DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and nek11

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001072436.1	Gene:	nek11 / 779890	XenbaseID:	XB-GENE-955651	Length:	601	Species:	Xenopus tropicalis

Alignment Length:	304	Identity:	92/304 - (30%)
Similarity:	153/304 - (50%)	Gaps:	30/304 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 INKTYYVNRKLGSGAYGLVRLVYDTRT-CQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMK 233
            |.|.|.:.::||.|::|.|.||.|.:. .:|.::|::|:..:....|    ::..:...||:::.
Frog    24 IAKRYLLQQRLGKGSFGTVYLVIDKKAKDEQESLKVLKEIPVGELNP----NETVQANVEAQLLS 84

  Fly   234 NLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISK----LYFYQMCHAVKYL 294
            .|.||.:|:.|....:.:|..::.|:..|.||..::...|...|.|::    .:|.|:...|.|:
Frog    85 KLDHPAIVKFHASFLENESFCIITEYCEGRDLDFKVRECKKNEEKIAENQVVEWFIQLLLGVNYM 149

  Fly   295 HDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKD-SVMRTLCGTPLYVAPEVLITGGRE 358
            |.|.|.|||||..|:.|:.|    |||:.|||:|:.:... .:..|..|||.|::||.|   ..:
Frog   150 HVRRILHRDLKAKNIFLKNN----LLKIGDFGVSRLLMGSCDLATTFTGTPYYMSPEAL---KHQ 207

  Fly   359 AYTKKVDIWSLGVVL--FTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKS-VSQRAKLLINQ 420
            .|..|.||||||.:|  ..||...  |...........|.:|.    .||... .|....|::|:
Frog   208 GYDSKSDIWSLGCILHEMCCLEHA--FIGYNFLSVVISIVEGE----TPSLPDCYSSSLNLIMNR 266

  Fly   421 MLIVDPERRPSIDDVLQSSWLRDAPMLQKAKRLMKLDGMEIEEE 464
            ||..||..|||..::||..::.:  .|::.|  .::.|.|::::
Frog   267 MLNKDPALRPSAGEILQDPFINE--QLKQVK--WEVYGAEVKDK 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	88/279 (32%)
		S_TKc	174..441	CDD:214567	86/275 (31%)
nek11	NP_001072436.1	STKc_Nek11	27..287	CDD:270861	86/276 (31%)
nek11	NP_001072436.1	S_TKc	28..287	CDD:214567	86/275 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910