DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and camk2b1

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_021331894.1	Gene:	camk2b1 / 562064	ZFINID:	ZDB-GENE-030131-9588	Length:	693	Species:	Danio rerio

Alignment Length:	269	Identity:	101/269 - (37%)
Similarity:	153/269 - (56%)	Gaps:	11/269 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHP 238
            |.:..:||.||:.:||......|.|::|.||:....|| ||      |..::..||:|.:.|.||
Zfish    13 YQLYEELGKGAFSVVRRCVKLSTGQEYAAKIINTKKLS-AR------DHQKLEREARICRLLKHP 70

  Fly   239 CVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRD 303
            .:||:||.:.:....|::.:.:.||:|...|::.:..||..:.....|:..||.:.|..|:.|||
Zfish    71 NIVRLHDSISEEGFHYLLFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRD 135

  Fly   304 LKPDNVLLETNDEETLLKVSDFGLSKFVQKD-SVMRTLCGTPLYVAPEVLITGGREAYTKKVDIW 367
            |||:|:||.:..:...:|::||||:..||.| .......|||.|::||||   .:|||.|.||||
Zfish   136 LKPENLLLASKCKNAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL---RKEAYGKPVDIW 197

  Fly   368 SLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSI 432
            :.||:|:..|.|..||.||......||||.|.:.:..|.|.:|:..||.||||||.::|.:|.:.
Zfish   198 ACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITA 262

  Fly   433 DDVLQSSWL 441
            .:.|:..|:
Zfish   263 QEALKHPWV 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	100/267 (37%)
		S_TKc	174..441	CDD:214567	100/267 (37%)
camk2b1	XP_021331894.1	STKc_CaMKII	11..302	CDD:270988	101/269 (38%)
camk2b1	XP_021331894.1	CaMKII_AD	561..688	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910