DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and camk4

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001017607.1	Gene:	camk4 / 550270	ZFINID:	ZDB-GENE-050417-76	Length:	364	Species:	Danio rerio

Alignment Length:	308	Identity:	99/308 - (32%)
Similarity:	163/308 - (52%)	Gaps:	25/308 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 EEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIM 232
            |.:...|.:..:||.||..:|.......|.:.:|:|::||.:           |...|..|..::
Zfish    23 ETLADFYELESELGRGATSVVYRCRQKGTQKHYAVKMLKKTV-----------DKKIVRTEIGVL 76

  Fly   233 KNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDR 297
            ..||||.::::.:|.:.|..:.:|||.:.||:|.:|::.....||..:.....|:..||.|||:.
Zfish    77 LRLSHPNIIKLKEIFETPAEISLVLELVTGGELFDRVVEKGYYSERDAADAVKQVLEAVAYLHEN 141

  Fly   298 GITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGRE-AYT 361
            |:.||||||:|:|..|:..:..||::||||||.|.....|:|:||||.|.|||:|    |. ||.
Zfish   142 GVVHRDLKPENLLYATSAPDAPLKIADFGLSKIVDDQVTMKTVCGTPGYCAPEIL----RGCAYG 202

  Fly   362 KKVDIWSLGVVLFTCLSGTLPFSDEYGTP-AAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVD 425
            .:||:||:||:.:..|.|..||.|:.|.. ..::|....:.:..|.|.:||..||.|:.::::.|
Zfish   203 PEVDMWSVGVITYILLCGFEPFFDDRGDQYMFKRILNCEYEFVSPWWDNVSLNAKDLVKKLIVQD 267

  Fly   426 PERRPSIDDVLQSSWLRDAPMLQKAKRLMKLDGMEIEEENFLEPPTKR 473
            |::|.:....||..|:        ..:.:....|:..::..||...:|
Zfish   268 PKKRLTTQQALQHPWV--------TGKAVNFTHMDTAQKKLLEFNARR 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	94/274 (34%)
		S_TKc	174..441	CDD:214567	93/268 (35%)
camk4	NP_001017607.1	STKc_CaMKIV	25..318	CDD:270987	98/306 (32%)
camk4	NP_001017607.1	Pkinase	29..283	CDD:278497	93/268 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910