DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and RYK

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001005861.1	Gene:	RYK / 6259	HGNCID:	10481	Length:	610	Species:	Homo sapiens

Alignment Length:	358	Identity:	74/358 - (20%)
Similarity:	137/358 - (38%)	Gaps:	83/358 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 DLSRNGTFVNNEKIGTNRMRILKNDDVISLSHPTYKAFVFKDLS-PNESIGLPEEINKTYYVNRK 179
            |...|.|.:.: .:|...:||.|| |:.|::....|..| ||:: ..|.|.|.:.:.:..:
Human   287 DTPNNATPITS-SLGYPTLRIEKN-DLRSVTLLEAKGKV-KDIAISRERITLKDVLQEGTF---- 344

  Fly   180 LGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVR-- 242
             |...:|::....|....:|..:|.||..                 .:|.::...|:..|.:|
Human   345 -GRIFHGILIDEKDPNKEKQAFVKTVKDQ-----------------ASEIQVTMMLTESCKLRGL 391

  Fly   243 --------MHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLL---------SEDISKLYFYQMCHA 290
                    .|..:::.:...::|.:|..|:|...:...||:         .:|:..:.....| .
Human   392 HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIAC-G 455

  Fly   291 VKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSK--FVQKDSVMRTLCGTPL-YVAPEVL 352
            :.||..|.:.|:||...|.::   |:...:|::|..||:  |......:......|: ::|.|.|
Human   456 MSYLARREVIHKDLAARNCVI---DDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESL 517

  Fly   353 ITGGREAYTKKVDIWSLGVVLFTCLS-GTLPFSDEYGTPAAQQIKKG------------RFAYGH 404
            :   ...::...|:|:.||.|:..:: |..|:.|......|..:|.|            .||...
Human   518 V---NNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMA 579

  Fly   405 PSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQ 437
            ..|               .:|||.||....::|
Human   580 CCW---------------ALDPEERPKFQQLVQ 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	12/39 (31%)
		STKc_Chk2	167..441	CDD:270986	57/306 (19%)
		S_TKc	174..441	CDD:214567	57/299 (19%)
RYK	NP_001005861.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		WIF	63..196	CDD:128745
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..290		1/2 (50%)
		PTK_Ryk	326..606	CDD:270639	60/316 (19%)
		Pkinase_Tyr	333..599	CDD:285015	59/309 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910