGVK--YNFKSDIWAVGCVIFELL--TLKRTFDATNPLNLCVK---IVQG 266

  Fly   404 HPSWKSVSQRAKLLINQM----LIVDPERRPSIDDVLQSSWLRDAPMLQKAKRLMKLDGMEIEEE 464
            ..:.:..|.:..|.:.||    |..|||:||:.|::|      |.|:|:|.:|.|:      |:.
Human   267 IRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELL------DRPLLRKRRREME------EKV 319

  Fly   465 NFLEPPTKRSR 475
            ..|..||||.|
Human   320 TLLNAPTKRPR 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	86/282 (30%)
		S_TKc	174..441	CDD:214567	85/275 (31%)
NEK9	NP_001316166.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..43		4/15 (27%)
		STKc_Nek9	51..308	CDD:270860	87/282 (31%)
		S_TKc	52..308	CDD:214567	87/281 (31%)
		RCC1 1	388..444
		RCC1	389..441	CDD:278826
		RCC1	444..495	CDD:278826
		RCC1 2	445..498
		RCC1	500..559	CDD:278826
		RCC1 4	563..627
		RCC1 5	628..680
		RCC1	628..676	CDD:278826
		RCC1 6	681..738
		Interaction with NEK6. /evidence=ECO:0000269\|PubMed:19001501	744..903
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..795
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	833..853
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..991
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910