DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and STK4

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_005260587.1	Gene:	STK4 / 6789	HGNCID:	11408	Length:	503	Species:	Homo sapiens

Alignment Length:	346	Identity:	94/346 - (27%)
Similarity:	153/346 - (44%)	Gaps:	36/346 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 TFVNNEKIGTNRMRILKNDDVISLSHPTYKAFVFKDLSPNESIGLPEEINKTYYVNRKLGSGAYG 186
            :|:.:.:...|.:.||     :|.|.|.. ....|.|..:.....|||:   :.|..|||.|:||
Human     3 SFITDVQCLPNGLHIL-----LSSSEPDI-GRQLKKLDEDSLTKQPEEV---FDVLEKLGEGSYG 58

  Fly   187 LVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPD 251
            .|.......|.|..|:|.|...           ||...::.|..||:....|.||:.:....|..
Human    59 SVYKAIHKETGQIVAIKQVPVE-----------SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNT 112

  Fly   252 SVYMVLEFMRGGDLLNRI-ISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETND 315
            .:::|:|:...|.:.:.| :.||.|:||............::|||.....|||:|..|:||.|
Human   113 DLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNT-- 175

  Fly   316 EETLLKVSDFGLSKFVQKDSVMR-TLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSG 379
             |...|::|||::..:......| |:.|||.::||||:...|   |....||||||:.......|
Human   176 -EGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG---YNCVADIWSLGITAIEMAEG 236

  Fly   380 TLPFSDEYGTPAAQQIKKGRFAYGHPSWKSV---SQRAKLLINQMLIVDPERRPSIDDVLQSSWL 441
            ..|::|.:...|...|...    ..|:::..   |......:.|.|:..||:|.:...:||..::
Human   237 KPPYADIHPMRAIFMIPTN----PPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV 297

  Fly   442 RDAPMLQKAKRLMKLDGMEIE 462
            |.|..:...:.|:. :.|:::
Human   298 RSAKGVSILRDLIN-EAMDVK 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	7/33 (21%)
		STKc_Chk2	167..441	CDD:270986	81/278 (29%)
		S_TKc	174..441	CDD:214567	78/271 (29%)
STK4	XP_005260587.1	STKc_MST1_2	42..297	CDD:132943	81/278 (29%)
		S_TKc	46..297	CDD:214567	78/271 (29%)
		Mst1_SARAH	449..496	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910