DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and PSKH2

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_016869418.1	Gene:	PSKH2 / 85481	HGNCID:	18997	Length:	504	Species:	Homo sapiens

Alignment Length:	272	Identity:	94/272 - (34%)
Similarity:	155/272 - (56%)	Gaps:	14/272 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 KTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLS 236
            :.|.:...:|:|::..|..|....|.:.||:|:::.....|.         :..::|..:::.:|
Human   180 RRYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGR---------EACVSELSVLRRVS 235

  Fly   237 HPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITH 301
            |..:|::.:|.:..|.||||:|...||:|.:|:|:....:|..:......:...::|||...|||
Human   236 HRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITH 300

  Fly   302 RDLKPDNVLLETNDEETLLKVSDFGLSKFVQK--DSVMRTLCGTPLYVAPEVLITGGREAYTKKV 364
            |:|||:|:|.....||:.:.::||||:...:|  |..|:||||||.|:|||||:   |:.||..|
Human   301 RNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLL---RKPYTSAV 362

  Fly   365 DIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERR 429
            |:|:|||:.:..|||.|||.||..|...::|.||::.|....|.|:|..||..|:::||::...|
Human   363 DMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHR 427

  Fly   430 PSIDDVLQSSWL 441
            .|....|...|:
Human   428 MSAGQALDHPWV 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	93/270 (34%)
		S_TKc	174..441	CDD:214567	93/268 (35%)
PSKH2	XP_016869418.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910