DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Bmp2k

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_038948586.1	Gene:	Bmp2k / 498333	RGDID:	1564828	Length:	1122	Species:	Rattus norvegicus

Alignment Length:	302	Identity:	92/302 - (30%)
Similarity:	127/302 - (42%)	Gaps:	60/302 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 VNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLS-HPC 239
            :...|..|.:..|.||   ||  ...::...|.|.....|..|...     .|..|||.|| |..
  Rat    50 LEESLAEGGFSTVFLV---RT--HSGIRCALKRMYVNNTPDLNICK-----REITIMKELSGHKN 104

  Fly   240 VV-----RMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISK----LYFYQMCHAVKYLH 295
            :|     .::.|.|....|.:::|:.|.|.::|::  ||.|....::    ..|...|.||..||
  Rat   105 IVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQM--NKKLQTGFTESEVLQIFCDTCEAVARLH 167

  Fly   296 D--RGITHRDLKPDNVLLETNDEETLLKVSDFG--LSKFV--QKDSV---------MRTLCGTPL 345
            .  ..|.|||||.:|:||  ||....: :.|||  .:||:  |||.|         ..||.
  Rat   168 QCKTPIIHRDLKVENILL--NDAGNYV-LCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLS---- 225

  Fly   346 YVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSV 410
            |.|||::...|.:..|.|.|||:||.:|:......|||.:     :...|..|.|..  |.....
  Rat   226 YRAPEMINLYGGKPITTKADIWALGCLLYKLCFFALPFGE-----SQVAICDGSFTI--PDNSRY 283

  Fly   411 SQRAKLLINQMLIVDPERRPSIDDVLQSSWL------RDAPM 446
            |.....||..||..|||.||   |:.|.|:.      :|.|:
  Rat   284 SHNVHCLIRFMLEPDPEHRP---DIFQVSYFAFKFAKKDCPV 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	90/289 (31%)
		S_TKc	174..441	CDD:214567	90/289 (31%)
Bmp2k	XP_038948586.1	STKc_NAK_like	44..317	CDD:270939	90/295 (31%)
Bmp2k	XP_038948586.1	BMP2K_C	856..1122	CDD:405873
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910