DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and ulk1b

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_002665971.2	Gene:	ulk1b / 558848	ZFINID:	ZDB-GENE-071203-2	Length:	1011	Species:	Danio rerio

Alignment Length:	229	Identity:	81/229 - (35%)
Similarity:	135/229 - (58%)	Gaps:	29/229 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 EEINKTYYVNRK--LGSGAYGLVRLVYDTRTCQ----QFAMKIV-KKNMLSGARPSTNFSDPDRV 225
            |.:.| :..:||  :|.||:.   :|:..|..:    :.|:|.: |||:   |:..|...
Zfish     2 ETVGK-FEFSRKDLIGHGAFA---VVFKGRHREKHEWEVAVKCINKKNL---AKSQTLLG----- 54

  Fly   226 LNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHA 290
             .|.||:|.|.|..:|.:||..:...|||:|:|:..||||.:.:.|...||||..:::..|:..|
Zfish    55 -KEIKILKELKHENIVALHDFQETASSVYLVMEYCNGGDLADYLHSKGTLSEDTIRVFLQQITGA 118

  Fly   291 VKYLHDRGITHRDLKPDNVLL------ETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAP 349
            ::.|..:||.||||||.|:||      :::...|.:|::|||.::::|.:.:..||||:|:|:||
Zfish   119 MRVLQAKGIIHRDLKPQNILLSHPAGRKSHFNNTCIKIADFGFARYLQNNMMAATLCGSPMYMAP 183

  Fly   350 EVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPF 383
            ||:::   :.|..|.|:||:|.::|.||:|..||
Zfish   184 EVIMS---QNYDAKADLWSIGTIVFQCLTGKAPF 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	81/229 (35%)
		S_TKc	174..441	CDD:214567	79/223 (35%)
ulk1b	XP_002665971.2	PKc_like	6..272	CDD:304357	80/225 (36%)
		S_TKc	9..271	CDD:214567	79/221 (36%)
		DUF3543	796..1007	CDD:288883
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910