DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment lok and ER

DIOPT Version :9

Sequence 1:NP_477219.1 Gene:lok / 35288 FlyBaseID:FBgn0019686 Length:476 Species:Drosophila melanogaster
Sequence 2:NP_180201.1 Gene:ER / 817173 AraportID:AT2G26330 Length:976 Species:Arabidopsis thaliana


Alignment Length:470 Identity:95/470 - (20%)
Similarity:172/470 - (36%) Gaps:87/470 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 ESQPMEKIVWGRLYGKNI--KIKSLGTSSKYRII-YTHSSFSVDL---NN------DEFTAGRGE 75
            |...::.|:..||...|:  .:.||.......:: .:|::...|:   ||      |.|....|.
plant   494 ELNQLQNIILLRLENNNLTGNVGSLANCLSLTVLNVSHNNLVGDIPKNNNFSRFSPDSFIGNPGL 558

  Fly    76 AND-LILTLNDLPEKILTRISK------------VHFIIKRANCELTNPVYIQDLSRNGTFVNNE 127
            ... |....:|....:...||:            :..::..|.|...||....|    |:.....
plant   559 CGSWLNSPCHDSRRTVRVSISRAAILGIAIGGLVILLMVLIAACRPHNPPPFLD----GSLDKPV 619

  Fly   128 KIGTNRMRILKNDDVISLSHPTYKAFVFKDLSPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVY 192
            ...|.::.||         |......|::|:     :.:.|.:::.|.:.....|..|..|    
plant   620 TYSTPKLVIL---------HMNMALHVYEDI-----MRMTENLSEKYIIGHGASSTVYKCV---- 666

  Fly   193 DTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVL 257
             .:.|:..|:|.:.         |.|.....:...|.:::.::.|..:|.:...........:..
plant   667 -LKNCKPVAIKRLY---------SHNPQSMKQFETELEMLSSIKHRNLVSLQAYSLSHLGSLLFY 721

  Fly   258 EFMRGG---DLLNRIISNKLLSEDISKLYFYQMCHAVKYLH---DRGITHRDLKPDNVLLETNDE 316
            :::..|   |||:.....|.|..|......|.....:.|||   ...|.|||:|..|:||   |:
plant   722 DYLENGSLWDLLHGPTKKKTLDWDTRLKIAYGAAQGLAYLHHDCSPRIIHRDVKSSNILL---DK 783

  Fly   317 ETLLKVSDFGLSK--FVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSG 379
            :...:::|||::|  .|.|......:.||..|:.||...|   ...|:|.|::|.|:||...|:.
plant   784 DLEARLTDFGIAKSLCVSKSHTSTYVMGTIGYIDPEYART---SRLTEKSDVYSYGIVLLELLTR 845

  Fly   380 TLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLL-----INQMLIVDPERRPSIDDVLQSS 439
            .....||.........|.|.......:...::...|.|     :.|:.::..:|:|:        
plant   846 RKAVDDESNLHHLIMSKTGNNEVMEMADPDITSTCKDLGVVKKVFQLALLCTKRQPN-------- 902

  Fly   440 WLRDAPMLQKAKRLM 454
               |.|.:.:..|::
plant   903 ---DRPTMHQVTRVL 914

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lokNP_477219.1 FHA 39..156 CDD:238017 25/141 (18%)
STKc_Chk2 167..441 CDD:270986 62/286 (22%)
S_TKc 174..441 CDD:214567 61/279 (22%)
ERNP_180201.1 PLN00113 7..916 CDD:215061 95/470 (20%)
leucine-rich repeat 73..93 CDD:275380
leucine-rich repeat 94..117 CDD:275380
leucine-rich repeat 118..141 CDD:275380
leucine-rich repeat 142..165 CDD:275380
leucine-rich repeat 166..213 CDD:275380
leucine-rich repeat 214..237 CDD:275380
leucine-rich repeat 239..260 CDD:275380
leucine-rich repeat 261..284 CDD:275380
leucine-rich repeat 285..308 CDD:275380
leucine-rich repeat 309..332 CDD:275380
leucine-rich repeat 333..356 CDD:275380
leucine-rich repeat 357..380 CDD:275380
leucine-rich repeat 381..404 CDD:275380
leucine-rich repeat 405..428 CDD:275380
leucine-rich repeat 429..452 CDD:275380
leucine-rich repeat 453..474 CDD:275380
leucine-rich repeat 477..498 CDD:275380 1/3 (33%)
leucine-rich repeat 501..523 CDD:275380 6/21 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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