DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Dclk2

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001344389.1	Gene:	Dclk2 / 70762	MGIID:	1918012	Length:	772	Species:	Mus musculus

Alignment Length:	297	Identity:	96/297 - (32%)
Similarity:	157/297 - (52%)	Gaps:	28/297 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 LSP--------NESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGAR 214
            |||        :||..|.|:    |.:.:.:|.|.:.:|:...|..|.::||:||:.|....|..
Mouse   389 LSPEGVNGNRCSESFPLLEK----YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGKE 449

  Fly   215 PSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDI 279
                    ..:.||..|::.:.||.::.:.:.::....:::|:|.::||||.:.|.|:...:|..
Mouse   450 --------HLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGGDLFDAITSSTKYTERD 506

  Fly   280 SKLYFYQMCHAVKYLHDRGITHRDLKPDNVLL-ETNDEETLLKVSDFGLSKFVQKDSVMRTLCGT 343
            .....|.:.:|::|||...|.|||:||:|:|: |..|....||:.||||:..|  :..:.|:|||
Mouse   507 GSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVV--EGPLYTVCGT 569

  Fly   344 PLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYG--TPAAQQIKKGRFAYGHPS 406
            |.|||||::...|   |..|||:|:.||:.:..|.|..||..|..  .....||..|:..:..|.
Mouse   570 PTYVAPEIIAETG---YGLKVDVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPY 631

  Fly   407 WKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRD 443
            |.:::..||.||:|||.|:.|.|.:..::|...|:.|
Mouse   632 WDNITDSAKELISQMLQVNVEARCTAGEILSHPWVSD 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	88/276 (32%)
		S_TKc	174..441	CDD:214567	87/269 (32%)
Dclk2	NP_001344389.1	DCX	67..157	CDD:214711
		DCX	191..279	CDD:214711
		PKc_like	407..665	CDD:328722	88/274 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910