DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and PSKH1

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_006733.1	Gene:	PSKH1 / 5681	HGNCID:	9529	Length:	424	Species:	Homo sapiens

Alignment Length:	275	Identity:	93/275 - (33%)
Similarity:	158/275 - (57%)	Gaps:	16/275 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 INKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVL-NEAKIMK 233
            :...|.:...:|.|::..|..|....|.|.:|:|:::          |.:.:...|. :|.::::
Human    94 VTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIE----------TKYREGREVCESELRVLR 148

  Fly   234 NLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRG 298
            .:.|..::::.::.:..:.||||:|...||:|.:|||:....:|..:......:...|:|||..|
Human   149 RVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALG 213

  Fly   299 ITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQK--DSVMRTLCGTPLYVAPEVLITGGREAYT 361
            ||||||||:|:|......::.:.::||||:...:|  |.:|:|.||||.|:|||||:   |:.||
Human   214 ITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV---RKPYT 275

  Fly   362 KKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDP 426
            ..||:|:|||:.:..||||:||.|:..|...:||.:|:::|....|.|||..||..|:::|.|||
Human   276 NSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDP 340

  Fly   427 ERRPSIDDVLQSSWL 441
            ..|.:....|:..|:
Human   341 GARMTALQALRHPWV 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	92/273 (34%)
		S_TKc	174..441	CDD:214567	92/269 (34%)
PSKH1	NP_006733.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..80
		STKc_PSKH1	96..355	CDD:270989	92/271 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..407
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2971
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940