DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and prkd3

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_685483.4	Gene:	prkd3 / 557337	ZFINID:	ZDB-GENE-130530-880	Length:	891	Species:	Danio rerio

Alignment Length:	352	Identity:	109/352 - (30%)
Similarity:	180/352 - (51%)	Gaps:	49/352 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 KRANCELTNPVYIQDLSRNGTFVNNEK--------IGTNRMRILKNDDVISLSHPTYKAFVFKDL 158
            :||..:...||.:......||.....|        |..:..:|.:|.|:.|:    |:.|.
Zfish   523 ERAIRQALMPVPVTPQPSVGTAAGQSKDHKELSISISVSNSQIQENVDISSI----YQIFA---- 579

  Fly   159 SPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPD 223
                     :|:         ||||.:|:|......:|.:..|:|::.|......:.|
Zfish   580 ---------DEV---------LGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQES------- 619

  Fly   224 RVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNK--LLSEDISKLYFYQ 286
            ::.||..|::||.||.:|.:..:.:.|:.|::|:|.:. ||:|..|:|::  .|.|.|:|....|
Zfish   620 QLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLH-GDMLEMILSSEKSKLPERITKFLVTQ 683

  Fly   287 MCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEV 351
            :..|:::||.:.|.|.||||:||||.:.:....:|:.|||.::.:.:.|..|::.|||.|:||||
Zfish   684 ILVALRHLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 748

  Fly   352 LITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKL 416
            |.:.|   |.:.:|:||:||:::..||||.||:::  .....||:...|.|....||.:|..|..
Zfish   749 LRSKG---YNRSLDMWSVGVIIYVSLSGTFPFNED--EDINDQIQNAAFMYPPTPWKDISAEATD 808

  Fly   417 LINQMLIVDPERRPSIDDVLQSSWLRD 443
            |||.:|.|...:|.|:|..|...||:|
Zfish   809 LINNLLQVKMRKRYSVDKTLSHPWLQD 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	14/61 (23%)
		STKc_Chk2	167..441	CDD:270986	92/275 (33%)
		S_TKc	174..441	CDD:214567	91/268 (34%)
prkd3	XP_685483.4	C1_1	153..202	CDD:278556
		C1	270..319	CDD:237996
		PH_PKD	406..533	CDD:269945	2/9 (22%)
		STKc_PKD	573..832	CDD:270984	95/297 (32%)
		S_TKc	581..833	CDD:214567	92/273 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910