DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and DUN1

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_010182.1	Gene:	DUN1 / 851457	SGDID:	S000002259	Length:	513	Species:	Saccharomyces cerevisiae

Alignment Length:	475	Identity:	145/475 - (30%)
Similarity:	229/475 - (48%)	Gaps:	88/475 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 NNDEFTAGRGEANDLILTLNDLPEKILTRISKVHFIIKRANCELTNPVYIQDLSRNGTFVNNEKI 129
            |.:..|.||..:.|:||:..|    |.|..::.|.:....:....|.:.:.|.||||||:|..::
Yeast    52 NRNVTTIGRSRSCDVILSEPD----ISTFHAEFHLLQMDVDNFQRNLINVIDKSRNGTFINGNRL 112

  Fly   130 GTNRMRILKNDDVISLSHPTYKAFVFKDLS----------------------PNESIGLPE---- 168
             ..:..||||.|.|......  :|:||..|                      .:|....|:
Yeast   113 -VKKDYILKNGDRIVFGKSC--SFLFKYASSSSTDIENDDEKVSSESRSYKNDDEVFKKPQISAT 174

  Fly   169 ------------EINKT--------YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGA 213
                        ::|||        |.:.::||:|.|.||:...:.:|.||.|:||.........
Yeast   175 SSQNATTSAAIRKLNKTRPVSFFDKYLLGKELGAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQ 239

  Fly   214 RPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDS-----VYMVLEFMRGGDLLNRIISNK 273
            :.:..|.:      |..|:..:.||.:|.:.|...:|.|     .|:|||.:..|:|..||:...
Yeast   240 KKNKQFRE------ETNILMRVQHPNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKT 298

  Fly   274 LLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETN-------------DEETL---LKV 322
            .|.:|.||..|.|:...:||||::.|.|||:||:|:||...             ||:.:   :|:
Yeast   299 CLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKI 363

  Fly   323 SDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEY 387
            :||||:||..:.....||||||.|||||||.   ::.||.|||:||.||:|:.||.|..||||:.
Yeast   364 ADFGLAKFTGEMQFTNTLCGTPSYVAPEVLT---KKGYTSKVDLWSAGVILYVCLCGFPPFSDQL 425

  Fly   388 GTPA-AQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRDAPMLQKAK 451
            |.|: .:||.:.::|:..|.|..:......||:.:|:::|:.|.:||:.|...|..|  :.|::.
Yeast   426 GPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNLLVLNPDERYNIDEALNHPWFND--IQQQSS 488

  Fly   452 RLMKLDGMEIEEENFLEPPT 471
            ..::|..::|.:...  |.|
Yeast   489 VSLELQRLQITDNKI--PKT 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	27/90 (30%)
		STKc_Chk2	167..441	CDD:270986	107/319 (34%)
		S_TKc	174..441	CDD:214567	103/288 (36%)
DUN1	NP_010182.1	FHA	36..136	CDD:238017	27/90 (30%)
DUN1	NP_010182.1	STKc_CAMK	199..479	CDD:270687	103/288 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344881
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0615
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	198	1.000	Inparanoid score	I865
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002433
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101842
Panther	1	1.100	-	-	LDO	PTHR44167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1619
TreeFam	0	0.000	Not matched by this tool.
	8	7.790