DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and pskh1

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001018546.1	Gene:	pskh1 / 554840	ZFINID:	ZDB-GENE-050119-1	Length:	422	Species:	Danio rerio

Alignment Length:	275	Identity:	92/275 - (33%)
Similarity:	156/275 - (56%)	Gaps:	16/275 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 INKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVL-NEAKIMK 233
            :...|.:...:|.|::..|..|....|.|.:|:|:::          |.:.:...|. :|..:::
Zfish    92 VTAKYDIKALIGRGSFSRVVRVEHRSTRQPYAIKMIE----------TRYREGREVCESELCVLR 146

  Fly   234 NLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRG 298
            .:.|..::::.::.:..:.||||:|...||:|.:|||:....:|..:......:...|||||..|
Zfish   147 RVRHTNIIQLMEVFETAERVYMVMELATGGELFDRIITRGSFTERDATRVLQMVLDGVKYLHTLG 211

  Fly   299 ITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQK--DSVMRTLCGTPLYVAPEVLITGGREAYT 361
            ||||||||:|:|......::.:.::||||:...:|  :.:|:|.||||.|:|||:|:   |:.||
Zfish   212 ITHRDLKPENLLYYHPGADSKIMITDFGLASTRKKGDECLMKTTCGTPEYIAPEILV---RKPYT 273

  Fly   362 KKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDP 426
            ..||:|:|||:.:..||||:||.|:......:||.||::::....|.|||..||..|:::|.|||
Zfish   274 NAVDMWALGVISYILLSGTMPFEDDNRMRLYRQILKGKYSFSGEPWPSVSNLAKDFIDRVLTVDP 338

  Fly   427 ERRPSIDDVLQSSWL 441
            ..|.|....|:..|:
Zfish   339 NERLSAGQALKHPWI 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	91/273 (33%)
		S_TKc	174..441	CDD:214567	91/269 (34%)
pskh1	NP_001018546.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..80
		STKc_PSKH1	94..353	CDD:270989	91/271 (34%)
		S_TKc	96..353	CDD:214567	91/269 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..422
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2971
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940