DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Gak

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_112292.1	Gene:	Gak / 81659	RGDID:	621589	Length:	1305	Species:	Rattus norvegicus

Alignment Length:	298	Identity:	80/298 - (26%)
Similarity:	129/298 - (43%)	Gaps:	64/298 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 VNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDR-VLNEAKIMKNLS-HP 238
            |.|.|..|.:..|....|..:.:::|:|          |..:|..:.:| ::.|...:|.|| ||
  Rat    42 VRRVLAEGGFAFVYEAQDLGSGREYALK----------RLLSNEEEKNRAIIQEVCFLKKLSGHP 96

  Fly   239 CVVRM-------HDIVDKPDSVYMVLEFMRGGDL---LNRIISNKLLSEDISKLYFYQMCHAVKY 293
            .:|:.       .:..|...:.:::|..:..|.|   |.|:.....||.|.....|||.|.||::
  Rat    97 NIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLRRVECKGPLSCDSILKIFYQTCRAVQH 161

  Fly   294 LHDR--GITHRDLKPDNVLLETNDEETLLKVSDFGLSKFV----------QKDSVMR---TLCGT 343
            :|.:  .|.|||||.:|:||   ..:..:|:.|||.:..:          ||.:::.   |...|
  Rat   162 MHRQKPPIIHRDLKVENLLL---SNQGTIKLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNTT 223

  Fly   344 PLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSD---------EYGTPAAQQIKKGR 399
            |:|..||::.........:|.|||:||.:|:.......||.|         :|..|    :...|
  Rat   224 PMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIP----VNDTR 284

  Fly   400 FAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQ 437
            :...|.           ||..||.|:||.|.||.:|::
  Rat   285 YTVFHD-----------LIRGMLKVNPEERLSIAEVVR 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	80/298 (27%)
		S_TKc	174..441	CDD:214567	80/298 (27%)
Gak	NP_112292.1	STKc_GAK	39..320	CDD:270938	80/298 (27%)
		S_TKc	41..311	CDD:214567	80/296 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..354
		PTEN_C2	568..706	CDD:287393
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	747..856
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1141
		DnaJ	<1253..1298	CDD:99751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910