DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Camkk1

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001349770.1	Gene:	Camkk1 / 55984	MGIID:	1891766	Length:	505	Species:	Mus musculus

Alignment Length:	360	Identity:	98/360 - (27%)
Similarity:	177/360 - (49%)	Gaps:	55/360 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 IGTNRMRILKNDDVISLSHPTYKAFVFKDLSPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVYD 193
            |.::|:.|...:|.:.|:.                          |.:..::|.||||:|||.|:
Mouse   109 IESHRVAISDTEDCVQLNQ--------------------------YKLQSEIGKGAYGVVRLAYN 147

  Fly   194 TRTCQQFAMKIVKKNML------------SGAR-----PSTNFSDPDRVLNEAKIMKNLSHPCVV 241
            ....:.:|||::.|..|            .|::     |:......:||..|..|:|.|.|..||
Mouse   148 ESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQATQGGPAKQLLPLERVYQEIAILKKLDHVNVV 212

  Fly   242 RMHDIVDKP--DSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDL 304
            ::.:::|.|  |::|:|.:.:|.|.:: .:..:|...|:.::||...:...::|||.:.|.|||:
Mouse   213 KLIEVLDDPAEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276

  Fly   305 KPDNVLLETNDEETLLKVSDFGLS-KFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWS 368
            ||.|:||   .::..:|::|||:| :|...|:.:.:..|||.::|||.:...|:....|.:|:|:
Mouse   277 KPSNLLL---GDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWA 338

  Fly   369 LGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSID 433
            .||.|:..:.|..||.|:|.....::||.....:  |....||:..|.||.:||..:||.|..:.
Mouse   339 TGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVS 401

  Fly   434 DVLQSSWLR---DAPMLQKAKRLMKLDGMEIEEEN 465
            |:....|:.   :.|:..:.:....::..|.|.:|
Mouse   402 DIKLHPWVTKHGEEPLPSEEEHCSVVEVTEEEVKN 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	5/26 (19%)
		STKc_Chk2	167..441	CDD:270986	88/293 (30%)
		S_TKc	174..441	CDD:214567	88/286 (31%)
Camkk1	NP_001349770.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..105
		STKc_CaMKK1	127..410	CDD:271102	89/314 (28%)
		RP domain	167..189		2/21 (10%)
		Autoinhibitory domain. /evidence=ECO:0000250	435..440		1/2 (50%)
		Calmodulin-binding. /evidence=ECO:0000250	438..463
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910