DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Prkd3

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001164475.1	Gene:	Prkd3 / 75292	MGIID:	1922542	Length:	890	Species:	Mus musculus

Alignment Length:	297	Identity:	99/297 - (33%)
Similarity:	167/297 - (56%)	Gaps:	22/297 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 KDLSPNESIGLPE-----EINKTY--YVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGA 213
            |||:.:.|:...:     :|:..|  :.:..||||.:|:|......:|.:..|:|::.|......
Mouse   551 KDLATSISVSNCQVQENVDISSVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTK 615

  Fly   214 RPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNK--LLS 276
            :.|       ::.||..|::||.||.:|.:..:.:.|:.|::|:|.:. ||:|..|:|::  .|.
Mouse   616 QES-------QLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLH-GDMLEMILSSEKSRLP 672

  Fly   277 EDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLC 341
            |.|:|....|:..|::.||.:.|.|.||||:||||.:.:....:|:.|||.::.:.:.|..|::.
Mouse   673 ERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVV 737

  Fly   342 GTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPS 406
            |||.|:|||||.:.|   |.:.:|:||:||:::..||||.||:::  .....||:...|.|....
Mouse   738 GTPAYLAPEVLRSKG---YNRSLDMWSVGVIVYVSLSGTFPFNED--EDINDQIQNAAFMYPPNP 797

  Fly   407 WKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRD 443
            |:.:|..|..|||.:|.|...:|.|:|..|...||:|
Mouse   798 WREISSEAIDLINNLLQVKMRKRYSVDKSLSHPWLQD 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	99/297 (33%)
		STKc_Chk2	167..441	CDD:270986	92/282 (33%)
		S_TKc	174..441	CDD:214567	91/270 (34%)
Prkd3	NP_001164475.1	C1_1	155..204	CDD:278556
		C1	272..321	CDD:237996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..370
		PH_PKD	410..534	CDD:269945
		PH	417..531	CDD:278594
		STKc_PKD	572..831	CDD:270984	91/271 (34%)
		S_TKc	580..832	CDD:214567	90/264 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910